Prevalens, viral load and types diversity of high-risk HPV in patients with infl ammatory and tumor diseases

Зыкова, Т. А.; Неродо, Г. А.; Bogomolova, Olga A.; Дурицкий, М Н; Sustretov, Vyacheslav A.; Nikitina, Vera P.; Menshenina, Anna P.; Шевченко, А. Н.; Khomutenko, Irina A.; Kruze, Polina A.; Filatova, Elena

doi:10.21886/2219-8075-2018-9-1-42-50

Cited by 3 publications

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“…According to the literature, infection of the population in the world with human papillomavirus is from 40 to 80% (Forman et al, 2012;Guan et al, 2012;Bruni et al, 2019). In Western European countries, Russian Federation, the Western countries of the former Soviet Union(Republic of Moldova, Belarus, Ukraine), the Central Asia and Caucasus region, high-risk HPV prevalence ranged to 48.4% (Rogovskaya et al, 2013;Belyaeva et al, 2018;Zykova et al, 2018). Several studies were conducted around the world and in different regions in Russia, but prevalence ratios were always different (Clifford et al, 2005;Sanjosé et al, 2007;Kulmala et al, 2007;Shipitsyna et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

2021

JJBS

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HPV burden is a marker for cervical neoplasms and cancer. Prevalence of HPV infection and HPV genotypes varies amongst different regions. This research was aimed to investigate the age distribution patterns and prevalence of high-risk HPV genotypes among Rostov-on-Don women. Scrapings of epithelial cells obtained from the urogenital tract of 5655 women. Total DNA was extracted by the sorbent method; Real-Time PCR was used to investigate the HPV load and HPV genotyping. HPV was found in 40% of the DNA samples. The HPV infection was most prevalent among women age ≤ 20 years (55,26%) compared to 27,34% of women older than 40 years (p = 0,001). The prevalence of HPV 16/18 types was almost the same in all age groups. More 50% of women with a high HPV load were women at age group 20-30 years old. Among 254 women, 79,13% had single HPV type infection, and 20,86% had multiple HPV infection. The most frequent of high-risk HPV types were 16, 51 and 31 types. The most common variant of genotypes co-exist for multiple HPV infections were genotypes of A7 + A9 phylogenetic groups (30,18 %). Multiple HPV infections were the most prevalent (67,92%) in women at age group 20-30 years old. We concluded the prevalence of HPV infection among younger women was the highest and declined gradually with age among Rostov-on-Don women.

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Section: Discussionmentioning

confidence: 99%

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

2021

JJBS

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Experience of Formation and Implementation of the Regional Program of Immunization of Children's Population of St. Petersburg against Papillomavirus Infection

Симаходский

Ippolitova

2019

Epidemiology and Vaccinal Prevention

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An integrated approach to maintaining reproductive health includes, among other things, primary prevention of cervical cancer and other diseases associated with the human papillomavirus. Girls 11-14 years old vaccination against human papillomavirus is a priority in the fight against HPV-associated diseases. The purpose of the work is to show the methodology of legal support for the formation and implementation of the HPV vaccine prevention program, which is not included in the National Vaccination Calendar, using the example of the system, institutions and services aimed at protecting the reproductive health of children and adolescents in St. Petersburg. Materials and methods. Primary specific prophylaxis of HPV-associated diseases was carried out by certified vaccines: bivalentfor protection against HPV types 16 and 18, and tetravalent-for types 6, 11, 16, 18. Information on vaccination was included in the certificate of preventive vaccinations, form No. 156/у-93 A6. Determining the size of contingents to be vaccinated, taking into account the prevalence of infectious diseases was carried out according to the statistical forms: No. 30 «Information about the medical organization», No. 2 «Information about infectious and parasitic diseases», No. 5 «Information about preventive vaccinations». Results. From 2012 to 2014, 22,548 girls between the ages of 12 and 14 years of age (13% of the subject) were covered by vaccination; from 2015 to 2018, 13,062 girls (7.5% of the subject) were covered. First of all, girls who are on full state support and are at risk (from families with an oncologic history) were vaccinated. From 2015, young woman under 17 years old began to be vaccinated. The planned coverage in 2019 will be 9.2% of the population to be immunized. All vaccinated were patients of children's city polyclinics. Conclusion. The world practice of using vaccination against oncogenic viruses has proven its effectiveness against human papillomavirus infection. Before deciding on the inclusion of vaccines against HPV infection in the National Schedule of Vaccines, the health authorities of the constituent entities of the Russian Federation should actively look for opportunities to form and implement regional vaccination programs. We have shown one of the possible ways. The current favorable conditions for the development of maternal and child health services contribute to the inclusion of vaccination against HPV infection in the immunization schedules of the constituent entities of the Russian Federation.

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Practical Aspects of the Implementation of Screening for the Detection of Malignant Neoplasms of the Cervix during the Medical Examination

Kuleshova,

Domonova,

Romanuk

et al. 2023

Epidemiology and Vaccinal Prevention

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Relevance. The global strategy for cervical cancer elimination includes the active implementation of primary, secondary and tertiary prevention programs. In the Russian Federation, screening for the detection of malignant neoplasms of the cervix is carried out while women contact specialists, as well as an organized procedure during preventive medical examinations of the certain groups of adults. The study of the population structure of circulating human papillоmavirus (HPV) types, and evaluation of the effectiveness of the recommended diagnostic models will improve the direction of the fight against cervical cancer and introduce optimal preventive solutions.Aim. Retrospective analysis of screening effectiveness for the detection of malignant neoplasms of the cervix, carried out during the medical examination in one institution of Moscow.Materials and methods. The study examined 1068 women aged 20 to 81 years (M = 37.82, Me = 35, IQR 27–47 years) from one institution in Moscow over a 5-year follow-up period (2017–2021). The screening was based on the co-testing model: liquid-based cytology with Papanicolaou staining and classification according to the Bethesda system and quantitative Real Time HPV-test with determination of the 14 HPV DNA types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68).Results. The prevalence of the 14 HPV oncogenic types was 14.87% (95% CI: 12.86–17.13%), the most common were 16 (16.98%), 31 (14.47%), 52 (13.21%). The study determined HPV types with the highest relative risk of persistence: 33, 58, 45, and 52 (p < 0.005). The frequency of HPV detection depended on the age of the examined women and was the highest in the age group of 20–29 years (25.58%). The baseline prevalence was 11.82% (95% CI: 9.98–13.94%). 6 HSIL cases associated with HPV types 16 and 31 were identified. 4/6 were in women under 30 years. The probability of intraepithelial lesions of the cervix increased with an increase of HPV DNA concentration: 23.65% and 66.67% with a viral load of 4.0–6.0 lg copies per 105 human cells and > 6.0 lg copies per 105 human cells, respectively.Conclusions. The study confirmed the great value of HPV- test in screening for the detection of malignant neoplasms of the cervix during the medical examination of the certain groups of adult population, taking into account the advantages of typing and quantitative determination of HPV DNA, as well as the need to consider lowering of the recommended age for the start of HPV-testing.

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Prevalens, viral load and types diversity of high-risk HPV in patients with infl ammatory and tumor diseases

Cited by 3 publications

References 0 publications

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

Experience of Formation and Implementation of the Regional Program of Immunization of Children's Population of St. Petersburg against Papillomavirus Infection

Practical Aspects of the Implementation of Screening for the Detection of Malignant Neoplasms of the Cervix during the Medical Examination

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