Experience of Formation and Implementation of the Regional Program of Immunization of Children's Population of St. Petersburg against Papillomavirus Infection
Abstract:An integrated approach to maintaining reproductive health includes, among other things, primary prevention of cervical cancer and other diseases associated with the human papillomavirus. Girls 11-14 years old vaccination against human papillomavirus is a priority in the fight against HPV-associated diseases. The purpose of the work is to show the methodology of legal support for the formation and implementation of the HPV vaccine prevention program, which is not included in the National Vaccination Calendar, u… Show more
“…В настоящее время вакцинация против ВПЧ не включена в национальный календарь профилактических прививок в России, однако внедрена в региональные программы иммунизации и осуществляется в виде пилотных проектов в некоторых субъектах (Московская область, Свердловская область, Санкт-Петербург, Ханты-Мансийский автономный округ, Якутск, Новосибирск, Смоленская область и др.) [32,[38][39][40].…”
Papillomavirus infection (HPV infection) is the leading sexually transmitted infection in prevalence. HPV infection and associated diseases, including cancer, remain one of the global problems of our time. This literature review presents relevant data from foreign studies and domestic works on the state of HPV vaccination in the world, the modern vaccines efficacy for the HPV-associated diseases prevention, current vaccination strategies and their efficacy as well. The aim of the article is to determine the advantages of using gender-neutral vaccination strategy over priority-used vaccination strategy for girls only in the prevention of HPV-associated diseases, including cancer, as well as for eradicating HPV infection in general.
“…В настоящее время вакцинация против ВПЧ не включена в национальный календарь профилактических прививок в России, однако внедрена в региональные программы иммунизации и осуществляется в виде пилотных проектов в некоторых субъектах (Московская область, Свердловская область, Санкт-Петербург, Ханты-Мансийский автономный округ, Якутск, Новосибирск, Смоленская область и др.) [32,[38][39][40].…”
Papillomavirus infection (HPV infection) is the leading sexually transmitted infection in prevalence. HPV infection and associated diseases, including cancer, remain one of the global problems of our time. This literature review presents relevant data from foreign studies and domestic works on the state of HPV vaccination in the world, the modern vaccines efficacy for the HPV-associated diseases prevention, current vaccination strategies and their efficacy as well. The aim of the article is to determine the advantages of using gender-neutral vaccination strategy over priority-used vaccination strategy for girls only in the prevention of HPV-associated diseases, including cancer, as well as for eradicating HPV infection in general.
Background. The age-standardized cervical cancer incidence rate in the Tomsk region in 2021 was consistently higher than the average for the Russian Federation (21.2 / 100,000 versus 13.6 / 100,000 women). Primary prevention of cervical cancer is best achieved by human papillomavirus (HPV) vaccination of girls. Aim. To evaluate HPV vaccine efficacy for the prevention of cervical cancer in the Tomsk region within the framework of implementation of two regional programs: “Prevention of gynecological cancer and rehabilitation of women diagnosed with gynecological cancer in 2008–2010” and “Urgent measures to improve cancer care for the population of the Tomsk region in 2011–2013”. Material and methods. We studied the tolerability and efficacy of HPV vaccination for the prevention of HPV-associated cervical cancer in 439 vaccinated girls aged 9–26 years during a follow-up time of 14-years. Results. The assessment of a 14-year follow-up study of the impact of HPV vaccination on HPV-associated cervical lesions has shown that HPV vaccine is safe and 100 % effective. Conclusion. Further prospects for primary prevention of cervical cancer before the introduction of vaccines against HPV infection in the national immunization schedule indicates the feasibility and real clinical effectiveness of the introduction of regional and regional programs with the development of a mathematical model for optimizing financial costs for primary prevention of cervical cancer, taking into account demographic parameters and socio-economic damage from cervical cancer in the study area.
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