Prevalência da infecção pelo vírus linfotrópico humano de células T - HTLV-1/2 entre puérperas de Cuiabá, Estado de Mato Grosso, 2006

Ydy, Ranuce Ribeiro Aziz; Ferreira, Dalton; Souto, Francisco José Dutra; Fontes, Cor Jésus Fernandes

doi:10.1590/s0037-86822009000100007

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…Another more recent and large study show Brazilian blood donors prevalence of HTLV-1 on the order of one per 1,000 with regional differences probably due to the ethnic origin of the underlying population with indeed a higher prevalence in donors with black skin color (2.14/1,000) versus mixed (1.58/1,000) or white (0.79/1,000; Carneiro-Proietti et al, 2012). Similarly, HTLV-1 prevalence in pregnant women ranges from 0.1 to 0.8% depending on the tested area (Bittencourt et al, 2001; Olbrich Neto and Meira, 2004; Figueiro-Filho et al, 2007; Ydy et al, 2009; Guimaraes de Souza et al, 2012). Interestingly, Salvador de Bahia, a large city of the eastern part of the country, with a majority of inhabitants of African ancestry, is considered as the Brazilian city with the highest global HTLV-1 prevalence (around 1.3% of blood donors, and 1.8% in the general population; Galvao-Castro et al, 1997; Dourado et al, 2003).…”

Section: Htlv-1 Worldwide Distribution and Prevalence Estimates By Gementioning

confidence: 99%

Epidemiological Aspects and World Distribution of HTLV-1 Infection

Gessain¹,

Cassar²

2012

Front. Microbio.

1,102

1,083

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The human T-cell leukemia virus type 1 (HTLV-1), identified as the first human oncogenic retrovirus 30 years ago, is not an ubiquitous virus. HTLV-1 is present throughout the world, with clusters of high endemicity located often nearby areas where the virus is nearly absent. The main HTLV-1 highly endemic regions are the Southwestern part of Japan, sub-Saharan Africa and South America, the Caribbean area, and foci in Middle East and Australo-Melanesia. The origin of this puzzling geographical or rather ethnic repartition is probably linked to a founder effect in some groups with the persistence of a high viral transmission rate. Despite different socio-economic and cultural environments, the HTLV-1 prevalence increases gradually with age, especially among women in all highly endemic areas. The three modes of HTLV-1 transmission are mother to child, sexual transmission, and transmission with contaminated blood products. Twenty years ago, de Thé and Bomford estimated the total number of HTLV-1 carriers to be 10–20 millions people. At that time, large regions had not been investigated, few population-based studies were available and the assays used for HTLV-1 serology were not enough specific. Despite the fact that there is still a lot of data lacking in large areas of the world and that most of the HTLV-1 studies concern only blood donors, pregnant women, or different selected patients or high-risk groups, we shall try based on the most recent data, to revisit the world distribution and the estimates of the number of HTLV-1 infected persons. Our best estimates range from 5–10 millions HTLV-1 infected individuals. However, these results were based on only approximately 1.5 billion of individuals originating from known HTLV-1 endemic areas with reliable available epidemiological data. Correct estimates in other highly populated regions, such as China, India, the Maghreb, and East Africa, is currently not possible, thus, the current number of HTLV-1 carriers is very probably much higher.

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Section: Htlv-1 Worldwide Distribution and Prevalence Estimates By Gementioning

confidence: 99%

Epidemiological Aspects and World Distribution of HTLV-1 Infection

Gessain¹,

Cassar²

2012

Front. Microbio.

1,102

1,083

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“…�a Região Centro�Oeste, a prevalência verificada nessa população variou de 0,2% a 0,7% 4 . Em gestantes, uma prevalência de 0,1% foi observada para o HTLV�1 em Mato Grosso do Sul e Goiás 7 18 , e de 0,2% para HTLV�1�2 em Mato Grosso 25 .…”

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Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

Nascimento

Carneiro

Teles

et al. 2009

Rev. Soc. Bras. Med. Trop.

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Recebido para publicação em 06�08�2009 �ceito em 27�10�2009 � infecção pelo vírus linfotrópico de células T humanas 1 (HTLV�1) está associada com desenvolvimento de doenças graves como a leucemia�linfoma de células T do adulto (�TL) e mielopatia associada ao HTLV�1�paraparesia espástica tropical (H�M�TSP), além de síndromes inflamatórias e complicações infecciosas 24 ABSTRACTThis study aimed to determine the prevalence of HTLV�1 infection among remnant black quilombo communities in Central Brazil. � total of 1,837 individuals were evaluated, among whom nine were HTLV�1�2 seropositive according to ELIS�. �ll of them were positive for HTLV�1 by means of Western blot and�or PCR, thus resulting in a prevalence of 0.5% (95% CI: 0.2�1.0). The HTLV�1 infected individuals ranged in age from 11 to 82 years. The majority of them were females. Regarding risk characteristics, histories of breastfeeding, blood transfusion, multiple sexual partners and sexually transmitted diseases were reported by these individuals. The findings from this study indicate the importance of identifying HTLV�1 infected individuals, as a strategy for infection control and prevention in these remnant quilombos.Key-words: Human T�cell lymphotropic virus 1. Remnant quilombo. Central Brazil. Prevalence.observadas em algumas regiões como o sudoeste do Japão, Melanésia, África equatorial, Caribe e �mérica do Sul 20 . O Brasil é o país com maior número absoluto de indivíduos infectados por HTLV�1, possuindo cerca de dois milhões de portadores 3 . Essa infecção é endêmica em Salvador, Bahia, onde uma prevalência de 1,8% foi encontrada 8 . Segundo �lcântara e cols 1 , a introdução do HTLV�1 nesse estado ocorreu com o tráfico de escravos africanos. Estudo sobre HTLV�1�2, realizado em doadores de sangue nas capitais dos Estados brasileiros e Distrito Federal, obteve soroprevalência de 0,1% a 1%, sendo superior nas Regiões �orte e �ordeste, e inferior no sul do Brasil. �a Região Centro�Oeste, a prevalência verificada nessa população variou de 0,2% a 0,7% 4 . Em gestantes, uma prevalência de 0,1% foi observada para o HTLV�1 em Mato Grosso do Sul e Goiás 7 18 , e de 0,2% para HTLV�1�2 em Mato Grosso 25 . �s comunidades remanescentes de quilombos semi�isoladas no Brasil Central foram fundadas por africanos escravizados, que fugiram para locais de difícil acesso, e instituíram sociedades alternativas conhecidas como quilombos 21 . Considerando a possível origem africana do HTLV�1 e a escassez de estudos

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“…1 ). After this evaluation, 26 articles reporting the prevalence of HTLV were retained for qualitative synthesis 21 , 26 , 31 – 54 . Of these 26 studies evaluated that used confirmatory tests, only 17 reported which types of HTLV were studied and used for quantitative analysis (meta-analysis).…”

Section: Resultsmentioning

confidence: 99%

“…Of these 26 studies evaluated that used confirmatory tests, only 17 reported which types of HTLV were studied and used for quantitative analysis (meta-analysis). Fifteen articles presents data for HTLV-1 and -2 21 , 26 , 33 , 35 , 39 , 40 , 42 , 45 , 46 , 48 – 52 , 54 and two about HTLV-1 43 , 44 . None report data just for HTLV-2.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Vieira

Bidinotto

Dartora

et al. 2021

Sci Rep

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Human T-lymphotropic virus type 1 (HTLV-1) infection may cause serious disease, while pathogenicity of HTLV-2 is less certain. There are no screening or surveillance programs for HTLV-1/-2 infection in Brazil. By performing this systematic review, we aimed to estimate the prevalence of HTLV-1/-2 infections in pregnant women in Brazil. This review included cohort and cross-sectional studies that assessed the presence of either HTLV-1/-2 infection in pregnant women in Brazil. We searched BVS/LILACS, Cochrane Library/CENTRAL, EMBASE, PubMed/MEDLINE, Scopus, Web of Science and gray literature from inception to August 2020. We identified 246 records in total. Twenty-six of those were included in the qualitative synthesis, while 17 of them were included in the meta-analysis. The prevalence of HTLV-1 in Brazilian pregnant women, as diagnosed by a positive screening test and a subsequent positive confirmatory test, was 0.32% (95% CI 0.19–1.54), while of HTLV-2 was 0.04% (95% CI 0.02–0.08). Subgroup analysis by region showed the highest prevalence in the Northeast region (0.60%; 95% CI 0.37–0.97) for HTLV-1 and in the South region (0.16%; 95% CI 0.02–1.10) for HTLV-2. The prevalence of HTLV-1 is much higher than HTLV-2 infection in pregnant Brazilian women with important differences between regions. The prevalence of both HTLV-1/-2 are higher in the Northeast compared to Center-West region.

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Prevalência da infecção pelo vírus linfotrópico humano de células T - HTLV-1/2 entre puérperas de Cuiabá, Estado de Mato Grosso, 2006

Cited by 14 publications

References 19 publications

Epidemiological Aspects and World Distribution of HTLV-1 Infection

Epidemiological Aspects and World Distribution of HTLV-1 Infection

Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

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