Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Vieira, Bruna Angelo; Bidinotto, Augusto Bacelo; Dartora, William Jones; Pedrotti, Luana Giongo; Oliveira, Vanessa Martins de; Wendland, Eliana Márcia

doi:10.1038/s41598-021-94934-7

Cited by 12 publications

(3 citation statements)

References 75 publications

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“…As for the transmission routes within the families, there was no significant difference between the vertical and horizontal transmission routes and the effectiveness of the infection. Regarding the viral genetic sequences obtained from the 22 relatives, today presented the HTLV-1 subtype A genotype (Cosmopolitan Transcontinental), according to other molecular studies conducted in the metropolitan region of the city of Belém [18], Pará [27] and other regions of Brazil [28,29].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Description and Molecular Characterization of Intrafamily Transmission of Human T-Lymphotropic Virus Type 1 in an Endemic Region of Brazil

Pereira¹,

Casseb²,

Nobre³

et al. 2023

Preprint

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Human T-lymphotropic virus type 1 (HTLV-1) is associated with neurological, degenerative, and inflammatory diseases. Brazil has regions with high prevalence rates. The prevalence among relatives of positive people is high, and intrafamily transmission causes the conservation of the infection for different generations. The investigation of epidemiological and molecular factors may clarify the factors associated with the efficacy of intrafamilial transmission of HTLV-1. Objective: To analyze the epidemiological and molecular factors associated with intrafamilial transmission of HTLV-1 in an endemic area of Brazil. Material and Methods: A cross-sectional study investigated 72 relatives from 14 families with more than one infected. Epidemiological data were collected from all family members, and genetic sequencing was performed, phylogenetic analysis of 22 positive relatives. Results: The prevalence of HTLV-1 in families with infected people was 56.94% (41/72). Twelve vertical transmission routes and ten horizontal transmission routes were identified. Phylogenetic analysis demonstrated the absence of polymorphisms between infected mother and child sequences, while sequences of couples presented nucleotide divergence of up to 3%.among themselves. It was also identified in a family with an intrafamilial transmission with the occurrence of two viral strains. Conclusion: Molecular data confirmed intrafamilial transmission. They also indicated little genetic variability between the sequenced samples of family members and those deposited in GenBank used in this study. The absence of polymorphisms was observed in cases of vertical transmission, indicating a tendency to perpetuate identical sequences regardless of the time of acquisition of the infection.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Description and Molecular Characterization of Intrafamily Transmission of Human T-Lymphotropic Virus Type 1 in an Endemic Region of Brazil

Pereira¹,

Casseb²,

Nobre³

et al. 2023

Preprint

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“…The prevalence of HTLV-1/2 in blood donors of Brazil ranges from 0.09 to 0.48% (Catalan-Soares et al, 2005;Pinto et al, 2012;Ribeiro et al, 2018;Pessoni et al, 2019). A systematic review study estimated a prevalence of HTLV-1 in Brazilian pregnant women of 0.32%, while HTLV-2 was 0.04% (Vieira et al, 2021). This virus is transmitted via unprotected sexual intercourse, exposure to the infected blood, or from infected mother to child mainly through breastfeeding (Nunes et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Human T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study

et al. 2022

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Human T-lymphotropic virus (HTLV) infection is endemic in some group populations. Prisoners are at high risk of acquiring HTLV infection mainly due to the environment of closed penal institutions, socioeconomic conditions, and risk behaviors. This study aimed to investigate the prevalence, the occurrence of new cases of HTLV infection after a 1-year follow-up, and circulating subtypes of HTLV-1 among prisoners from twelve closed prisons in Mato Grosso do Sul state, Central Brazil. A total of 1,507 prisoners were randomly enrolled in the cross-sectional study. Out of the 1,507 participants, 1,000 prisoners, susceptible to HTLV infection, were included in the prospective cohort study. In the cross-sectional study, serological evidence of HTLV infection was 0.4% (CI 95%: 0.1-0.7), tested for anti-HTLV antibodies by enzyme-linked immunosorbent assay (ELISA). Three samples were positive for HTLV-1, two samples were positive for HTLV-2, and 1 sample was indeterminate by the Western blot method. The presence of HTLV proviral DNA was detected in all positive samples by amplification of the HTLV tax gene through nested-PCR. Phylogenetic analysis showed that HTLV-1 samples belonged to the Cosmopolitan subtype Transcontinental subgroup. From a cohort of 1,000 individuals, no new case of HTLV infection was detected. Although the prevalence rate of HTLV infection found in this study was similar to that observed in the Brazilian general population, the lack of access to preventive interventions and harm reduction measures all contribute to increasing the risk of HTLV transmission and acquisition among this key and vulnerable population.

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“…HTLV-1 infection is endemic in southwestern Japan, sub-Saharan Africa, South America, and the Caribbean area, with foci in the Middle East and Australo-Melanesia 4 . HTLV-1 infection is frequent in Brazil 5 , in the State of Bahia 6 , particularly in its capital, Salvador city, with an estimated prevalence of 1.8% 7 .…”

Section: Introductionmentioning

confidence: 99%

Work ability and associated factors in people living with human T-cell leukemia virus type 1

Costa¹,

Carvalho²,

Vieira³

et al. 2022

Rev. Soc. Bras. Med. Trop

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Background: Infection with the human T-lymphotropic virus type 1 (HTLV-1) affects an estimated 10-15 million people worldwide. However, knowledge of the impact of HTLV-1 infection on work ability is lacking. This study aimed to measure the frequency and identify factors associated with poor work ability in patients living with HTLV-1. Methods: This cross-sectional study included 207 individuals infected with HTLV-1 who attended the University Hospital in Salvador, Bahia, Brazil. HTLV-1 antibodies were detected in the participants’ blood by enzyme-linked immunosorbent assay (ELISA) and confirmed by western blotting. Participants answered a questionnaire on sociodemographic data, personal habits, clinical data, health-related quality of life, and work ability, evaluated using the work ability index questionnaire. A Poisson regression model with a robust variance estimate was used to identify the factors associated with the prevalence of poor work ability. Results: Patients mean age was 55.2, ranging from 19 to 84 years, 73.0% were females, 100% had monthly family income less than US$ 394, and 33.8% presented HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). No individual was classified as having excellent work ability. Poor work ability prevalence was strongly associated (prevalence ratio; 95% confidence interval [CI]) with sedentarism (1.30; 1.03-1.65), neurological symptoms (1.25; 1.02-1.52), and low physical (0.95; 0.94-0.96) and mental (0.98; 0.97-0.99) component summaries of health-related quality of life. Conclusions: Poor work ability among people living with HTLV-1 is associated with sedentarism, neurologic symptoms, and low health-related quality of life.

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Prevalence of human T-lymphotropic virus type 1 and 2 (HTLV-1/-2) infection in pregnant women in Brazil: a systematic review and meta-analysis

Cited by 12 publications

References 75 publications

Epidemiological Description and Molecular Characterization of Intrafamily Transmission of Human T-Lymphotropic Virus Type 1 in an Endemic Region of Brazil

Epidemiological Description and Molecular Characterization of Intrafamily Transmission of Human T-Lymphotropic Virus Type 1 in an Endemic Region of Brazil

Human T-Lymphotropic Virus-1/2 Infection in Central Brazil Prisons: A Multicenter Study

Work ability and associated factors in people living with human T-cell leukemia virus type 1

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