Prevalence, risk factors and causative organisms of asymptomatic bacteriuria in pregnancy

Patnaik, Manasi; Panigrahi, Kumudini; Das, Banya; Pathi, Basanti; Poddar, Nirmala; Lenka, Priya Ranjan; Pattnaik, Dipti

doi:10.18203/2349-3933.ijam20174281

Cited by 9 publications

(16 citation statements)

References 14 publications

(28 reference statements)

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“…Antibiotic sensitivity testing showed that all the isolates were sensitive to imipenam which is in line with studies by Sujatha [16][17][18][19]25 Among the gram positive isolates, all isolates were 100% sensitive to cefepime, vancomycin, linezolid, imipenam and nitrofurantoin. Studies by Patnaik et al and Bose et al, reported similar results, the increase in antibiotic resistance patterns were may be due to self medication and antibiotic abuse.…”

Section: Discussionsupporting

confidence: 88%

“…In present study, prevalence of ASB is 9.2% which correlates with studies done by Sujatha R et al, [16] . 19,21,17 In present study Escherichia coli was the predominant isolate accounting 56.5%, similar results were reported by Sujatha [16][17][18]21,19,23 A study from Nigeria showed Staphylococcus aureus (72%) as commonest isolate and E. coli being the least (2%). 24 The organisms isolated can be faecal in origin colonizing in the periurethral area.…”

Section: Discussionsupporting

confidence: 88%

“…Studies by Patnaik et al and Bose et al, reported similar results, the increase in antibiotic resistance patterns were may be due to self medication and antibiotic abuse. 19,20 Low costs and easy availability of drugs are other factors contributing to antibiotic resistance.…”

Section: Discussionmentioning

confidence: 99%

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Study of asymptomatic bacteriuria in pregnant women: prevalence, isolates and their antibiotic sensitivity pattern

Sandhya¹,

Mispah

Kelamane

2019

Int J Res Med Sci

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Background: Asymptomatic bacteriuria (ASB) is common in pregnant women due to morphological and physiological changes in the genitor-urinary tract, which untreated may lead to complications like pyelonephritis and may also effect the fetus. The objective of our study was to determine the prevalence of ASB in pregnant women, to identify the organisms responsible and their antibiotic sensitivity pattern.Methods: A clean catch midstream urine was collected from 250 pregnant women in different trimesters attending antenatal OPD in a tertiary care hospital. Isolates and their antibiogram were obtained by conventional methods.Results: Among 250 pregnant women, 23(9.2%) had shown significant bacteriuria, and majority (52.1%) were in 3rd trimester. Escherichia coli (56.5%) was the commonest isolate followed by Klebsiella pneumoniae (17.4%). Most of the isolates showed sensitivity to imipenam, nitrofurantoin and cefepime.Conclusions: Asymptomatic bacteriuria is common during pregnancy which requires a routine examination of urine for culture and sensitivity and the positive cases should be treated with appropriate antibiotics to prevent any further complication.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Study of asymptomatic bacteriuria in pregnant women: prevalence, isolates and their antibiotic sensitivity pattern

Sandhya¹,

Mispah

Kelamane

2019

Int J Res Med Sci

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“…3,4 The present study revealed Escherichia coli as the predominant isolate from urine samples of female patients, which well correlates with many studies. [3][4][5][8][9][10][11][12] The age group wise distribution showed that Escherichia coli isolates were mostly prevalent in adult age group (21-40 years), which also correlates well with the studies conducted by Patnaik M et al, Oli A N et al and Arora G et al 2,4,13 The antibiotic sensitivity pattern of Escherichia coli in this study showed very good sensitivity towards Amikacin, Tigecycline, Meropenem, Fosfomycin, Imipenem, Ertapenem, Piperacillin-tazobactam, Nitrofurantoin, Gentamicin and Tobramycin, whereas showed moderate sensitivity towards Norfloxacin, Ciprofloxacin, Cefepime, Cefazolin, Ceftazidime, Ceftriaxone, Aztreonam and Trimethoprimsulfamethoxazole and showed low sensitivity towards Amoxycillin-clavulinic acid and Ampicillin.…”

Section: Discussionsupporting

confidence: 79%

“…Enterobacter spp. [1][2][3] About 50% of all females experience at least one episode of UTI during their life time. Asymptomatic bacteriuria and urinary tract infections (UTI) have a higher prevalence during pregnancy and in very sexually active females.…”

mentioning

confidence: 99%

Prevalence of multidrug resistance (MDR) and extended spectrum beta-lactamases (ESBLs) among uropathogenic Escherichia coli isolates from female patients in a tertiary care hospital in North India

Das¹,

Mittal²,

Goswami³

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Urinary tract infection (UTI) is a common bacterial infection in women. It is very common during pregnancy and may present as asymptomatic bacteriuria. Escherichia coli is the primary urinary pathogen accounting for 74-90% of uncomplicated urinary tract infection. The aim of the study was to evaluate in-vitro antibiotic susceptibility among urine isolates of Escherichia coli and prevalence of resistance marker like ESBL producer and MDR status.Methods: Mid-stream urine samples of 205 female patients were processed for culture and sensitivity. All the samples were inoculated on culture media and growth showing significant bacteriuria (>105 cfu/ml) were subjected to identification and antibiotic sensitivity testing on Automated system BD Phoenix 100. ESBL status was detected by the system and MDR status was evaluated by standard guidelines.Results: Out of 205 urine samples, 47 samples (22.93%) showed growth of organism. Out of the 47 growth positive samples, 36 (76.60%) samples showed growth of Escherichia coli and out of which 13 (36.11%) were ESBL producer and 23 (63.89%) were ESBL non-producer. Escherichia coli was mostly isolated from younger age group (21-40 years) (61.11%). Antimicrobial susceptibility showed very good sensitivity towards Amikacin, Tigecycline, Carbapenems, Fosfomycin, Piperacillin-tazobactam and Nitrofurantoin. All the isolates of ESBL producer are MDR (100%) and 21.7% of ESBL non-producer are MDR. There is evidence of transfer of resistance genes for non-β-lactam antibiotics along with ESBL resistance marker.Conclusions: Escherichia coli was the predominant uropathogen isolated from female patients and Amikacin, Nitrofurantoin and Fosfomycin can be used as first line drug.

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Frequency of urinary tract infections among pregnant women receiving antenatal care in a tertiary care centre: hospital based cross-sectional study

Sadhvi

Kose

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Urinary tract infections (UTI) are one of the most frequent human bacterial infections, causing substantial morbidity and mortality, with nearly 150 million cases globally per year. The prevalence of UTI (including both asymptomatic bacteriuria and symptomatic infection) in pregnant women in India is reported to range from 3% to 24%. This infection must be adequately diagnosed and efficient treatment must be initiated to prevent maternal and perinatal morbidity.Methods: This was a hospital based cross sectional study. 625 ante natal women recruited during first visit attending antenatal care outpatient department (ANC OPD). We tested their clean catch mid-stream urine sample for routine, microscopic and culture sensitivity test.Results: Out of 625 antenatal women frequency of urinary tract infection was 16.2%. 17% women were symptomatic having one or more symptoms indicative of urinary tract infection and 83% women were asymptomatic. Among symptomatic women, 92.5% women showed culture positivity for one or more bacteria whereas in asymptomatic women, culture was positive in 10.8%. E. coli followed by Klebsiella were the most common isolate identified in both symptomatic and asymptomatic women. On antibiotic sensitivity testing, we found good overall sensitivity of bacteria to commonly used antibiotics such as nitrofurantoin, and norfloxacin but resistant to ampicillin was observed in all women. UTI adversely affects the mother like pyelonephritis, preterm labour and preterm baby and its complications.Conclusions: It is important to identify presence of UTI during pregnancy by doing urine routine and culture sensitivity test in all antenatal women and administration of appropriate antibiotic to affected women so as to reduce the morbidity both in mother and baby.

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Prevalence, risk factors and causative organisms of asymptomatic bacteriuria in pregnancy

Cited by 9 publications

References 14 publications

Study of asymptomatic bacteriuria in pregnant women: prevalence, isolates and their antibiotic sensitivity pattern

Study of asymptomatic bacteriuria in pregnant women: prevalence, isolates and their antibiotic sensitivity pattern

Prevalence of multidrug resistance (MDR) and extended spectrum beta-lactamases (ESBLs) among uropathogenic Escherichia coli isolates from female patients in a tertiary care hospital in North India

Frequency of urinary tract infections among pregnant women receiving antenatal care in a tertiary care centre: hospital based cross-sectional study

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