Study of asymptomatic bacteriuria in pregnant women: prevalence, isolates and their antibiotic sensitivity pattern

Abstract

Background: Asymptomatic bacteriuria (ASB) is common in pregnant women due to morphological and physiological changes in the genitor-urinary tract, which untreated may lead to complications like pyelonephritis and may also effect the fetus. The objective of our study was to determine the prevalence of ASB in pregnant women, to identify the organisms responsible and their antibiotic sensitivity pattern.Methods: A clean catch midstream urine was collected from 250 pregnant women in different trimesters attending antenatal OPD in a tertiary care hospital. Isolates and their antibiogram were obtained by conventional methods.Results: Among 250 pregnant women, 23(9.2%) had shown significant bacteriuria, and majority (52.1%) were in 3rd trimester. Escherichia coli (56.5%) was the commonest isolate followed by Klebsiella pneumoniae (17.4%). Most of the isolates showed sensitivity to imipenam, nitrofurantoin and cefepime.Conclusions: Asymptomatic bacteriuria is common during pregnancy which requires a routine examination of urine for culture and sensitivity and the positive cases should be treated with appropriate antibiotics to prevent any further complication.

Prevalence of asymptomatic Bacteriuria among Pregnant Women in Sirte City (Libya).

“…Regarding the antimicrobial susceptibility pattern of the bacteriuria, we found that the isolated organisms highly susceptible to Imipenem were considered the most effective antibiotics against the most common organisms causing asymptomatic bacteriuria in this study, which were in agreement with other studies in India by Prasanna et al, 2015;and Sandhya et al, 2019, followed by meropenem, amoxyclav, ceftriaxone and ciprofloxacin, however E. coli isolates and other isolates were shown high level of resistant to Penicillin G, erythromycin, clindamycin and cotrimaxazole, respectively. This was found in agreement with other studies by Arredondo-García and Amábile-Cuevas, 2008; Ayoyi et al, 2017;Gohar et al, 2019;Emami et al, 2020. However the antibiotic susceptibility patterns against UTI are shown to be different in different geographical locations.…”

“…Generally, females are more susceptible to UTIs because of the short length of the urethra along with close anal canal. Pregnant women are more commonly affected than normal women due to some anatomical changes occurring during pregnancy (Sandhya et al, 2019). The association of ASB with adverse outcomes of pregnancy is a matter of concern of infections risks.…”

“…However asymptomatic bacteriuria during pregnancy if left untreated may lead to complications like pyelonephritis, which might lead to delivery of premature or low-birthweight infants. (Farshad et al, 2010;Tadesse et al, 2014;Sultan et al, 2015;Sandhya et al, 2019). However Adequate and early diagnosis and treatment reduces the prevalence of these obstetric complications (Schnarr and Smaill, 2008;Jain et al, 2013;kamel et al, 2018).…”

Infección Urinaria en Gestantes: Prevalencia y Factores Asociados en el Eje Cafetero, Colombia, 2018-2019

“…Respecto al tipo de infección urinaria más frecuente en los resultados del presente estudio, la prevalencia de bacteriuria asintomática es del 7,69%, resultado cercano al 8,7% encontrado en Dharan (Nepal) por Thakur y col., 31 ; aunque levemente mayor al 6,1% descrito por Ahmad y col., 32 en un grupo de 392 embarazadas en Srinagar, Kashmir (India); no obstante, en un reciente estudio publicado por Sandhya y col. 33 en el mismo país, se encontró una prevalencia ligeramente mayor (9,2%) en 250 gestantes. Con relación a la cistitis aguda, los hallazgos de este estudio, difieren del 1,3% reportado por Harris y col., 7 en el Centro médico Wilford Hall, San Antonio, Texas (EEUU), en una muestra de 9734 mujeres; así como al 54% descrito por Sanín-Ramírez y col., 34 en Medellín (Colombia), diferencia explicable porque las pacientes tenían síntomas de infección del tracto urinario.…”