Prevalence of some risk factors in children with epilepsy compared to their controls

Cansu, Ali; Serdaroğlu, Ayşe; Yüksel, Deniz; Doğan, Vehbi; Özkan, Seçil; Hırfanoğlu, Tuğba; Şenbil, Nesrin; Gücüyener, Kıvılcım; Soysal, Şebnem; Çamurdan, Aysu Duyan; Gürer, Y.K. Yavuz

doi:10.1016/j.seizure.2007.02.003

Cited by 40 publications

(35 citation statements)

References 45 publications

(71 reference statements)

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“…History of febrile seizures increased five-fold the risk of developing epilepsy, which is consistent with results of previous studies (Daoud et al, 2003;Cansu et al, 2007). The strong association with febrile seizures does not reflect a causal relationship, but may mean that febrile seizures represent an early expression of a low seizure threshold in patients genetically predisposed to epilepsy.…”

Section: Discussionsupporting

confidence: 90%

“…In the Arab world where first-degree consanguineous marriages represent more than 60% of all unions (Etude, 2007), the association to epilepsy has been suggested by some studies (Asadi-Pooya, 2005;Choueiri et al, 2001;Khedr et al, 2013;Benamer and Grosset, 2009;Bourrous et al, 2010) and refuted by others (Daoud et al, 2003;Cansu et al, 2007;Huseyinoglu et al, 2012;Yemadje et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Consanguinity and epilepsy in Oran, Algeria: A case–control study

et al. 2015

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Consanguinity and epilepsy in Oran, Algeria: A case–control study

et al. 2015

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“…History of epilepsy in the family in patients with CP will increase the risk of developing epilepsy. 24 In this study, history of epilepsy in the family was not proven to be a risk factor for epilepsy in spastic CP children. Kulak et al and bruck et al 15 showed different result that may due to information bias about the history of epilepsy in the family in this study.…”

Section: Discussionmentioning

confidence: 59%

Prevalence and risk factors for epilepsy in children with spastic cerebral palsy

Rahmat

Mangunatmadja

Tridjaja

et al. 2016

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Background epilepsy in cerebral palsy (CP) is usually difficult to treat and can lead to poor prognosis due to increased risk for motor and cognitive disorders. The prevalence and risk factors of epilepsy in children with CP vary among studies. Objective To determine the prevalence and risk factors for epilepsy in spastic CP. Methods We performed a retrospective study using medical records of patients with spastic CP at the Departement of Child Health, Cipto Mangunkusumo Hospital from January 2003 until December 2008. Prevalence ratio was calculated by comparing the prevalence of epilepsy in subjects with and without risk factors. We excluded patients with metabolic disorder, genetic syndrome, and onset of CP after 3 years of age. Results Two hundred thirty six out of 238 spastic CP patients were analyzed. The mean age at diagnosis of spastic CP was 28.8 months. male to female ratio was 1.4:1. The prevalence of epilepsy in spastic CP was 39%. The risk factors for epilepsy in spastic CP were central nervous system infection, the ocurrence of seizure in the first year of life, and abnormality of eeG. Conclusions The prevalence of epilepsy in spastic CP is 39%. The risk factors for epilepsy in spastic CP are post central nervous system infection, and ocurrence of seizure in the first year of life.

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“…Results of several other studies of the familial occurrence of epilepsy have reported various results mainly related to the method of case ascertainment. A case-control study from our country revealed an increase in the history of epilepsy in first-, second- and third-degree relatives (6.42-, 3.09-, and 2.66-fold) [16]. In a population-based study in Pakistan, Aziz et al [9] reported that 32% of the epileptic patients had relatives with epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Epilepsies in Family Members of Patients with Different Epileptic Syndromes

Sözmen

Baybaş²,

Dırıcan³

et al. 2010

Eur Neurol

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Aim: To determine the frequency of epilepsies in the family members of epileptic patients. Methods: The records of 4,851 patients with epilepsy were reviewed. The frequency and patterns of different epilepsies and epileptic syndromes in the patients, number of affected relatives and consanguinity were studied. Results: A total of 1,753 patients were excluded due to various reasons. Of the remaining patients, 296 (9.5% of 3,098) had first- or second-degree relatives affected with seizures. The incidence of family history in the localization-related cryptogenic epilepsies group was significantly higher than all other groups (246 patients). Juvenile myoclonic epilepsy was the most frequent epileptic syndrome (34 patients). Consanguinity was detected in 56 patients, and 33 (58.9%) of these subjects were in the localization-related cryptogenic epilepsies group. Of all subjects, 59 (19.9%) had more than 1 epileptic family member. The ratio of affected first- to second-degree relatives was 202/94. Conclusions: A considerable number of the relatives of epileptic patients have seizures. The risk of relatives being affected depends on their relationship with the proband. Genetic factors may play an almost equal role in the predisposition of relatives to epilepsy in families of probands with cryptogenic and idiopathic epileptic syndromes.

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Prevalence of some risk factors in children with epilepsy compared to their controls

Abstract: The most important risk factors for epilepsy in this study were neurological impairment, history of atypical febrile seizures, severe head injury and a low apgar score. Other important risk factors were moderate head trauma and a history of epilepsy in the family.

Cited by 40 publications

References 45 publications

Consanguinity and epilepsy in Oran, Algeria: A case–control study

Consanguinity and epilepsy in Oran, Algeria: A case–control study

Prevalence and risk factors for epilepsy in children with spastic cerebral palsy

Frequency of Epilepsies in Family Members of Patients with Different Epileptic Syndromes

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