Consanguinity and epilepsy in Oran, Algeria: A case–control study

Chentouf, Amina; Talhi, Randa; Dahdouh, Aïcha; Benbihi, Latifa; Benilha, Soumia; Oubaiche, Mohand Laid; Chaouch, Malika

doi:10.1016/j.eplepsyres.2014.12.014

Cited by 22 publications

(14 citation statements)

References 57 publications

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“…Consanguineous marriage is a traditional issue, especially in eastern part of Turkey (12). Numerous studies has suggested that consanguinity is a frequent risk factor for seizure disorders in developing countries (13,14). Our study was conducted in a hospital which is located in a north-west township established with massive rural-to-urban migration from eastern regions.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Demographic Profile of Patients with Active Epilepsy: Experience From a Tertiary Care Hospital in Turkey

Basaran¹,

Öğün²

2019

Kocaeli Med J

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Section: Discussionmentioning

confidence: 99%

Clinical and Demographic Profile of Patients with Active Epilepsy: Experience From a Tertiary Care Hospital in Turkey

Basaran¹,

Öğün²

2019

Kocaeli Med J

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“…Otros estudios han encontrado un riesgo de 2 a 4,6 % para los individuos que tiene un familiar epiléptico en primer grado (8,18).…”

Section: Discussionunclassified

“…Este patrón implica una forma compleja de herencia, cuyo riesgo es impartido por los efectos aditivos de múltiples genes y factores ambientales (13,18).…”

Section: Discussionunclassified

“…Para las crisis focales, el ácido valpróico se usó más que la carbamazepina y si de crisis generalizada se trata, fue el preferido con una diferencia más significativa. Chentouf et al (18) reportan que el agente antiepiléptico más usado es el ácido valpróico (31,7 %), similar en el presente estudio.…”

Section: Discussionunclassified

“…Para el departamento de Caldas, Díaz et al (9) hallan prevalencia de 24 por 1 000 habitantes; lo propio hace Alcázar et al (10) (14) encuentran que la encefalopatía hipóxico-isquémica o posasfíctica y los estados hipertensivos en el embarazo tienen relación con la presencia de epilepsia en los niños (15). Para Knupp et al (16) y Ortiz (17), los antecedentes familiares para epilepsia son también factores de riesgo asociados (18). Las neuroinfecciones (19), los traumatismos craneoencefálicos y anomalías del sistema nervioso central (9,20), se relacionan con la presencia de convulsiones provocadas (no epilépticas).…”

Section: Introductionunclassified

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Caracterización de la población con epilepsia atendida en un hospital infantil en Manizales 2013-2014

Castaño-Castrillón

Campos-Quimbayo

Duque-Jiménez

et al. 2016

CES Med

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Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes

et al. 2018

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Genetic generalized epilepsies (GGE) (childhood absence epilepsy (CAE), juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures (GTCS)) are mainly determined by genetic factors. Since few mutations were identified in rare families with autosomal dominant GGE, a polygenic inheritance was suspected in most patients. Recent studies on large American or European cohorts of sporadic cases showed that susceptibility genes were numerous although their variants were rare, making their identification difficult. Here, we reported clinical and genetic characteristics of 30 Tunisian GGE families, including 71 GGE patients. The phenotype was close to that in sporadic cases. Nineteen pedigrees had a homogeneous type of GGE (JME-CAE-CGTS), and 11 combined these epileptic syndromes. Rare non-synonymous variants were selected in probands using a targeted panel of 30 candidate genes and their segregation was determined in families. Molecular studies incriminated different genes, mainly CACNA1H and MAST4. The segregation of at least two variants in different genes in some pedigrees was compatible with the hypothesis of an oligogenic inheritance, which was in accordance with the relatively low frequency of consanguineous probands. Since at least 2 susceptibility genes were likely shared by different populations, genetic factors involved in the majority of Tunisian GGE families remain to be discovered. Their identification should be easier in families with a homogeneous type of GGE, in which an intra-familial genetic homogeneity could be suspected.

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Consanguinity and epilepsy in Oran, Algeria: A case–control study

Cited by 22 publications

References 57 publications

Clinical and Demographic Profile of Patients with Active Epilepsy: Experience From a Tertiary Care Hospital in Turkey

Clinical and Demographic Profile of Patients with Active Epilepsy: Experience From a Tertiary Care Hospital in Turkey

Caracterización de la población con epilepsia atendida en un hospital infantil en Manizales 2013-2014

Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes

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