Prevalence of &lt;i&gt;Tyrophagus putrescentiae&lt;/i&gt; Hypersensitivity in Subjects over 70 Years of Age in a Veterans’ Nursing Home in Taiwan

Liao, En-Chih; Ho, Chau-Mei; Tsai, Jaw‐Ji

doi:10.1159/000288290

Cited by 13 publications

(13 citation statements)

References 35 publications

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“…Fifty-two percent of adult individuals over the age of 50 are sensitive to Tp, which is much more prevelent than Dp sensitization in the same age group (22%). Similar findings have been reported in Korea [29]. …”

Section: Different Age Groups Of Subjects Sensitized By Different Spesupporting

confidence: 91%

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House dust mite allergy: environment evaluation and disease prevention

Liao

Tsai

2014

Asia Pacific Allergy

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There are two groups of dust mites, house dust mites (HDMs) and storage mites (SMs), that have been identified in the household environment. Both could induce airway inflammation through activation of innate and adaptive immunity and lead to asthma. In order to monitor environmental dust mite infestation, different methods can be used to detect their presence, such as the use of floating methods, monoclonal antibodies, and nanostructured biosensor. SM could be identified in the storage room, mainly in contaminated food such as mushrooms and corn starch. In HDM-sensitive subjects and mice that were challenged with HDM or SM after sensitization, these mites could up-regulate IgE levels, T helper 2 associated cytokine production and airway hypersensitivity. Different age groups of subjects were sensitized by different species of mites. More subjects above 70 years were sensitized by SM and more subjects below the age of 40 years were sensitized to HDM. Different allergenic components of dust mite extracts, such as Der p 1, Der p 2, could activate innate immunity through activating pattern recognition receptor (PRR) and then lead to allergic inflammation. The best modality to treat HDM allergy is immunomodulation through Treg cells and IgA production. In the recent years, many studies indicated probiotics could increase IgA secretion and the number of Treg cells. However, some studies conducted in adults have contradictory effects in reducing allergic symptoms. Therefore, probiotics confer inconclusive benefits on the allergic symptoms.

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Section: Different Age Groups Of Subjects Sensitized By Different Spesupporting

confidence: 91%

“…The results showed that, among the 63 elderly subjects, 50 (79.3%) had COPD. Among the 50 subjects with COPD, 38.0% (19/50) were Tp-sensitive subjects and 14.0% (7/50) were Dp-sensitive subjects [29]. All of the Dp-sensitive subjects were also Tp-sensitive.…”

Section: Different Age Groups Of Subjects Sensitized By Different Spementioning

confidence: 99%

House dust mite allergy: environment evaluation and disease prevention

Liao

Tsai

2014

Asia Pacific Allergy

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“…In our previous study, we had investigated the relationship between T. putrescentiae and D. pteronyssinus allergy in allergic rhinitis individuals by using skin prick tests, basophil histamine release assays in vitro and specific IgE measurements [ 18 ]. The reactivity between T. putrescentiae and D. pteronyssinus was investigated and results showed that the major cross-reacting allergen was Group 2 allergens and species-specific allergen was Group 3 allergens [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…The IgE responsiveness against mite crude extracts in sera of allergic patients was determined by an enzyme-linked immunosorbent assay (ELISA) as previously described [ 27 ]. Briefly, the mite crude extracts used were coated separately onto wells of polyvinyl microtiter plates (Costar, Cambridge, MA, USA) by the addition of 100 μL of a 5-μg/mL solution of crude extract in coating buffer 0.1-mol/L NaHCO 3 , pH 8.4 for 4 h at RT.…”

Section: Methodsmentioning

confidence: 99%

Identification the Cross-Reactive or Species-Specific Allergens of Tyrophagus putrescentiae and Development Molecular Diagnostic Kits for Allergic Diseases

Tsai

Lin

et al. 2020

Diagnostics

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Mite allergens are considerable factors in the genesis of allergic diseases. The storage mite Tyrophagus putrescentiae (Tp) appears in contaminated foods and household surroundings. The current diagnostic tools for Tp allergy are mostly based on crude extracts and still contain shortcomings. This study aimed to investigate the immunoglobulin E (IgE)- responsiveness profiles of Tp-allergic patients and develop a molecular diagnostic method using recombinant allergens. Allergenic components were characterized as cross-reacting or species-specific allergens, in which the effective combinations of recombinant allergens were developed and analyzed in terms of the prediction accuracy for clinical diagnosis. Seven recombinant allergens were cloned and generated to detect the IgE responsiveness of the Tp allergy. A survey on the prevalence of mite allergy showed there were higher sensitizations with IgE responsiveness to house dust mites (HDM) (78.9–80.9%) than to storage mites Tp (35.6%). Prevalence of sensitization to Tp was higher in elderly subjects. The principal IgE-binding components of Tp were Tyr p 1, Tyr p 2 and Tyr p 3. Prediction accuracy for Tp allergy by IgE-responsiveness combination D (Tyr p 1, Tyr p 2 & Tyr p 3) was with high precision (100%). Avoiding the cross-reactivity of Dermatophagoides pteronyssinus, the prediction accuracy of IgE-responsiveness combination H+ (Tyr p 1, Tyr p 2, Tyr p 3, Tyr p 7, Tyr p 8, Tyr p 10 & Tyr p 20) was suitable for Tp-specific diagnosis. Panels of Tp allergens were generated and developed a diagnostic kit able beneficial to identify IgE-mediated Tp hypersensitivity.

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“…Infestation levels of both house dust mites (Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae) and storage mites (Blomia tropicalis and Tyrophagus putrescentiae (Tp)) have been shown to be high in houses around the world (4-6). These mites have been reported to be clinically important (7)(8)(9), and it has been demonstrated that both mites can concurrently sensitize patients (10,11).…”

Section: Introductionmentioning

confidence: 99%