Prevalence of <i>Helicobacter pylori</i> in Patients with Nasal Polyps: A Preliminary Report

Koç, Can; Arıkan, Osman Kürşat; Atasoy, Pınar; Aksoy, Altan

doi:10.1097/01.mlg.0000147924.96980.34

Cited by 43 publications

(35 citation statements)

References 22 publications

(45 reference statements)

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“…Koc et al [16] demonstrated H. pylori in 20 % of cases based on IHC but the results were not the same with ELISA. Serology has a limitation of not discriminating old and new infection; also, it cannot distinguish the infection present at different sites.…”

Section: Resultsmentioning

confidence: 93%

“…It has also been identified in human dental plaques, saliva, in oral lesions and ulcers, and in adenotonsillar tissue [10,11]. Later studies have detected H. pylori in nasal mucosa of chronic rhinosinusitis [12][13][14][15] and nasal polyps [16][17][18][19][20][21][22][23][24] with variable results, which can be attributed to different sample size and detecting methods.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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To detect the presence of Helicobacter pylori in nasal polyps. A case-control study was conducted enrolling 35 patients with nasal polyps (cases) and patients undergoing septoplasty (controls). Fresh tissue samples were used for urea broth test and imprint cytology, while formalin fixed tissue sections were used for morphology, special stains and immunohistochemistry for H. pylori. Fresh stool samples from both groups were tested to correlate the gastrointestinal status. H. pylori was detected in 40.0 % (14/35) of cases and 8.5 % of controls (3/35) (p = 0.004) by immunohistochemistry. Amongst cases, eight were positive with urea broth test, six with imprint cytology (Giemsa stain), three with H & E, and nine with modified McMullen's stain. Hyperplasia of the lining epithelium and lymphoid aggregates were significantly noticed in nasal polyps positive for H. pylori. Stool antigen test was positive in subjects who were positive for H. pylori in the nasal mucosa. There appears to be an association between H. pylori and nasal polyps. Immunohistochemistry is more sensitive and specific method to detect H. pylori.H. pylori induced inflammatory tissue reaction pattern indicates a possible causal association. Further studies are needed to prove the causal relationship between H. pylori and nasal polyps.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Detection of Helicobacter pylori in Nasal Polyps

Bansal

Sharma

Agarwal

et al. 2016

Head and Neck Pathol

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“…GORD was assessed in three studies (26)(27)(28), which found that 87.5% (14/16) of subjects with intranasal H. pylori had GORD.…”

Section: Pathogenic Factorsmentioning

confidence: 99%

Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis

Leason¹,

Barham²,

Oakley³

et al. 2017

Rhin

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Introduction: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS).The association of GORD with CRS is systematically assessed from the medical literature.Methodology: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included. Studies without a control group, case reports and review articles were excluded. Results:The search returned 958 records, with an additional 10 found from bibliographic lists; this produced 32 studies. The included studies (n=32) consisted of studies reporting pathogenic factors (n=20), epidemiological association (n=8), prognostic interactions (n=3), and a combination of these outcomes (n=1). Potential pathogenic roles for GORD in CRS were supported; CRS subjects had greater prevalence of intranasal Helicobacter pylori and acid reflux than subjects without CRS. CRS is more prevalent in GORD sufferers than those without GORD. Evidence is conflicting for GORD as a factor in CRS treatment failure. Conclusion:The results support a significant association of GORD with CRS. Physicians should be cognizant of the potential for acid and non-acid reflux as a driving factor in CRS.

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“…This bacterium is a Gram negative, curved, bacillus and a major etiological agent of gastritis and peptic ulcer disease [8]. It can also cause extragastrointestinal diseases including coronary artery diseases, acne roseacea, glaucoma, head and neck carcinomas, and chronic rhinosinusitis [9]. For example, in the study of Koc et al [9] H. pylori was found in 20% of the cases with nasal polyposis and none (0%) in the control group based on immunohistochemistry (IHC).…”

Section: Introductionmentioning

confidence: 99%

“…It can also cause extragastrointestinal diseases including coronary artery diseases, acne roseacea, glaucoma, head and neck carcinomas, and chronic rhinosinusitis [9]. For example, in the study of Koc et al [9] H. pylori was found in 20% of the cases with nasal polyposis and none (0%) in the control group based on immunohistochemistry (IHC). Since there are contradictions among studies about the relationship between H. pylori and nasal polyposis, particularly in the previous studies the researchers did not use highly sensitive and gold standard methods for H. pylori detection (such as PCR and culture), the negative and positive results could be criticized.…”

Section: Introductionmentioning

confidence: 99%

Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture

Nemati

Mojtahedi

Naghavi

et al. 2011

Eur Arch Otorhinolaryngol

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The aim of this study was to identify the presence of Helicobacter pylori in nasal polyp specimens of patients with nasal polyposis. A cross-sectional study with control group was performed on fresh tissue samples from 25 patients with nasal polyps, and 25 persons with concha bollusa (control group). Patients with symptoms of gastroesophageal reflux (GERD) were not enrolled. Samples were studied by three methods: polymerase chain reaction (PCR), culture, and urease test. All the diagnostic tests were negative for H. pylori in both the case and control groups. In conclusion, there was no association between H. pylori and nasal polyposis in patients without GERD signs or symptoms in our study, and further studies are needed to assess other potential factors that may influence the development of nasal polyposis.

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Prevalence of Helicobacter pylori in Patients with Nasal Polyps: A Preliminary Report

Abstract: This study indicates that H. pylori was found in increased prevalence in the nasal polyps. However, further controlled epidemiologic studies would be necessary to confirm our results and clarify the potential underlying pathogenetic mechanisms.

Cited by 43 publications

References 22 publications

Detection of Helicobacter pylori in Nasal Polyps

Detection of Helicobacter pylori in Nasal Polyps

Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis

Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture

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