Detection of Helicobacter pylori in Nasal Polyps

Bansal, Divya; Sharma, Sonal; Agarwal, Sarla; Saha, Rumpa; Gupta, Neelima

doi:10.1007/s12105-016-0699-4

Cited by 11 publications

(27 citation statements)

References 31 publications

(40 reference statements)

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“…H&E could not pick up any cases of H. pylori in nasal polyps, but a typical hyperplasia of the lining epithelium and lymphoid aggregates as a significant change in the usual morphology of nasal polyps of truly positive cases 3 (8.57%) as the non exposed part of the polyp was sent for H & E stain, were seen ( Figure 3) similar finding was seen by Bansal et al 18 But different and larger studies are required to confirm these findings. However, in all above studies there was a difference in detection rate by urease, Giemsa, H&E and culture method.…”

Section: Resultssupporting

confidence: 78%

“…positivity which is lower than our observations. [17][18][19] Giemsa stain, in the study conducted by Al-Abbasi et al reported higher rates of 42% were positive when compared to our study. 20 Both urease test and Giemsa stain is easy to perform, cheap and has sensitivity 90-92%.…”

Section: Resultscontrasting

confidence: 52%

“…Many studies conducted on H. pylori and nasal polyposis have used non specific stain and very little information is available on specific stain and correlation with culture studies. [17][18][19][20] Hence the present study has taken to correlate with specific and non specific tests and stain in detection of H. pylori in nasal polyp which help in further research and modification of treatment.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Helicobacter pylori in nasal polyposis

Nandyal¹,

Naik²,

Sahana³

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Background: A significant number of patients with gastro esophageal reflux disease (GERD) disease are actually infected with Helicobacter pylori, transmission of the bacteria from stomach to nose may occur. Few studies have revealed the presence of Helicobacter pylori in normal nasal mucosa, in patients with chronic rhino sinusitis and in nasal polyps but the results have been conflicting and further studies are required for its establishment. The aims and objectives of the study were to study the presence of Helicobacter Pylori in nasal polyp specimen by using non specific tests- rapid urease test, Giemsa stain and H&E stain, specific tests-immunohistochemistry and culture.Methods: 35 patients with nasal polyp were underwent endoscopic nasal polypectomy. Specimens were analyzed for presence of Helicobacter pylori by urease test, Giemsa stain, Hemotoxylin and Eosin stain, Immunohistochemistry and culture. Results: Out of 35 patients 10 patients had gastro esophageal reflux disease (GERD), in which 06 patients showed positive for urease test and Giemsa stain and 3 patients picked up by immunohistochemistry test and growth in culture media. Of which Helicobacter pylori positive cases by H&E stain showed typical hyperplastic epithelium and lymphoid aggregation.Conclusions: There exists an association between H. pylori and nasal polyps and GERD. Non-specific urease test and modified Giemsa stain were positive in considerable number of cases, but the statistical significance could not be established. Immunohistochemistry and culture can be regarded as the procedure of choice in truly positive cases infected with H. pylori along with hyperplastic epithelium in H & E stain, all with co-relative finding but require larger study to establish their association which will help in further research and treatment.

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Section: Resultssupporting

confidence: 78%

Section: Resultscontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Helicobacter pylori in nasal polyposis

Nandyal¹,

Naik²,

Sahana³

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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show abstract

“…The study group included 8 patients with asthma, 6 with allergic rhinitis, and 2 with intolerance to nonsteroidal anti-inflamma- (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) . Admittedly, this prevalence could indeed be greater if the bacterium in the nose would follow a similar mosaic pattern of mucosal infection as in the stomach, with patches of diseased mucosa alternating with non-infected normal mucosa, in which case it would require repeated and extensive sampling to allow for a positive H. pylori result (five different sites, according to some) (20) .…”

Section: Resultsmentioning

confidence: 99%

“…Helicobacter pylori DNA has been detected in a number of extragastric locations, such as the oral cavity, tonsils and adenoids (1,2) , and even the middle ear and paranasal sinuses (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) . However, the significance of the microorganism's presence at these aero-digestive and respiratory sites is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori in both the sinuses and the stomach

Dinis¹,

Matos²,

Sardinha³

et al. 2018

RHINOL

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Background: The role played by Helicobacter pylori in the sinuses, and its association with the same organism's gastric infection, are still unclear. Methods: In order to compare H.pylori colonization patterns in the nose and stomach we conducted a cohort analysis of 14 patients, eligible for sinus surgery due to chronic medically refractory rhinosinusitis, who were tested for simultaneous presence of H. pylori, by histology, culture and polymerase chain reaction, in pathologic sinus tissue collected during surgery and in gastric mucosa obtained through gastroduodenal endoscopy. Results: H. pylori DNA was found in the sinus mucosa of 15.4% of patients with chronic rhinosinusitis, and all of them showed concurrent H. pylori stomach infection. Sinus colonization was not found without simultaneous gastric colonization, although most patients with gastric infection did not have the bacterial DNA in their sinuses. H. pylori's presence in the nose was not associated with local inflammatory status, and no cultures could be obtained from any of the sinus tissue samples, including those positive for H. pylori DNA. Conclusions: Only H. pylori DNA, and not the culturable active form of the microorganism, could be found in the sinus mucosa of some patients with H. pylori gastric infection. We could not find evidence, however, that the bacterium's presence in the nose contributes to local mucosal inflammation.

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Association of Helicobacter pylori infection with olfactory function using smell identification screening test

Bezgin

Çakabay

İrak

et al. 2017

Eur Arch Otorhinolaryngol

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The aim of the present study is to investigate the role of Helicobacter pylori in olfactory function. Thirty-six patients (mean age 38.5) aged between 18 and 55 years who were diagnosed with H. pylori by gastric biopsies and age- and sex-matched 30 healthy adults (mean age 33.6) were included in the study. All participants underwent a detailed ear-nose-throat examination including endoscopic examination of the nasal cavity and laryngeal area, and olfactory tests were performed using the Sniffin' Sticks, a 12-item screening test (Sniffin'Sticks; Burghart, Wedel, Germany) and odor scores were recorded. The mean odor score was 7.9 ± 1.7 (range 2-10) in the patient group and 10.3 ± 1.4 (range 6-12) in the control group. There were significant lower scores in the patient group compared to the control group (p < 0.05). In conclusion, it is apparent that there is an association of H. pylori infection with olfactory dysfunction. H. pylori infection should be considered as possible etiological factors in patients with olfactory dysfunction.

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Detection of Helicobacter pylori in Nasal Polyps

Cited by 11 publications

References 31 publications

Association of Helicobacter pylori in nasal polyposis

Association of Helicobacter pylori in nasal polyposis

Helicobacter pylori in both the sinuses and the stomach

Association of Helicobacter pylori infection with olfactory function using smell identification screening test

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