Prevalence and clinical profile of insulin resistance in young women of poly cystic ovary syndrome: A study from Pakistan

Abstract

Objective: The aim was to estimate the prevalence of Insulin Resistance (IR) in Poly Cystic Ovary Syndrome (PCOS) and analyze its clinical parameters. Methodology: This observational study was conducted at Dow University Hospital during June 2011 till May 2012. Patients of PCOS were selected, an anthropometric measurement, examination and fasting blood test for sugar (FBS) and insulin was performed. Data was collected on pre designed questionnaire, was analyzed by SPSS version 16. Results: Forty-six cases of PCOS were included in the study. Prevalence of IR was 34.78%. Mean age of patients was 23.72 ± 4.37 years. Waist Hip Ratio (WHR) was raised in 42 (91.30%), acanthosis was found in 26(56.50%), impaired FBS was seen in 9 (19.6%) and raised fasting insulin in 16 (34.8%) patients. There was significant association between acanthosis and WHR (0.044) and between acanthosis and FBS (0.008). Correlation studies between parameters showed a significant correlation between Waist & Hips (0.93), similarly Waist & WHR showed positive correlation (0.59), at p< 0.01. Significant positive correlation was also found between waist and FBS (0.32) and FBS & WHR (0.378). Conclusion: Acanthosis nigrican, raised WHR and FBS are significant parameters for insulin resistance in cases of Poly Cystic Ovary Syndrome (PCOS).

Clinical Presentation and Frequency of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: An Experience From a Tertiary Care Hospital in Pakistan

“…Several other case control studies reported statistically significant high fasting insulin levels and HOMA-IR in women with PCOS [ 11 , 22 , 24 ]. However, this observation was contradictory to a study that showed IR in only one third participants [ 29 ]. The variation in genetic and environmental factors may be the reason behind the difference in severity of IR in different studied population [ 26 ].…”

Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic‐hyperinsulinemic clamps

“…3 The mechanism is complex and remains unclear. [5][6][7] It is usually accepted that obese women with PCOS have IR. 4 IR occurs in 40%-70% of women with PCOS.…”

“…4 IR occurs in 40%-70% of women with PCOS. [5][6][7] It is usually accepted that obese women with PCOS have IR. Obesity may increase PCOS prevalence and exacerbate IR in women with PCOS.…”

Level of Chemerin and Anti-Müllerian Hormone in Egyptian Obese Women with Polycystic Ovarian Syndrome

“…Insulin resistance and concomitant hyperinsulinemia are frequently found in obese PCOS women and occurs in around 50% to 80% of women with PCOS. The cause of insulin resistance is likewise complex and multifactorial with genetic and environmental contributors (6) .Women with PCOS have defects in both peripheral, which reflects primarily skeletal muscle, and hepatic insulin action, as well as pancreatic β-cell dysfunction (7) .Chemerin is a newly discovered adipokine that regulates adipocyte development and metabolic function as well as immune function (8) .Chemerin may be one of the most important links between adiposity and insulin resistance, and thus a good clinical marker for metabolic dysfunction (9) .Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that belongs to the transforming growth factor-beta family. It is involved in the regression of the Mullerian ducts during male fetal development (10) .…”