Clinical Presentation and Frequency of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: An Experience From a Tertiary Care Hospital in Pakistan

Anjum, Sarwat; Askari, Saima; Riaz, Musarrat; Basit, Abdul

doi:10.7759/cureus.11860

Cited by 11 publications

(13 citation statements)

References 26 publications

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“…An Indian study represents similar findings, indicating that the metabolic dysfunctions are more distinct in obese females with PCOs than those without PCOs 21 . Furthermore, atherogenic dyslipidemia is also more common among obese females with PCOs than females without PCOs 22 . Obese females with PCOs showed a substantially high score on HOMA-IR as compared to the obese females without PCOs.…”

Section: Discussionmentioning

confidence: 99%

Insulin Resistance in young obese females with and without Polycystic Ovary Syndrome.

Shehzad

Sattar

Ishaq

2022

Int. j. endorsing health sci. res.

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Background: The present study intends to determine the comparative insulin resistance (IR) among young obese females with and without polycystic ovary syndrome (PCOs) using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Methodology: During this comparative cross-sectional study, a total of 300 young obese females were evaluated for the presence of PCOS and insulin resistance. Based on the PCOs diagnosis, 250 obese PCOs females were included in group 1, and group 2 comprised 50 obese non-PCOs females. With the demographic details, patients' diabetic and lipid profiles were also evaluated, and the difference in the inference between the groups was drawn using SPSS version 22.0. Results: It is to note that more than 90% of the young obese PCOs females were diagnosed with type 2 diabetes mellitus (T2DM) while none of the obese non-PCOs females had diabetes. Furthermore, the HOMA-IR score was significantly high among young obese females diagnosed with PCOs (16.30 ± 1.62) as compared to those without PCOs (3.47 ± 0.37) (p<0.01). Conclusion: It is concluded from the study results that young obese females with PCOS are more prone to develop insulin resistance than those without PCOs.

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Section: Discussionmentioning

confidence: 99%

Insulin Resistance in young obese females with and without Polycystic Ovary Syndrome.

Shehzad

Sattar

Ishaq

2022

Int. j. endorsing health sci. res.

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“…During the last decade, the prevalence of MS has increased in the general population -and this increase has been steeper in women, particularly in young ones. 2,5,9 A cross sectional study done at the Gynecologic Endocrinology Unit in Bangkok enrolled 250 PCOS Thai women who were diagnosed using Revised Rotterdam 2003 criteria and found the prevalence of MS by the definitions of NCEP ATP III to be 18.0%. 10 Several international studies showed variable frequencies.…”

Section: Discussionmentioning

confidence: 99%

“…3 Overall, it is believed that both PCOS and metabolic syndromes are common in reproductive-aged women in the general population and that there is a substantial overlap between them. 4,5 In the present study, PCOS is defined based on the Rotterdam classification (ESHRE/ASRM), 2003 6 and MS is defined based on the International Diabetes Federation (IDF) definition Its clinical significance, although still debatable, lies in the fact that MS may predict a higher risk for cardiovascular events than the sum of the risks imparted by its individual components. According to one careful estimate, around 25% of world population has symptoms clearly indicative of MS. 7 Not surprisingly; untreated MS increases the risk of coronary and cerebro-vascular complications including death.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 MS has exponentially increased in prevalence during the last few years and women have seen a particularly larger share of this increase, especially in the younger age group. 5,8,9 The rationale of this study is to determine the frequency of MS in patients with PCOS in order to establish the local perspective as there is paucity of local data. In a recent study, the prevalence of PCOS was found to be higher in Pakistani women (52%) than among Western Caucasian women (20%-25%) in the UK.…”

Section: Introductionmentioning

confidence: 99%

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Association of Polycystic Ovarian Syndrome with Metabolic Disorders

Khan¹,

Bano²,

Chughani³

et al. 2022

J. Bahria Uni. Med. Dent. Coll.

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Objective: To determine the association of Metabolic Disorders in women of reproductive age with polycystic ovarian syndrome (PCOS) Study Design and setting: Cross Sectional Study conducted in the Department of Gynecology and Obstetrics, Ward 9, Jinnah Postgraduate Medical Center, Karachi. Methodology: The study was conducted from November 2021 to February 2022. A total of 227 diagnosed patients of PCOS were included in this study. Five components of Metabolic syndrome were assessed: Body Mass Index (BMI), blood pressure, central obesity, fasting blood sugar and lipid profile. Informed consent was obtained from all participants. Patients’ history, physical examination and laboratory investigations in terms of symptoms and findings relating to MS were recorded and assessed using SPSS version 21. Descriptive statistics were calculated and stratification was done. Chi-square test used post stratification and p-value =0.05 were considered significant. Results: Mean age was 27.05±4.51 years. Mean symptom duration was 11.26±3.02 months. Central obesity, hypertension, hypertriglyceridemia, HDL-cholesterol <50 mg/dl and fasting glucose >100 mg/dl were found in 44.9%, 31.7%, 38.3%, 27.3%, and 38.8% patients, respectively. A total of 47 (20.7%) study subjects were identified with two or more above components of MS. Significant association of MS with age (>27 years; p<0.000) and duration of disease (>12 months; p<0.000) was observed. Conclusion: A higher prevalence of MS was observed when participants aged more than 27 years and had symptoms for more than a year. Higher BMI was also found nearing statistical significance

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“…4 Polycystic appearances in ovaries were noted in 33.3 percent of the study populace in a study carried out at Baqai Institute of endocrinology, Karachi. 5 Diagnosis of PCOS is made according to the presence of at least two of the three criteria, i.e., polycystic ovaries on ultrasound, chronic anovulation, and increased androgens according to Rotterdam criteria. 6 Primary Subfertility is diagnosed when a couple has not achieved pregnancy after 2 years of having regular unprotected sex.…”

Section: Introductionmentioning

confidence: 99%

Association of Primary Subfertility in Polycystic Ovarian Syndrome with BMI and Waist Circumference

Waheed¹,

Muhabat²,

Bhatti³

et al. 2021

PJMHS

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Background: To determine the association of primary subfertility in Polycystic Ovaries with BMI and waist circumference. Methods: This cross-sectional study was performed from 01-08-2018 to 01-08-2019 at the Department of Obstetrics & Gynecology, Indus Medical College, Tando Muhammad Khan on (n=245) diagnosed with polycystic ovaries in the age group of 18 to 49 years. The study population, having diabetes mellitus, increased prolactin levels, disturbed thyroid function, congenital adrenal hyperplasia, and the couples with contraceptive measures were not included. Mean ± SD was computed for numerical data, frequencies and percentages were computed for qualitative data. Chi-square was used as a test of significance with a P-value <0.05 as significant. Results: The mean ± SD age of these women was 33.46±6.71 years with a range from 18 to 45 years. The proportion of subfertility in PCOS was 40.41%. The frequency of subfertility in PCO increases from normal weight to obesity significantly. (P-value <0.01) Additionally; women presenting with PCOS and increased waist circumference had a higher frequency of subfertility. (P-value <0.01). Conclusion: A much higher proportion of women with PCOS who present with obesity, overweight, and higher waist circumference were subfertile. With early screening and treatment for PCOS, weight control also is necessary to prevent the big issue of subfertility. Keywords: Obesity, Polycystic Ovarian Syndrome. Subfertility.

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Clinical Presentation and Frequency of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: An Experience From a Tertiary Care Hospital in Pakistan

Abstract: Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. The aim of this study was to determine the variations in the clinical presentation and frequency of metabolic syndrome (MetS) in women with PCOS.

Cited by 11 publications

References 26 publications

Insulin Resistance in young obese females with and without Polycystic Ovary Syndrome.

Insulin Resistance in young obese females with and without Polycystic Ovary Syndrome.

Association of Polycystic Ovarian Syndrome with Metabolic Disorders

Association of Primary Subfertility in Polycystic Ovarian Syndrome with BMI and Waist Circumference

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