Level of Chemerin and Anti-Müllerian Hormone in Egyptian Obese Women with Polycystic Ovarian Syndrome

Abstract

Background: Chemerin is a newly discovered adipokine that regulates adipocyte development, metabolic function as well as immune function. Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that belongs to the transforming growth factor-beta family. Aim of the study: was to evaluate the serum levels of Chemerin and AMH in one trial to show their possible involvement in the pathogenesis of PCOS and their association with obesity. Subjects and methods: This study was performed on eighty subjects divided into 4 groups: Group I: 20 nonobese control (BMI< 30), Group II: 20 non-obese patient with polycystic ovarian syndrome (BMI< 30), Group III: 20 obese Control (BMI ≥ 30) and Group IV: 20 obese patient with PCOS (BMI ≥ 30). Serum levels of Chemerin and AMH were estimated by ELISA. Results: Results showed a significant increase in serum levels of Chemerin and AMH in (non-obese and obese) PCOS groups when compared to their controls. Results showed also a significant increase in the serum level of Chemerin in obese PCOS group when compared to non-obese PCOS group. While a significant decrease in serum level of AMH in obese PCOS group when compared to non-obese PCOS group. There were a significant positive correlation between Chemerin and AMH in PCOS groups. Conclusion: Chemerin together with AMH may be used as a biomarker for early detection of PCO and Clinical parameters as Infertility and Hyper and rogenism in women with PCOS.

Evaluation of Serum Omentin-1 and Apelin Levels and Their Association With Insulin Resistance and Obesity in Egyptian Women With Polycystic Ovary Syndrome

“…PCOS groups showed significant increase in TC, TAG, LDL-C and significant decrease in HDL-C in obese women when compared to the non-obese women, similar results were found in studies done by Foda et al 3 Regarding the hormonal profile the present results revealed significant increases in serum LH and total testosterone levels and no significant differences in serum FSH and progesterone levels between PCOS patients compared with control subjects. These results are in agreeing with Hasan and El Hameed, Sun et al and El Omda et al 10,21,22 . Coutinho and Kauffman reported that in the polycystic ovary syndrome LH pulse frequency and amplitude are higher throughout the menstrual cycle in comparison to that observed in healthy women 23 .…”

Serum and follicular fluid chemerin and chemerin mRNA expression in women with polycystic ovary syndrome: Systematic review and meta‐analysis

“…In total, serum and FF chemerin levels were measured in nineteen 16‐18,32,33,35‐48 and four studies, 10,18,34,49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10,16‐18,32‐48 or Wb 49 .…”

“…In total, serum and FF chemerin levels were measured in nineteen 16‐18,32,33,35‐48 and four studies, 10,18,34,49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10,16‐18,32‐48 or Wb 49 . However, in total, five studies assessed chemerin mRNA expression in the subcutaneous and omental adipose tissues 17,32 and ovarian (granulosa cells in follicular fluid) 10,18,34 using reverse transcription‐polymerase chain reaction (RT‐PCR), due to the lack of data, only ovarian chemerin mRNA expression was analysed.…”

“…In total, serum and FF chemerin levels were measured in nineteen 16 , 17 , 18 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 and four studies, 10 , 18 , 34 , 49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10 , 16 , 17 , 18 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 or Wb.…”

“…In total, serum and FF chemerin levels were measured in nineteen 16 , 17 , 18 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 and four studies, 10 , 18 , 34 , 49 respectively. The methods of assessing serum and FF chemerin levels were ELISA 10 , 16 , 17 , 18 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 or Wb. 49 However, in total, five studies assessed chemerin mRNA expression in the subcutaneous and omental adipose tissues 17 , 32 and ovarian (granulosa cells in follicular fluid) 10 , 18 , 34 using reverse transcription‐polymerase chain reaction (RT‐PCR), due to...…”