Preparation of magnetic mesoporous silica nanoparticles as a multifunctional platform for potential drug delivery and hyperthermia

Abstract

We report the preparation of magnetic mesoporous silica (MMS) nanoparticles with the potential multifunctionality of drug delivery and magnetic hyperthermia. Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO2), and the rattle-type structured MMS nanoparticles (MCN/mSiO2) were obtained after the removal of the carbon layers from MCN@C/mSiO2 nanoparticles. The morphology, structure, magnetic hyperthermia ability, drug release behavior, in vitro cytotoxicity and cellular uptake of MMS nanoparticles were investigated. The results revealed that the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles had spherical morphology and average particle sizes of 390 and 320 nm, respectively. The MCN@C/mSiO2 nanoparticles exhibited higher magnetic hyperthermia ability compared to the MCN/mSiO2 nanoparticles, but the MCN/mSiO2 nanoparticles had higher drug loading capacity. Both MCN@C/mSiO2 and MCN/mSiO2 nanoparticles had similar drug release behavior with pH-controlled release and temperature-accelerated release. Furthermore, the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles showed low cytotoxicity and could be internalized into HeLa cells. Therefore, the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles would be promising for the combination of drug delivery and magnetic hyperthermia treatment in cancer therapy.

Recent Advances in the Synthesis, Surface Modifications and Applications of Core‐Shell Magnetic Mesoporous Silica Nanospheres

“…Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO 2 ), and the rattle-type structured MMS nanoparticles (MCN/mSiO 2 ) were obtained after the removal of the carbon layers from MCN@C/mSiO 2 nanoparticles. [119] As a result, MCN@C/mSiO 2 nanospheres and MCN/mSiO 2 nanospheres have similar drug release behavior, and both hold the function of controlling pH release and accelerated the temperature release. The results show that MCN@C/mSiO 2 and MCN/mSiO 2 nanospheres are expected to be utilized for drug delivery and magnetic hyperthermia in cancer therapy.…”

<p>Multimodal Mesoporous Silica Nanocarriers for Dual Stimuli-Responsive Drug Release and Excellent Photothermal Ablation of Cancer Cells</p>

“…Nonetheless, magnetic NPs have several advantages in drug delivery systems: i) facile separation by a simple magnetic manipulation, ii) magnetic-targeting capability, and iii) high NIR absorption and conversion into thermal energy. 18,52 FTIR Analysis -SEM and TEM Images FTIR spectrum was measured to characterize the surface modifications at each synthetic step. As shown in Figure 2A-1, the characteristic peaks corresponding to the antisymmetric and symmetric stretching vibrations of the Si-O-Si bond in oxygen-silica tetrahedron were clearly observed at 1,078 and 791 cm −1 , respectively.…”

“…These core-shell type MSNs can be promising theranostic nanocarriers with high loading capability, cell targeting specificity, and bio-imaging agents, as well as by adding stimuli-responsive drug release and hyperthermia treatment. [16][17][18][19][20] Graphene oxide (GO) possesses advantageous biocompatibility, large specific surface area, and π-conjugated nanostructures which can confer excellent water solubility, physiological stability, and capacity for drug delivery. 21,22 Likewise, polydopamine (PDA) possess good biocompatibility, unique chemical structure, and photothermal heating effects, which can be rapidly integrated into the construction of tumor-targeted drug delivery systems.…”

Targeted Magnetic Nanotheranostics of Cancer

“…The MCN@C/mSiO 2 nanoparticles exhibited higher magnetic hyperthermia ability compared to the MCN/mSiO 2 nanoparticles, but the MCN/mSiO 2 nanoparticles had higher drug loading capacity. Research has shown that drug release from the two types of complexes were temperature-dependent [ 26 ].…”

“…One of the most studied areas of medicine is tumor targeted drug delivery [ 12 , 13 , 19 , 20 , 21 ]. Moreover, targeted drug delivery is often used in conjunction with hyperthermia [ 17 , 22 , 23 , 24 , 25 , 26 ].…”