Targeted Magnetic Nanotheranostics of Cancer

Belyanina, Irina V.; Kolovskaya, Olga S.; Zamay, Sergey S.; Gargaun, Ana; Zamay, Tatiana N.; Kichkailo, Anna S.

doi:10.3390/molecules22060975

Cited by 38 publications

(28 citation statements)

References 118 publications

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“…SERS comprises a vibrational spectroscopy technique of molecular signal amplification, with potential for in vivo imaging [99]. SERS uses the inelastic light scattering of photons that interact with matter, such as MNPs, to retrieve information about the surface characteristics and components.…”

Section: Medical Applicationsmentioning

confidence: 99%

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

2020

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Technological development is in constant progress in the oncological field. The search for new concepts and strategies for improving cancer diagnosis, treatment and outcomes constitutes a necessary and continuous process, aiming at more specificity, efficiency, safety and better quality of life of the patients throughout the treatment. Nanotechnology embraces these purposes, offering a wide armamentarium of nanosized systems with the potential to incorporate both diagnosis and therapeutic features, towards real-time monitoring of cancer treatment. Within the nanotechnology field, magnetic nanosystems stand out as complex and promising nanoparticles with magnetic properties, that enable the use of these constructs for magnetic resonance imaging and thermal therapy purposes. Additionally, magnetic nanoparticles can be tailored for increased specificity and reduced toxicity, and functionalized with contrast, targeting and therapeutic agents, revealing great potential as multifunctional nanoplatforms for application in cancer theranostics. This review aims at providing a comprehensive description of the current designs, characterization techniques, synthesis methods, and the role of magnetic nanoparticles as promising nanotheranostic agents. A critical appraisal of the impact, potentialities and challenges associated with each technology is also presented.

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Section: Medical Applicationsmentioning

confidence: 99%

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

2020

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“…Thus, MNPs are constructed using biocompatible shells of polymers or metals, as well as nanocomposite mixtures consisting of MNPs encapsulated within porous polymers. Presence of the polymers or other coatings provides an opportunity to anchor various therapeutic drugs or DNA for targeted gene delivery [84,85]. Figure 7 is a suggestive representation of the multiple possibilities of MNPs' functionalization for application in cancer detection and treatment [85].…”

Section: Drug Deliverymentioning

confidence: 99%

“…Presence of the polymers or other coatings provides an opportunity to anchor various therapeutic drugs or DNA for targeted gene delivery [84,85]. Figure 7 is a suggestive representation of the multiple possibilities of MNPs' functionalization for application in cancer detection and treatment [85]. In chemotherapy, anticancer drugs are administered through the venous circulatory system, strategy that aims at the accumulation of the drugs in the tumors, where vascularization is accentuated compared to healthy tissues.…”

Section: Drug Deliverymentioning

confidence: 99%

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Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019

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During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

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“…The dreaded complication of nephrogenic systemic fibrosis (NSF) often prohibits the use of Gd‐based contrast agents in patients with renal failure . To overcome these limitations, newer MR‐based contrast agents are being developed, including newer magnetic NPs (MNPs), which are often functionalized to target a specific biological target …”

Section: Nanoprobes For Cancer Multimodal Imagingmentioning

confidence: 99%

Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer

Liu

Anderson

Lan

et al. 2019

Medicinal Research Reviews

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This review explores recent work directed toward the development of nanoparticles (NPs) for multimodality cancer imaging and targeted cancer therapy. In the growing era of precision medicine, theranostics, or the combined use of targeted molecular probes in diagnosing and treating diseases is playing a particularly powerful role. There is a growing interest, particularly over the past few decades, in the use of NPs as theranostic tools due to their excellent performance in receptor target specificity and reduction in off-target effects when used as therapeutic agents. This review discusses recent advances, as well as the advantages and challenges of the application of NPs in cancer imaging and therapy.

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Targeted Magnetic Nanotheranostics of Cancer

Cited by 38 publications

References 118 publications

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer

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