The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

Ferreira, Maria Inês; Sousa, João; Pais, Alberto A. C. C.

doi:10.3390/ma13020266

Cited by 62 publications

(50 citation statements)

References 103 publications

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“…Generation and genetic modification of iPSCs are essential procedures for studies and applications of hiPSCs in biomedicine, which rely on the technical advances in the field to facilitate and promote the iPSC biology. Nanoparticles have diverse applications in biomedicine including nanoprobes and sensors, enhanced imaging, magnetic separation, drug and transgene delivery, hyperthermia and cancer therapy [ 19 , 52 , 53 , 55 , 56 , 77 , 81 , 112 , 114 , 130 , 131 , 132 ]. The most successful example is the recent development of SARS-CoV-2 vaccines as we discussed above.…”

Section: Discussionmentioning

confidence: 99%

“…New technologies based on nanotechnology have been transformed into numerous biological applications, and the use of nanoparticles for targeted delivery has undoubtedly improved drug delivery capabilities. Magnetic nanoparticles are of particular interest due to their ability to be drawn to specific tissues reliably and with little disruption to the tissue itself [ 52 , 53 , 54 , 55 , 56 ]. As such, they represent an important branch within nanotechnology with significant potential for application, for example, in transfection of hiPSCs.…”

Section: Nanoparticles In Biomedicinementioning

confidence: 99%

“…The essential magnetic properties of nanoparticles offer potential application possibilities which are of great biomedical interest [ 77 ]. Magnetic nanoparticles have application in in vivo imaging, targeted drug delivery, transgene delivery, and image guided diagnosis and therapy [ 52 , 53 , 54 , 55 , 56 , 75 , 77 ]. They were also used in a range of cells, from cancerous cells to hiPSCs and hiPSC-derived cells.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

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Transgene Delivery to Human Induced Pluripotent Stem Cells Using Nanoparticles

2021

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Human induced pluripotent stem cells (HiPSCs) and HiPSCs-derived cells have the potential to revolutionize regenerative and precision medicine. Genetically reprograming somatic cells to generate HiPSCs and genetic modification of HiPSCs are considered the key procedures for the study and application of HiPSCs. However, there are significant technical challenges for transgene delivery into somatic cells and HiPSCs since these cells are known to be difficult to transfect. The existing methods, such as viral transduction and chemical transfection, may introduce significant alternations to hiPSC culture which affect the potency, purity, consistency, safety, and functional capacity of HiPSCs. Therefore, generation and genetic modification of HiPSCs through non-viral approaches are necessary and desirable. Nanotechnology has revolutionized fields from astrophysics to biology over the past two decades. Increasingly, nanoparticles have been used in biomedicine as powerful tools for transgene and drug delivery, imaging, diagnostics, and therapeutics. The most successful example is the recent development of SARS-CoV-2 vaccines at warp speed to combat the 2019 coronavirus disease (COVID-19), which brought nanoparticles to the center stage of biomedicine and demonstrated the efficient nanoparticle-mediated transgene delivery into human body. Nanoparticles have the potential to facilitate the transgene delivery into the HiPSCs and offer a simple and robust approach. Nanoparticle-mediated transgene delivery has significant advantages over other methods, such as high efficiency, low cytotoxicity, biodegradability, low cost, directional and distal controllability, efficient in vivo applications, and lack of immune responses. Our recent study using magnetic nanoparticles for transfection of HiPSCs provided an example of the successful applications, supporting the potential roles of nanoparticles in hiPSC biology. This review discusses the principle, applications, and significance of nanoparticles in the transgene delivery to HiPSCs and their successful application in the development of COVID-19 vaccines.

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Section: Discussionmentioning

confidence: 99%

Section: Nanoparticles In Biomedicinementioning

confidence: 99%

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

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Transgene Delivery to Human Induced Pluripotent Stem Cells Using Nanoparticles

2021

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“…To overcome these drawbacks related to the in vivo utilization of MNPs, the surface of MNPs is often modified by capping specific layers to improve their stability and biocompatibility, inhibit nonspecific protein absorbance, and prolong their blood circulation time. [ 12 ] Precise surface functionalization can be attained through the use of different design materials, such as organic ligands (e.g., synthetic polymer, [ 13 ] small molecules, [ 14 ] biomacromolecules [ 15 ] ), organic–inorganic hybrid NPs (e.g., metal–organic frameworks (MOFs)), [ 16 ] and inorganic NPs [ 17 ] (e.g., silica, [ 18 ] gold, [ 19 ] quantum dot, [ 20 ] ). Among these materials, organic ligands exhibit huge advantages in facilitating various biological and biomedical applications [ 21 ] because their properties can well endow MNPs with controlled structure, the desired size, and surface charge, as well as programmed responses to tumor microenvironments (e.g., pH, redox, reactive oxygen species (ROS)).…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

Yang

Lee

2021

Advanced NanoBiomed Research

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Functionalization of magnetic nanoparticles (MNPs) with organic ligands to prepare personalized nanomedicine has attracted tremendous attention in biomedical applications. These organic/MNP nanohybrid platforms not only can exert the superparamagnetic property of MNPs for diagnosis imaging and treatment, but are also endowed with the merits of organic ligands for improved tumor‐targeting ability, blood circulation time, and cellular uptake. Flexibly manipulating the interactions between different inorganic ligands and MNPs to establish a single MNP matrix or multiple MNP assemblies presents advanced strategies in controlling their composition and chemical–physical and biological properties for various biomedical applications. Beginning with a brief introduction to a variety of strategies for the efficient functionalization of MNPs with various organic ligands, herein, the recent progress in the development and biomedical applications of the different types of nanoplatforms of organic ligand–mediated MNPs is briefly introduced, including diagnosis, therapy, imaging‐guided therapy, and drug delivery. Finally, the future opportunities and challenges for next‐generation high‐performance organic ligand–functionalized MNP nanoplatforms are also discussed.

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“…Chemotherapy induces peripheral neuropathy [1,2]. Taxol (paclitaxel) is a common microtubule-binding antineoplastic drug used to treat solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Effects of Electrical Stimulation on Peripheral Nerve Regeneration in a Silicone Rubber Conduit in Taxol-Treated Rats

et al. 2020

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Taxol, a type of antimitotic agent, could modulate local inflammatory conditions in peripheral nerves, which may impair their regeneration and recovery when injured. This study provided in vivo trials of silicone rubber chambers to bridge a long 10 mm sciatic nerve defect in taxol-treated rats. It was aimed to determine the effects of electrical stimulation at various frequencies on regeneration of the sciatic nerves in the bridging conduits. Taxol-treated rats were divided into four groups (n = 10/group): sham control (no current delivered from the stimulator); and electrical stimulation (3 times/week for 3 weeks at 2, 20, and 200 Hz with 1 mA current intensity). Neuronal electrophysiology, animal behavior, neuronal connectivity, macrophage infiltration, calcitonin gene-related peptide (CGRP) expression levels, and morphological observations were evaluated. At the end of 4 weeks, animals in the low- (2 Hz) and medium-frequency (20 Hz) groups had dramatic higher rates of successful regeneration (90% and 80%) across the wide gap as compared to the groups of sham and high-frequency (200 Hz) (60% and 50%). In addition, the 2 Hz group had significantly larger amplitudes and evoked muscle action potentials compared to the sham and the 200 Hz group, respectively (P < 0.05). Heat, cold plate licking latencies, motor coordination, and neuronal connectivity were unaffected by the electrical stimulation. Macrophage density, CGRP expression level, and axon number were all significantly increased in the 20 Hz group compared to the sham group (P < 0.05). This study suggested that low- (2 Hz) to medium-frequency (20 Hz) electrical stimulation could ameliorate local inflammatory conditions to augment recovery of regenerating nerves by accelerating their regrowth and improving electrophysiological function in taxol-treated peripheral nerve injury repaired with the silicone rubber conduit.

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The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

Cited by 62 publications

References 103 publications

Transgene Delivery to Human Induced Pluripotent Stem Cells Using Nanoparticles

Transgene Delivery to Human Induced Pluripotent Stem Cells Using Nanoparticles

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

Effects of Electrical Stimulation on Peripheral Nerve Regeneration in a Silicone Rubber Conduit in Taxol-Treated Rats

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