Recent Advances in the Synthesis, Surface Modifications and Applications of Core‐Shell Magnetic Mesoporous Silica Nanospheres

Abstract

The hierarchically structured core-shell magnetic mesoporous silica nanospheres (Mag-MSNs) have attracted extensive attention, particularly in studies involving reliable preparations and diverse applications of the multifunctional nanomaterials in multi-disciplinary fields. Intriguingly, Mag-MSNs have been prepared with well-designed synthesis strategies and used as adsorbent materials, biomedicines, and in proteomics and catalysis due to their excellent magnetic responsiveness, enormous specific surface area and readiness for surface modifications. Through a carefully designed surface modification of Mag-MSNs, the performance and application prospects of the material are greatly improved. Typically, the introduction of various molecular matrices into the shell of Mag-MSNs facilitates the combination of surface modifications and magnetic separation technology. So far, as sustainable chemistry is concerned, it is important to recover the functionalized core-shell Mag-MSNs after the reaction and reuse them without losing activity. In this review, the design conceptions and the construction of core-shell Mag-MSNs are discussed. Furthermore, various surface modification approaches of core-shell Mag-MSNs are summarized, and recent applications of these functionalized nanomaterials in the fields of biomedicine, catalysis, proteomics and wastewater treatment are exemplified. 2 3 4 5 6 7 8

Loading and Release of Charged and Neutral Fluorescent Dyes into and from Mesoporous Materials: A Key Role for Sensing Applications

“…However, in the last years the scope of this technology has been expanded toward applications in a variety of sectors such as agriculture [3,4], photovoltaic cells [5] external coatings [6] or personal care and cosmetics [7], employing as nanoparticles drug carriers (NPs) of organic [8][9][10] or inorganic [11] nature. Among these materials, microporous and mesoporous materials, due to their chemical inertness, homogeneous porosity and large internal surface area, have attracted considerable research interest for applications on the fields of drug delivery [12][13][14], catalysis [15][16][17], filtration and separation [18,19], gas adsorption [20,21] and storage [22,23], enzyme immobilisation [24,25], biomedical tissue regeneration [26,27], environmental remediation [28][29][30], chemical/biochemical sensing [31][32][33] and theranostics [34,35] mostly as nano-or microparticles, but also in core/shell formats or in combination with other properties such as magnetic ones [36,37]. Whereas typical microporous materials are crystalline framework solids, such as zeolites [38] with pore dimensions between 10-14 Å [39,40], mesoporous silica materials of the MCM-41 type, discovered in 1992 by researchers of the Mobil Research and Development Corporation ...…”

Nanoscale Drug Delivery Systems in Glioblastoma

“…Various magnetic-MSNs were designed and the most common magnetic MSNs were composed of metal core and silica shell in an embedded core–shell manner [ 88 , 89 ]. Apart from that, sandwich-structured [ 90 ], hollow-type [ 91 ] and rattle-type [ 92 ] magnetic MSNs were developed for multidisciplinary applications [ 93 ] while seldom were employed in drug delivery.…”

FNAOSiPPEA[]/Zn(II) as a Bifunctional Lewis Acid/ Bronsted Base Heterogeneous Magnetic Nanocatalyst Based on Nano‐Almond Shell for Synthesis of Naphtho[1,3]oxazine Derivatives**

“…Magnetic nanoparticles (MNPs) have expanded in recent years due to their special physical and chemical properties such as high surface area, and high penetration power, [1,2] The instability of Fe 3 O 4 nanoparticles is still a major challenge in nanoparticles science. For this reason, the surface of magnetic nanoparticles has been modified by coating them with nano‐cellulose, ionic liquids, silica nanoparticles, and polymers [3–9] . Nano‐cellulose (NC) has been reported as coating for magnetic nanoparticles due to their high O−H functional groups.…”

“…For this reason, the surface of magnetic nanoparticles has been modified by coating them with nanocellulose, ionic liquids, silica nanoparticles, and polymers. [3][4][5][6][7][8][9] Nano-cellulose (NC) has been reported as coating for magnetic nanoparticles due to their high OÀ H functional groups. NCs are abundant biopolymers that can be extracted from bacteria, algae, wood, cotton, and agricultural residues.…”