Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis

Zhang, Yiyao; Zhang, Peng; Gao, Xiuqiu; Chang, Linna; Chen, Zhenhua; Mei, Xifan

doi:10.1016/j.msec.2020.111671

Cited by 73 publications

(44 citation statements)

References 43 publications

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“…For example, exosomes isolated from human umbilical cord-derived MSCs encapsulated in polyvinyl alcohol (PVA)/Alg nanohydrogels were used to heal diabetic wounds. 64 The PVA/Alg nanohydrogel promoted cell proliferation, migration and angiogenesis, enhanced the efficacy of exosomes, and accelerated healing of diabetic wounds. In another study, exosomes were loaded in a novel injectable bioactive hydrogel called FHE.…”

Section: Tissue Engineering Applications Of Exosome-laden Scaffoldsmentioning

confidence: 99%

Cell-free exosome-laden scaffolds for tissue repair

et al. 2021

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Section: Tissue Engineering Applications Of Exosome-laden Scaffoldsmentioning

confidence: 99%

Cell-free exosome-laden scaffolds for tissue repair

et al. 2021

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“…Exosomes with a diameter of 30-100 nm, which are secreted from stem cells, exhibit a lower immunogenic response and are easier to maintain bioactivity during storage than stem cells [91]. Exosomes derived from human umbilical cord mesenchymal stem cells were encapsulated in polyvinyl alcohol/alginate nano hydrogel, with the results showed that it contributed to angiogenesis and wound healing in SD rats by activating the ERK1/2 pathway [92]. In the Wistar rat model, infiltration of exosomes from ADSCs with sodium alginate hydrogel enhanced wound closure and angiogenesis, with a wound closure percentage of 94.80 ± 1.07% at 14 days [93].…”

Section: Stem Cell-seeded Scaffoldsmentioning

confidence: 99%

Advances in Skin Wound and Scar Repair by Polymer Scaffolds

et al. 2021

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Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored. Polysaccharide and protein scaffolds, an analog of extracellular matrix, act as templates for cell adhesion and migration, differentiation to facilitate wound reconstruction and limit scarring. Stem cell-seeded scaffolds and growth factors-loaded scaffolds offer significant bioactive substances to improve the wound healing process. Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.

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“…Entrapment of EXOs into polysaccharide-based matrices. In panel (A), the EXOs are mixed into a polymeric solution, then gelled by the addition of a cross-linking agent [128][129][130][131][132][133][134][135][136][137][138][139][140]; in panel (B), the EXOs are directly loaded in a pre-formed gel [141][142][143][144][145][146][147].…”

Section: Polysaccharide-based Hydrogel For Sustained Exosome-based Delivery Systemmentioning

confidence: 99%

“…EXOs derived from human umbilical cord mesenchymal stem cells were encapsulated in PVA/SA nanohydrogel facilitating the proliferation, migration and angiogenesis of HUVECs. In vivo, EXObased nanohydrogel significantly promoted diabetic wound healing by increasing the expression of molecules related to angiogenesis and activating ERK1/2 pathway [138]. A combined approach provides for the addition of cellular components to vesicles-modified scaffolds.…”

Section: Polysaccharide-based In Situ Gelling System For a Sustained Delivery Of Exosomesmentioning

confidence: 99%

From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides

2021

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Exosomes (EXOs) are nano-sized informative shuttles acting as endogenous mediators of cell-to-cell communication. Their innate ability to target specific cells and deliver functional cargo is recently claimed as a promising theranostic strategy. The glycan profile, actively involved in the EXO biogenesis, release, sorting and function, is highly cell type-specific and frequently altered in pathological conditions. Therefore, the modulation of EXO glyco-composition has recently been considered an attractive tool in the design of novel therapeutics. In addition to the available approaches involving conventional glyco-engineering, soft technology is becoming more and more attractive for better exploiting EXO glycan tasks and optimizing EXO delivery platforms. This review, first, explores the main functions of EXO glycans and associates the potential implications of the reported new findings across the nanomedicine applications. The state-of-the-art of the last decade concerning the role of natural polysaccharides—as targeting molecules and in 3D soft structure manufacture matrices—is then analysed and highlighted, as an advancing EXO biofunction toolkit. The promising results, integrating the biopolymers area to the EXO-based bio-nanofabrication and bio-nanotechnology field, lay the foundation for further investigation and offer a new perspective in drug delivery and personalized medicine progress.

show abstract

Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis

Cited by 73 publications

References 43 publications

Cell-free exosome-laden scaffolds for tissue repair

Cell-free exosome-laden scaffolds for tissue repair

Advances in Skin Wound and Scar Repair by Polymer Scaffolds

From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides

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