Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored. Polysaccharide and protein scaffolds, an analog of extracellular matrix, act as templates for cell adhesion and migration, differentiation to facilitate wound reconstruction and limit scarring. Stem cell-seeded scaffolds and growth factors-loaded scaffolds offer significant bioactive substances to improve the wound healing process. Special emphasis is placed on scaffolds that continuously release oxygen, which greatly accelerates the vascularization process and ensures graft survival, providing convincing theoretical support and great promise for scarless healing.
The use of natural silk nanofibers (SNFs) in flexible materials has been widely studied in recent years. However, the reported preparation methods are not suitable for commercial consideration. We report a method for rapid preparation of silk nanofibers in water. Silk nanofibers were mixed with graphene to prepare composite conductive silk films (CSF) with good flexibility and conductivity. Micro-morphology shows that graphene is embedded and modified between silk nanofibers to form a stable structure. Infrared analysis showed that graphene compounds do not alter silk formation, especially in the stable silk structure. Resistance tests show that the process is most effective when the ratio of SNFs to graphene is 1:3. This study offers a new approach to fabricating bioelectric devices.
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