Preparation of antibacterial PCL/PVP-AgNP Janus nanofibers by uniaxial electrospinning

Li, Rui; Cheng, Zhiqiang; Yu, Xiaobin; Wang, Shang; Han, Zhaolian; Kang, Lijuan

doi:10.1016/j.matlet.2019.07.075

Cited by 52 publications

(30 citation statements)

References 6 publications

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“…The above two electrospinning techniques are a well-known method for preparing Janus nanofibers. Recently, Li et al (146) reported that PCL/PVP-AgNP Janus nanofibers with hydrophobicity and hydrophilicity were successfully prepared by uniaxial electrospinning using phase separation in solution. The schematic diagram of the preparation of PCL/PVP-AgNP Janus nanofibers is revealed in Figure 15a.…”

Section: Janus Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

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Electrospinning as one of the most versatile technologies have attracted a lot of scientists’ interests in past decades due to its great diversity of fabricating nanofibers featuring high aspect ratio, large specific surface area, flexibility, structural abundance, and surface functionality. Remarkable progress has been made in terms of the versatile structures of electrospun fibers and great functionalities to enable a broad spectrum of applications. In this article, the electrospun fibers with different structures and their applications are reviewed. First, several kinds of electrospun fibers with different structures are presented. Then the applications of various structural electrospun fibers in different fields, including catalysis, drug release, batteries, and supercapacitors, are reviewed. Finally, the application prospect and main challenges of electrospun fibers are discussed. We hope that this review will provide readers with a comprehensive understanding of the structural design and applications of electrospun fibers in different fields.

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Section: Janus Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

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“…In uniaxial electrospinning, the drug migrates to the surface of the fibre and forms high concentrations, as shown in Figure 4(a). This is commonly seen when small hydrophilic molecules are applied to the matrix 88 . Consequently, an ideal controlled drug release is difficult to achieved, as a burst release tends to occur initially.…”

Section: Fabrication Processmentioning

confidence: 99%

Engineering and polymeric composition of drug‐eluting suture: A review

Deng

Qasim

Ali

2021

J Biomedical Materials Res

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Sutures are the most popular surgical implants in the global surgical equipment market. They are used for holding tissues together to achieve wound closure. However, controlling the body's immune response to these “foreign bodies” at site of infection is challenging. Natural polymers such as collagen, silk, nylon, and cotton, and synthetic polymers such as polycaprolactone, poly(lactic‐co‐glycolic acid), poly(p‐dioxanone) and so forth, contribute the robust foundation for the engineering of drug‐eluting sutures. The incorporation of active pharmaceutical ingredients (APIs) with polymeric composition of suture materials is an efficient way to reduce inflammatory reaction in the wound site as well as to control bacterial growth, while allowing wound healing. The incorporation of polymeric composition in surgical sutures has been found to add high flexibility as well as excellent physical and mechanical properties. Fabrication processes and polymer materials allow control over drug‐eluting profiles to effectively address wound healing requirements. This review outlines and discusses (a) polymer materials and APIs used in suture applications, including absorbable and nonabsorbable sutures; (b) suture structures, such as monofilament, multifilament, barded and smart sutures; and (c) the existing manufacturing techniques for drug‐eluting suture production, including electrospinning, melt‐extrusion and coating.

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“…Also, Jia et al obtained PCL/PVP scaffolds containing silver nanoparticles with polymer ratios of 90/10, 85/15, 80/20, and 70/30 from the solution in dichloromethane 26 . Other researchers used dimethylformamide/chloroform (1/4, w/w) mixture for the preparation of PCL/PVP scaffolds doped with silver nanoparticles 27 …”

Section: Introductionmentioning

confidence: 99%

“…26 Other researchers used dimethylformamide/chloroform (1/4, w/w) mixture for the preparation of PCL/PVP scaffolds doped with silver nanoparticles. 27 Thus, PCL/PVP materials show high potential to be successfully applied in the area of regenerative medicine and drug delivery. At the same time, the available studies either do not address the effect of the PCL/PVP ratio in the spinning solution on key properties of the final material or employ optimized regimes for each polymer proportion.…”

Section: Introductionmentioning

confidence: 99%

Enhanced properties of poly(ε‐caprolactone)/polyvinylpyrrolidone electrospun scaffolds fabricated using 1,1,1,3,3,3‐hexafluoro‐2‐propanol

Goreninskii

Danilenko

Bolbasov

et al. 2021

J of Applied Polymer Sci

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Poly(ε‐caprolactone)/polyvinylpyrrolidone (PCL/PVP) scaffolds with various composition were fabricated from 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) solution using the same electrospinning parameters in order to reveal the effect of polymer ratio on the material properties. The obtained materials were characterized using scanning electron microscopy, contact angle measurements, X‐ray diffraction, Fourier‐transformed infrared spectroscopy, and tensile testing. The strengthening effect of PVP was observed: Young modulus of PCL/PVP scaffold with 50/50 polymer ratio was found at 105.4 ± 8.4 MPa which is six times higher comparing to those of PCL scaffold. PVP‐containing scaffolds were extremely hydrophilic with PVP concentration of 5 wt% (vs. 25 wt% in previous reports) leading to full wetting of the material. in vitro studies showed an improved viability of HeLa cells cultured with the composites containing higher concentrations of PVP. Owing to the application of HFIP, PCL‐based materials were loaded with cyclophosphamide for the first time and the PVP‐containing materials demonstrated the intensified initial release of the model compound. Utilizing HFIP for the fabrication of PCL/PVP scaffolds significantly widens their application for drug delivery systems due to a good solubility of proteins, drugs, and other biologically active compounds in this solvent.

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Preparation of antibacterial PCL/PVP-AgNP Janus nanofibers by uniaxial electrospinning

Cited by 52 publications

References 6 publications

Structural design toward functional materials by electrospinning: A review

Structural design toward functional materials by electrospinning: A review

Engineering and polymeric composition of drug‐eluting suture: A review

Enhanced properties of poly(ε‐caprolactone)/polyvinylpyrrolidone electrospun scaffolds fabricated using 1,1,1,3,3,3‐hexafluoro‐2‐propanol

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