Engineering and polymeric composition of drug‐eluting suture: A review

Deng, Xiaoxuan; Qasim, Muhammad; Ali, Azam

doi:10.1002/jbm.a.37194

Cited by 39 publications

(39 citation statements)

References 103 publications

(177 reference statements)

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“…In addition, multiple drugs can be encapsulated directly into the nanofibers 107 . The method of drug release through encapsulation or incorporation of bioactive components in polymeric materials such as nylon sutures is called drug‐eluting 108 . Drug‐eluting is mainly applicable to removing pathogens in the environment of tissues.…”

Section: Regenerative Medicinementioning

confidence: 99%

Nylon—A material introduction and overview for biomedical applications

Shakiba

Ghomi

Khosravi

et al. 2021

Polymers for Advanced Techs

119

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Nylon is a human‐made material and has been applied in many industrial fields. This literature review explores the use of nylon in biomedical applications and discusses the properties and three‐dimensional (3D) printability of this material. Nylon is studied due to its versatility as an engineering plastic that can be easily transformed into fibers, films, and molded parts. Due to nylon's biocompatible nature, it has desirable chemical stability and tunable mechanical properties making this material and its derivatives widely used as sutures, catheters, dentures, and so on. However, the interactions between nylon and human body tissues have yet to be fully understood. Nevertheless, nylon is hybridized with different materials and used as skin dressings. In recent years, nylon composites have been actively researched in tissue engineering as an alternative to metallic implants with an appropriate bioactivity potential for bone growth. As nylon is supposed to be in contact with the tissue for a long time, hence researchers are developing antimicrobial strategies for the nylon materials to even promote their potential a step further. The 3D printing of nylon is currently confined to specific applications due to the printing technology's current limitations.

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Section: Regenerative Medicinementioning

confidence: 99%

Nylon—A material introduction and overview for biomedical applications

Shakiba

Ghomi

Khosravi

et al. 2021

Polymers for Advanced Techs

119

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“…In suture fabrication, the methods of drug loading include initially electrospinning polymer material, then subsequently the suture is coated with drug; alternatively,, the sutures are spun from drug/polymer mixed solution or drug/polymer suspension. The resulting suture is either packaged as a monofilament or braided into multifilament fibers [ 112 ].…”

Section: Drug-eluting Fibersmentioning

confidence: 99%

Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives

Akombaetwa¹,

Bwanga²,

Makoni

et al. 2022

Polymers

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Wounds are a consequence of disruption in the structure, integrity, or function of the skin or tissue. Once a wound is formed following mechanical or chemical damage, the process of wound healing is initiated, which involves a series of chemical signaling and cellular mechanisms that lead to regeneration and/or repair. Disruption in the healing process may result in complications; therefore, interventions to accelerate wound healing are essential. In addition to mechanical support provided by sutures and traditional wound dressings, therapeutic agents play a major role in accelerating wound healing. The medicines known to improve the rate and extent of wound healing include antibacterial, anti-inflammatory, and proliferation enhancing agents. Nonetheless, the development of these agents into eluting nanofibers presents the possibility of fabricating wound dressings and sutures that provide mechanical support with the added advantage of local delivery of therapeutic agents to the site of injury. Herein, the process of wound healing, complications of wound healing, and current practices in wound healing acceleration are highlighted. Furthermore, the potential role of drug-eluting nanofibers in wound management is discussed, and lastly, the economic implications of wounds as well as future perspectives in applying fiber electrospinning in the design of wound dressings and sutures are considered and reported.

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“…The electrospun fibers show fitness Molecules 2021, 26, 4866 2 of 17 in diversified technological fields such as filtration, protective clothing, wound healing, and other biomedical applications [10][11][12][13]. In particular, the use of electrospun fibers is highly promising for scaffolds in tissue engineering and drug delivery [13][14][15][16][17]. High surface area, high drug loading capacity, porosity, simultaneous delivery of different therapeutic agents, adequate mechanical strength, and cost-effectiveness are appealing characteristics for use in drug delivery systems [18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Activity of Curcumin-Loaded Electrospun Nanofibers for the Prevention of the Biofilm-Associated Infections

Salle¹,

Viscusi

Cristo³

et al. 2021

Molecules

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Curcumin extracted from the rhizome of Curcuma Longa has been used in therapeutic preparations for centuries in different parts of the world. However, its bioactivity is limited by chemical instability, water insolubility, low bioavailability, and extensive metabolism. In this study, the coaxial electrospinning technique was used to produce both poly (ε-caprolactone) (PCL)–curcumin and core–shell nanofibers composed of PCL and curcumin in the core and poly (lactic acid) (PLA) in the shell. Morphology and physical properties, as well as the release of curcumin were studied and compared with neat PCL, showing the formation of randomly oriented, defect-free cylindrical fibers with a narrow distribution of the dimensions. The antibacterial and antibiofilm potential, including the capacity to interfere with the quorum-sensing mechanism, was evaluated on Pseudomonas aeruginosa PAO1, and Streptococcus mutans, two opportunistic pathogenic bacteria frequently associated with infections. The reported results demonstrated the ability of the Curcumin-loading membranes to inhibit both PAO1 and S. mutans biofilm growth and activity, thus representing a promising solution for the prevention of biofilm-associated infections. Moreover, the high biocompatibility and the ability to control the oxidative stress of damaged tissue, make the synthesized membranes useful as scaffolds in tissue engineering regeneration, helping to accelerate the healing process.

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Engineering and polymeric composition of drug‐eluting suture: A review

Cited by 39 publications

References 103 publications

Nylon—A material introduction and overview for biomedical applications

Nylon—A material introduction and overview for biomedical applications

Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives

Antimicrobial and Antibiofilm Activity of Curcumin-Loaded Electrospun Nanofibers for the Prevention of the Biofilm-Associated Infections

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