Enhanced properties of poly(ε‐caprolactone)/polyvinylpyrrolidone electrospun scaffolds fabricated using 1,1,1,3,3,3‐hexafluoro‐2‐propanol

Abstract

Poly(ε‐caprolactone)/polyvinylpyrrolidone (PCL/PVP) scaffolds with various composition were fabricated from 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) solution using the same electrospinning parameters in order to reveal the effect of polymer ratio on the material properties. The obtained materials were characterized using scanning electron microscopy, contact angle measurements, X‐ray diffraction, Fourier‐transformed infrared spectroscopy, and tensile testing. The strengthening effect of PVP was observed: Young modulus of PCL/PVP scaffold with 50/50 polymer ratio was found at 105.4 ± 8.4 MPa which is six times higher comparing to those of PCL scaffold. PVP‐containing scaffolds were extremely hydrophilic with PVP concentration of 5 wt% (vs. 25 wt% in previous reports) leading to full wetting of the material. in vitro studies showed an improved viability of HeLa cells cultured with the composites containing higher concentrations of PVP. Owing to the application of HFIP, PCL‐based materials were loaded with cyclophosphamide for the first time and the PVP‐containing materials demonstrated the intensified initial release of the model compound. Utilizing HFIP for the fabrication of PCL/PVP scaffolds significantly widens their application for drug delivery systems due to a good solubility of proteins, drugs, and other biologically active compounds in this solvent.

The enhanced properties and bioactivity of poly-ε-caprolactone/poly lactic-co-glycolic acid doped with carbonate hydroxyapatite–egg white

“…The increase in the swelling ratio was also contributed to by the morphology or porosity of the fiber due to water becoming trapped in the pores. 40…”

“…The increase in the swelling ratio was also contributed to by the morphology or porosity of the ber due to water becoming trapped in the pores. 40 PCL/PLGA/CHA had the highest swelling ratio due to CHA having a hydroxyl group (OH-) and the increased water absorption into the nanobers. 43 Furthermore, PCL/PLGA/CHA/ EW showed the lowest swelling ratio, caused by the addition of the EW composition, which included hydrophobic protein.…”

Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

“…Locilento et al 153 prepared nanofibrous membranes based on PLA and PEO with GSE by the ES technique with antioxidant properties and well-controlled release of GSE, and PLA/PEO nanofibrous membranes loaded with GSE had good hydrophilicity and good cytocompatibility. Goreninskii et al 154 used ES to form PCL/PVP scaffolds with hexafluoroisopropanol as a solvent, which had extreme hydrophilicity and high cellular activity. The PVP-containing materials exhibited enhanced initial release.…”