Preparation of Aluminum Oxide Nanoparticles by Laser Ablation and a Study of Their Applications as Antibacterial and Wounds Healing Agent

Abstract

Aluminum oxide nanoparticles were prepared and characterized with a wide variety of applications. This study aimed at the preparation of AlO 2 nanoparticles by the liquid particles treated with laser (1064 nm), immersed in deionized water at varied laser energy (350 J/cm 2 ) and diverse numbers of 300 pulse. For antimicrobial, antioxidants, animal's model, the prepared nanoparticles were confirmed by using ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD) and scanning electronic microscope (SEM). The antimicrobial activity of synthesized Al 2 O 3 nanoparticles was tested using well diffusion method against three types of bacteria: Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The best concentration of aluminum oxide nanoparticles was 100 mg/mL, which exhibited a higher antibacterial activity against both gram-negative and -positive bacteria. In addition, the results showed that the gram-negative bacteria were more resistible than gram-positive bacteria. The results also indicated that the aluminum oxide nanoparticles possessed antioxidant effects, as investigated by DPPH method. Finally, the wound healing activity of the aluminum oxide nanoparticles was investigated, and the results showed that the aluminum oxide nanoparticles stimulated the wound healing activity by using animal's model. The results presented in this study demonstrated that the aluminum oxide nanoparticles had biomedical applications could be applied in biomedical uses in the future.

Facile synthesis and application of aluminum oxide nanoparticle based biodegradable film

“…The 210 nm maximum absorption peak verifies the presence of the AlO-NPs complex due to the SPR result. [37] The absorption band at pH 7 was 210 nm both in the synthetic CMC and SB-CMC. The increase in DS decreases the absorption rate significantly and agglomeration of AlO-NPs takes place.…”

“…F I G U R E 1 UV-Vis absorption spectra of synthetic CMC and SB-CMC AlO nanoparticle hydrogel indicates the asymmetric stretching of AlO. [37] The band monitor at 800-850 cm À1 signifies the β-glycoside linkage, C C stretching of CMC nanocomposite hydrogel. The band at 1000-1150 cm À1 is because of >CH O CH 2 group.…”

“…The Gram-negative bacteria have an internal small peptidoglycan structure and an external lipopolysaccharides layer (LPS) in the cell wall that is responsible for the resistance of lipophilic solutes, whereas Gram-positive bacteria had an exterior wide peptidoglycan layer, making them extra receptive to these AlO-NPs. [36,37]…”

“…AlO-NPs can be produced from several methods such as ball milling, laser ablation, sol-gel, sputtering hydrothermal in situ, and pyrolysis. [36,37] The objective of this novel study is to compare the synthetic CMC with CMC made from sugarcane bagasse (SB-CMC) through in situ method as a precursor for AlO-NPs hydrogel and further manufacturing of biopolymer nanocomposite film from the hydrogel. The SB-CMC displayed better mechanical properties as compared to the synthetic CMC purchased directly from the market.…”

Preparation and Characterization of Silver Nanoparticle by Cordia myxa Extract and their Study Anticancer, Antioxidant, Antibacterial Activity

“…Nanotechnology has gotten a lot of widespread attention in recent years because of its many beneficial properties, such aseptically, electrical, electronic, chemical stability, and catalytic activity [1,2] . Nanoparticles' unique properties are commonly used in biomedical devices, cosmetics, medicine, and environmental applications [2,3] . The benefits and functions of nano-particles have being determined by their shape and size.…”