Preparation and Characterization of Silver Nanoparticle by Cordia myxa Extract and their Study Anticancer, Antioxidant, Antibacterial Activity

Abstract

The ethanolic extract leaves of the Cordia myxa plant were used to prepare the biosynthesis of silver nanoparticles (Ag-NPs). The detection of Ag-NPs was done using UV, FTIR, and SEM. We evaluated the anti-bacterial property of ethanolic and nano extract against the growth of two types of pathogenic microbes: Gram -ve bacteria (E. coli) and Gram +ve bacteria (S. aureus). The antibacterial activity of the nano extract was high. In vitro, extracts demonstrated strong antioxidant activity against DPPH at a concentration of 0.8mg/ml. The MTT test was utilized to detect the cytotoxicity of nano extract against lung tumor, and the results indicated that nano extract treatment significantly inhibited the growth of cells (A594 cell line) in a concentration dependent manner. The results indicate, nano extract is a particularly valuable source of antiproliferative and cytotoxic agents.