Preparation, characterisation and antioxidant activities of rutin-loaded zein-sodium caseinate nanoparticles

Abstract

Novel rutin-loaded zein-sodium caseinate nanoparticles (ZP) with antioxidant activity in aqueous medium were investigated. The results showed that the sodium caseinate concentrations, dosages of rutin and ethanol volume fractions significantly affected the zein nanoparticles’ characteristics. Concerning the antioxidant properties, the highest values of rutin loaded ZP obtained using 2, 2-diphenyl-1-picrylhydrazyl scavenging and 2 and 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) decolourisation assays were 52.7% and 71.2%, respectively, and the total antioxidant capacity was 0.40 nmol g-1. The results suggest that zein-sodium caseinate nanoparticles can be used as a new nano carrier system for rutin or other water insoluble active ingredients.

An Enhanced Stability Nanoparticle Preparation by Corn Protein Hydrolysate‐Carboxymethyl Chitosan Maillard Conjugates Loaded with Rutin

“…Furthermore, the conjugation of NOCC positively affected the EE. Note that the EE of all the NP types prepared in this work was significantly higher than that of the rutin-loaded zein-sodium caseinate NPs (90%) produced in our earlier paper (Zhang & Han, 2018). Hydrolysis changes the molecular mass and the exposure of hydrophobic areas to the ambient aqueous phase (Saberi, Kadivar, & Keramat, 2008).…”

“…Zein, the primary hoarding protein of corn has always been an absorbing carrier system for function materials in food applications (Francesco, Panayiotis, Veen, & Velikov, ). However, because zein is water insoluble and its isoelectric point is around 6.8, it loses its physical stability when approaching neutral pH, thus leading to particle aggregation and limiting its application as a delivery carrier (Davidov, Joye, Espinal, & McClements, ; Wang & Zhang, ; Wang, Wang, Yang, Guo, & Lin, ; Zhang & Han, ). Thereby, the exploitation of food‐derivative protein hydrolysates or peptides with nano‐carrier systems has drawn special attention due to their underlying benefits involved with higher activities, low molecular weight, high water dissolvability, superior absorption, little or without negative side‐effects, and even smaller particle size (Cai, Zhao, Wang, & Rao, ; Jiao et al., ; Wang et al., ).…”

Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

“…These drawbacks have limited the use of rutin in the pharmaceutical and food industries. Therefore, there is considerable interest in the development of strategies to improve the therapeutic efficacy of rutin, and the potential of nanotechnology for this purpose has been highlighted (Mauludin, Müller, Keck, 2009;Zhang, Han, 2018;Pandey et al, 2018;Ishak, Mostafa, Kamel, 2017). Nanoencapsulation of drugs and bioactive compounds with low solubility, volatility, or viscosity is an important tool to improve these characteristics and control the release profiles.…”

“…Additionally, few studies report the use of natural polymers for nanoencapsulation of rutin (Ahmad et al, 2016;Konecsni, Low, Nickerson, 2012;Oliveira et al, 2016, Zhang, Han, 2018. Bovine serum albumin (BSA) is a non-toxic, biodegradable, and low-cost natural polymer with great potential as a carrier in food and pharmaceutical applications (Jahanshahi, Najafpour, Rahimnejad, 2008;Jun et al, 2011;Wang et al, 2016a).…”

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

“…Due to its ability to form nanoparticles, zein has been used to provide protection, stability, and as a delivery system to bioactive compounds (Wang et al., ). Among the bioactive compounds that have been encapsulated in zein nanoparticles and their respective obtention methods of obtaining are the following: resveratrol by antisolvent precipitation (Huang et al., ); rutin by antisolvent precipitation (Zhang, & Han, ); quercetagetin by antisolvent coprecipitation (Chen et al., ); curcumin by antisolvent precipitation and liquid–liquid dispersion (Hu, Wang, Fernandez, & Luo, ; Xue et al., ; Zou et al., ); vitamin A by phase separation (Park, Park, & Kim, ); vitamin D3 by phase separation (Luo, Teng, & Wang, ); procyanidins by liquid–liquid dispersion (Zou, Li, Percival, Bonard, & Gu, ), Tangeretin by liquid–liquid dispersion (Chen, Zheng, McClements, & Xiao, ); lutein by liquid–liquid dispersion (Chuacharoen & Sabliov, ), and quercetin by the desolvation procedure of an hydroalcoholic solution (Penalva, González‐Navarro, Gamazo, Esparza, & Irache, ). However, the previously noted methods by which zein nanoparticles with bioactive compounds have been obtained do not ensure that the entire solvent is removed from the nanoparticles, and an additional process is used, such as lyophilization, to obtain them in the form of powder, for which electrospraying comprises a technique that eliminates the entirety of the solvent and it can be obtained in powder in a single step.…”