Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

Pedrozo, Regiellen Cristina; Antônio, Emilli; Khalil, Najeh Maissar; Mainardes, Rubiana Mara

doi:10.1590/s2175-97902019000317692

Cited by 37 publications

(27 citation statements)

References 53 publications

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“…Furthermore, the low water solubility of RT should be considered [ 35 ]. To overcome these problems, different delivery systems for RT were studied [ 37 ], such as complexation with β-cyclodextrin [ 38 ] or phospholipids [ 39 ], encapsulation into polymeric nanoparticles [ 40 , 41 ], or nanoemulsions [ 42 ]. In this way, high anti-inflammatory, anti-cancer, and antioxidant activities were observed through different methods of administration [ 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

et al. 2021

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This study was aimed at preparing and characterizing solid lipid nanoparticles loading rutin (RT-SLNs) for the treatment of oxidative stress-induced diseases. Phospholipon 80H® as a solid lipid and Polysorbate 80 as surfactant were used for the SLNs preparation, using the solvent emulsification/diffusion method. We obtained spherical RT-SLNs with low sizes, ranging from 40 to 60 nm (hydrodynamic radius) for the SLNs prepared starting from 2% and 5% (w/w) theoretical amount. All prepared formulations showed negative zeta-potential values. RT was efficiently encapsulated within SLNs, obtaining high encapsulation efficiency and drug content percentages, particularly for SLNs prepared with a 5% theoretical amount of RT. In vitro release profiles and analysis of the obtained data applying different kinetic models revealed Fickian diffusion as the main mechanism of RT release from the SLNs. The morphology of RT-SLNs was characterized by scanning electron microscopy (SEM), whereas the interactions between RT and the lipid matrix were investigated by Raman spectroscopy, evidencing spectral modifications of characteristic bands of RT due to the establishment of new interactions. Finally, antioxidant activity assay on human glioblastoma astrocytoma (U373) culture cells showed a dose-dependent activity for RT-SLNs, particularly at the highest assayed dose (50 μM), whereas the free drug showed the lesser activity.

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Section: Introductionmentioning

confidence: 99%

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

et al. 2021

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“…Pedrozo et al [36], produced bovine serum albumin-based nanoparticles, which contain rutin by nano-spray drying. Rutin corresponds to flavonols classification of flavonoids, which is a hydrophobic molecule.…”

Section: Spray Dryingmentioning

confidence: 99%

Nanotechnology as a Key to Enhance the Benefits and Improve the Bioavailability of Flavonoids in the Food Industry

Ayala-Fuentes

Chávez-Santoscoy

2021

Foods

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Nanotechnology has impacted the food industry, mainly on developing healthier, safer, and high-quality functional food. Flavonoids are valuable compounds present in plants, fruits, grains, roots, stems, tea, and wine, among others; they possess many benefits for health due to their antioxidant properties toward reactive oxygen species, anti-inflammatory, and antiproliferative, among others. These characteristics make flavonoids attractive in various industrial areas such as medicine, nutraceutical, cosmetology, and pharmaceutical. Unfortunately, flavonoids lack long-term stability, are sensitive to light, long periods of darkness with low oxygen concentration, and often present a low water solubility and poor bioavailability. Nanoencapsulation is an alternative to improve bioavailability and sensitivity in the manufacturing process, based on encapsulating substances on a nanoscale. Nanocapsules are a promising strategy in significantly enhancing the delivery of compounds to various sites in the body. The development of biopolymers to encapsulate sensitive compounds is increasing, as well as the search for the non-toxic, biodegradable, natural and biocompatible characteristics of polymers, is fundamental. The present review describes the recent techniques and technologies for the nanoencapsulation of flavonoids. It discusses their potential advantages and possible limitations, compares natural and synthetic biopolymers, and finally, details nanoparticle regulation.

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“…Conversely, BSA-rutin NPs comprised a homogeneous and stable nano-capsule population (PDI 0.27) with a surface charge of −32.1 mV. Rutin entrapment guaranteed a time control release and increased rutin IC50 by two-fold compared with free rutin for 72 h, as determined by ABTS+ assays [ 60 ]. BSA-NPs containing quercetin were developed using the desolvation method, using 8% and 20% glutaraldehyde as the crosslinking agent, resulting in 152 and 132 nm NPs, respectively.…”

Section: Brief Overview Of Nano-encapsulated Polyphenols: Nature and Physiochemical Polymer Benefitsmentioning

confidence: 99%

Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases

et al. 2021

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Polyphenols play a therapeutic role in vascular diseases, acting in inherent illness-associate conditions such as inflammation, diabetes, dyslipidemia, hypertension, and oxidative stress, as demonstrated by clinical trials and epidemiological surveys. The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-κB and PPAR-γ receptor. However, poor polyphenol bioavailability and extensive metabolization restrict their applicability. Polyphenols carried by nanoparticles circumvent these limitations providing controlled release and better solubility, chemical protection, and target achievement. Nano-encapsulate polyphenols loaded in food grade polymers and lipids appear to be safe, gaining resistance in the enteric route for intestinal absorption, in which the mucoadhesiveness ensures their increased uptake, achieving high systemic levels in non-metabolized forms. Nano-capsules confer a gradual release to these compounds, as well as longer half-lives and cell and whole organism permanence, reinforcing their effectiveness, as demonstrated in pre-clinical trials, enabling their application as an adjuvant therapy against cardiovascular diseases. Polyphenol entrapment in nanoparticles should be encouraged in nutraceutical manufacturing for the fortification of foods and beverages. This study discusses pre-clinical trials evaluating how nano-encapsulate polyphenols following oral administration can aid in cardiovascular performance.

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Bovine serum albumin-based nanoparticles containing the flavonoid rutin produced by nano spray drying

Cited by 37 publications

References 53 publications

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

Nanotechnology as a Key to Enhance the Benefits and Improve the Bioavailability of Flavonoids in the Food Industry

Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases

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