Preparation and Microstructural Characterization of Griseofulvin Microemulsions Using Different Experimental Methods: SAXS and DSC

Moghimipour, Eskandar; Salimi, Anayatollah; Changizi, S.

doi:10.15171/apb.2017.034

Cited by 26 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the main goal of the present study was to manufacture SLNs with a better stability, high entrapment efficiency, smaller particles and a narrow sized distribution, different HLB values (between 8 and 16) in the system were produced by using different proportion of binary mixtures of two surfactants with two different HLBs, in order to find the optimum values of HLB that can fulfill the above mentioned requirements such as size, PDI, EE % and zeta potential. Higher EE % may be as a result of the high solubility of naproxen in span 80 [33]. In order to decrease the HLB value of the system, the amount of Span 80 (the surfactant with low HLB) should increase, therefore span 80 helps to load naproxen into the solid lipid.…”

Section: Effect Of Hlb On Nanoparticles Characterizationmentioning

confidence: 99%

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

(2016) The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and Surfaces B: Biointerfaces, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/67745/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical Abstract Highlights  Naproxen solid lipid nanoparticles (Nap-SLN) can successfully be prepared by ultrasonication  Properties of these nanoparticles can be optimized by lipid concentrations  HLB of the surfactants played a crucial effect on properties of solid lipid nanoparticles  Nap-SLN increased the drug concentration in skin layer rather than systemic absorption Accepted Manuscript AbstractThe aim of the current investigation was to produce naproxen solid lipid nanoparticles (Nap-SLNs) by the ultrasonication method to improve its skin permeation and also to investigate the influence of Hydrophilic-lipophilic balance (HLB) changes on nanoparticles properties. The properties of obtained SLNs loaded with naproxen were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). FT-IR was also used to investigate any interaction between naproxen and the excipients used at the molecular level during the preparation of the SLNs. The performance of the formulations was investigated in terms of skin permeation and also the retention of the drug by the skin. It was found that generally, with increasing the lipid concentration, the average particle size and polydispersity index (PDI) ...

show abstract

Section: Effect Of Hlb On Nanoparticles Characterizationmentioning

confidence: 99%

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

show abstract

“…Normally, MEs are thermodynamically stable; however, their microstructure is continuously changing in the bicontinuous region. 47 Stability is tested according to International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines, 48 which propose to store MEs in different temperature conditions (4°C, 25°C, and 37°C and 75% -5% Relative humidity [RH]) and time frame. As follows, MEs are inspected for any physicochemical differentiation, including phase separation, drug entrapment, precipitation, and particle size changes.…”

Section: Stability-stabilization Of Mesmentioning

confidence: 99%

“…As follows, MEs are inspected for any physicochemical differentiation, including phase separation, drug entrapment, precipitation, and particle size changes. 14,31,47,49 Figure 3 shows representative illustration for possible instabilities in ocular MEs.…”

Section: Stability-stabilization Of Mesmentioning

confidence: 99%

Novel Ocular Drug Delivery Systems: An Update on Microemulsions

Okur

Çağlar

Sıafaka

2020

Journal of Ocular Pharmacology and Therapeutics

View full text Add to dashboard Cite

Sufficient ophthalmic drug delivery is still challenging for pharmaceutical technologists, despite various scientific efforts. Several ocular drug carriers have been designed to enhance bioavailability by prolonging the drug retention time. One of the current encouraging approaches is the utilization of colloidal carriers with the characteristic submicron-nanometer size. Microemulsions (MEs) are such colloid systems that present sizes between 5 and 200 nm with significant thermodynamic stability and low surface tension. In addition, MEs as topical ocular carriers can lead to great ocular drug adsorption due to their enhanced retention time. Furthermore, considering that MEs are stable for long time and various temperatures, their ocular application is of great interest. The aim of this study is to cover basic physicochemical principals of ocular MEs such as their possible size, stability, and therapeutic efficacy against various eye disorders. Thus, a comprehensive review for ocular drug delivery systems in the form of MEs that show promising characteristics as their stability and therapeutic efficiency is performed.

show abstract

“…In the next step, the clear supernatants were filtered through a polytetrafluoroethylene membrane filter (φ = 0.45 μm), and the filtrates were analyzed using UV spectrophotometry at 220 nm. [9] Pseudoternary phase diagram construction…”

Section: Hq Solubilitymentioning

confidence: 99%

Untitled

Salimi¹

2017

AJP

View full text Add to dashboard Cite

Introduction: Hydroquinone (HQ), a famous anti-hyperpigmentation agent, suffers from several weaknesses such as instability due to rapid oxidation and insufficient skin penetration because of the hydrophilic structure. The aim of this research was to formulate, characterize and evaluation of in vitro skin permeability of HQ-loaded microemulsion (ME). Methods: HQ MEs were prepared by pseudoternary phase diagram method, the appropriate ratios of oil, s/c mixture, and water were chosen, and full factorial design was used with three variables at two levels for preparing eight formulations. The prepared MEs were evaluated regarding their droplet size, viscosity, pH, differential scanning calorimetry, stability, in vitro drug release, and in vitro skin permeability. Results and Discussion:The results showed that the mean droplet size range of ME samples was in the range of 7.05-79.56 nm and pH was 5.3-5.7, respectively. Viscosity range of MEs was 109-195 cps. Drug release profile showed that 90.51% of the drug released (ME-HQ-8) in the 24 h of the experiment. The kinetics of drug release from all selected MEs were approximately described by Higuchi model and showed prolonged release when compared to HQ solution. All ME formulations with different compositions and properties significantly increased flux and permeability coefficient from rat skin. J ss and Papp parameters in ME-HQ-2 formulation were 0.404 mg/cm 2 h, 0.02 cm/h, and 4 times higher than those of control, respectively. The selective MEs have 99.9% HQ amount after 6 months storage. They have visually cleared and no any color changes, thus HQ MEs can could been protect drug for a long time without antioxidant. Conclusion: The present research established that the amount of components of water, oil, and S + C in ME formulation plays an important role in the physicochemical properties and permeability parameters. This study showed that any change in content and composition of MEs could be changed physicochemical properties and permeability parameters during drug permeation from ME samples. The studied MEs increased permeation rate and permeability coefficient through rat skin. Our results were showed that ME formulation could not be increase diffusivity of HQ in stratum corneum.

show abstract

Preparation and Microstructural Characterization of Griseofulvin Microemulsions Using Different Experimental Methods: SAXS and DSC

Cited by 26 publications

References 33 publications

The design of naproxen solid lipid nanoparticles to target skin layers

The design of naproxen solid lipid nanoparticles to target skin layers

Novel Ocular Drug Delivery Systems: An Update on Microemulsions

Untitled

Contact Info

Product

Resources

About