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Salimi, Anayatollah

doi:10.22377/ajp.v11i04.1714

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…The permeability coefficient and flux from the rat skin increased significantly in all ME formulations with different features and compositions. In addition, several studies have confirmed the advantages of ME vehicles as promoters of dermal delivery (23,25), which can increase skin permeation by changing drug diffusion or partitioning coefficient (22).…”

Section: Me-k-6mentioning

confidence: 96%

“…According to previous studies, the S/C content in ME vehicles majorly influences the skin permeation of hydroquinone (23). Glycols (PEG400) can improve skin permeation through different mechanisms, including lipid and protein extraction, swelling of the stratum corneum, enhancing drug partitioning into the skin, and improving drug solubility in the formulation (22).…”

Section: Me-k-6mentioning

confidence: 99%

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Transdermal Delivery of Ketorolac Tromethamine Using Microemulsion Vehicles

Salimi

Jafarinezhad

Kalantari

2018

Jundishapur J Nat Pharm Prod

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Background: Ketorolac tromethamine (KT) is described as a nonsteroidal anti-inflammatory drug (NSAID). Among various NSAIDs, ketorolac tromethamine is commonly used for postoperative and emergency relief of pain. Objectives: The goal of this study was to describe and assess the in vitro skin permeability of KT microemulsions (MEs). Methods: The KT ME formulations were prepared using pseudoternary phase diagrams. Appropriate ratios of oil, S/C mixture, and water were selected, and eight formulations were prepared based on a full factorial design consisting of three variables at two levels. The droplet size, differential scanning calorimetry, pH, stability, viscosity, drug release, and skin permeability were examined in the prepared MEs. Results: The droplet size of ME samples ranged from 28.36 to 81.4 nm, and pH was within the range of 5.1 -5.7. In addition, the viscosity of MEs was 38 -135 cps. Considering the drug release profile, 88.04% of the drug (ME-K-1) was released within 24 hours. All ME formulations drastically increased the permeability coefficient and flux in the rat skin. The Jss and Papp parameters were 0.144 mg/cm 2 .h and 0.0057 cm 2 /h in the ME-K-8 formulation, respectively (i.e., 8.42 and 8.41 times higher than the control, respectively). Based on the findings, they were visually cleared, and no phase separation was detected. Conclusions: According to the findings, the oil, S/C mixture, and water contents in ME formulations affect physicochemical characteristics and permeation parameters. The selected MEs increased the rate of permeation and permeability coefficient through rat skin. Ideally, MEs should transfer the drug through the skin while maintaining its size and release it into deep layers of the skin. ME formulations may be proper carriers for transdermal ketorolac delivery, although further research is necessary to validate their therapeutic application.

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Section: Me-k-6mentioning

confidence: 96%

Section: Me-k-6mentioning

confidence: 99%

Transdermal Delivery of Ketorolac Tromethamine Using Microemulsion Vehicles

Salimi

Jafarinezhad

Kalantari

2018

Jundishapur J Nat Pharm Prod

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Intralesional microemulsions for effective dermal delivery of chondroitinase: formulation, characterisation and evaluation

Anil¹,

Krishnamoorthy²

2020

actapharm

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Chondroitinase ABC (chondroitinase, cABC, ChABC or CHASE) is an enzyme with systematic name chondroitin ABC lyase that specifically acts as chondroitin depolymerizer and also effective on other proteoglycans viz. dermatan sulfate, keratan sulfate and hyaluronate in lowering their levels in irregular extracellular matrix (ECM) formation during cartilage repair process in burns and accident, without disturbing other ECM components. Proteoglycans are the molecules with strong negative charge that attract positive ions ABSTRACTThe rationale behind the microemulsion (ME) formulation was to achieve the efficacy of intralesional delivery and permeability of chondroitinase (CHASE) along with enhanced stability over conventional delivery mode and thus patient compliance. The formulation proceeded with the pseudo-ternary phase diagrams construction to identify microemulsions regions and to establish unique ratio of oil surfactants and aqueous phase. The components used for microemulsion formulation were oleic acid as oil phase, Tween 80 and propylene glycol as surfactantcosurfactant mixture and phosphate buffer pH 7.4 as aqueous phase. The concentration of CHASE in microemulsions was 2.96 U/mL which was stabilised with 1M trehalose solution (w/w). The physicochemical properties of microemulsion were determined. The localization of CHASE within the dermal membrane was determined by in vitro permeability study using excised porcine ear skin. The permeation and the penetration properties of CHASE loaded microemulsion were compared with stabilised aqueous solution of CHASE for varied duration.

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Development and Ex-Vivo Skin Permeation of Sildenafil Citrate Microemulsion System for Transdermal Delivery

Jamali,

Moghimipour,

Nikpour

et al. 2024

Iran J Pharm Res

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Background: This study aimed to develop a microemulsion (ME)-based skin delivery platform containing sildenafil citrate (SC)-ME and evaluate its in vitro skin permeability. Methods: Accurate MEs were prepared using pseudo-ternary phase diagrams and a full factorial design with three variables at two levels. After the design phase, suitable ratios of oil, water, and a mixture of surfactant (S) and cosurfactant (CS) were selected to prepare various SC-ME formulations. These SC-MEs were analyzed for stability, droplet size, in vitro SC release, skin permeability, and viscosity properties. Results: The droplet size of the ME samples ranged from 6.24 to 32.65 nm, with viscosities between 114 to 239 cps. Release profiles indicated that 26 to 60% of SC was released from the different SC-MEs within 24 hours. All ME formulations significantly enhanced the permeability coefficient (P) through rat skin. Specifically, the flux (Jss) in SC-ME7 increased by approximately 117 times (Jss = 0.0235 mg/cm2.h) compared to the control sample (0.0002 mg/cm2.h). Conclusions: The study concluded that the proportions of the water or oil phase and the S/CS mixture in the MEs significantly influenced the physicochemical characteristics and permeation parameters. The selected MEs improved both the permeability coefficient and the rate of permeation through rat skin. The enhanced drug delivery through and into deep skin layers is a key attribute of an ideal dermal ME. These findings suggest that MEs could serve as effective transdermal delivery systems for SC and similar drugs. However, in vivo assays and clinical research are needed to confirm the therapeutic efficacy of MEs.

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Cited by 3 publications

References 21 publications

Transdermal Delivery of Ketorolac Tromethamine Using Microemulsion Vehicles

Transdermal Delivery of Ketorolac Tromethamine Using Microemulsion Vehicles

Intralesional microemulsions for effective dermal delivery of chondroitinase: formulation, characterisation and evaluation

Development and Ex-Vivo Skin Permeation of Sildenafil Citrate Microemulsion System for Transdermal Delivery

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