The design of naproxen solid lipid nanoparticles to target skin layers

Abstract

(2016) The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and Surfaces B: Biointerfaces, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/67745/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical Abstract Highlights  Naproxen solid lipid nanoparticles (Nap-SLN) can successfully be prepared by ultrasonication  Properties of these nanoparticles can be optimized by lipid concentrations  HLB of the surfactants played a crucial effect on properties of solid lipid nanoparticles  Nap-SLN increased the drug concentration in skin layer rather than systemic absorption Accepted Manuscript AbstractThe aim of the current investigation was to produce naproxen solid lipid nanoparticles (Nap-SLNs) by the ultrasonication method to improve its skin permeation and also to investigate the influence of Hydrophilic-lipophilic balance (HLB) changes on nanoparticles properties. The properties of obtained SLNs loaded with naproxen were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). FT-IR was also used to investigate any interaction between naproxen and the excipients used at the molecular level during the preparation of the SLNs. The performance of the formulations was investigated in terms of skin permeation and also the retention of the drug by the skin. It was found that generally, with increasing the lipid concentration, the average particle size and polydispersity index (PDI) ...

Nanostructured lipid carriers incorporating prickly pear seed oil for the encapsulation of vitamin A

“…One is the gradual drug expulsion as a result of polymorphic transitioning of the lipid from an α to a more stable βsubcell form . The other is related to the synthesis process, where the highly viscous lipid melt diffuses at a slower rate into the aqueous medium, expelling any drug during the crystallization process …”

“…An empty pan was used as a reference. The temperature rate increase was 10°C/min with a temperature range of 0‐200°C, heated under N 2 gas, as adopted from Akbari et al in their characterization of SLNs …”

“…29,37 The other is related to the synthesis process, where the highly viscous lipid melt diffuses at a slower rate into F I G U R E 2 Polymorphs of fatty acid chains F I G U R E 3 EE% of RP in different NLC (F1-4) and SLN formulations measured freshly after formulation the aqueous medium, expelling any drug during the crystallization process. 20,38 The NLCs showing the highest EE% were F2 and F4. These two formulations incorporated higher amounts of lipid oil.…”

Untitled

“…Many factors influence the properties of the nanospheres such as the nature of used materials, the quantity of drug in the dispersed phase, the concentration of surfactant and the operating conditions (agitation, temperature, pressure) 9,14 . In our study, the only variable factor is the quantity of each drug in the dispersed phase which affects the nanospheres properties.…”

“…Advances in nanotechnology have reduced these side effects by the development of new polymeric nanospheres as drug carriers systems. Nanospheres polymeric coating is important in hindering any link of these drugs to the stomach membrane and maintaining a low and constant level of drug in the blood 9,10 .…”