Preparation and in-vitro evaluation of poly[N-vinyl-2-pyrrolidone-polyethylene glycol diacrylate]-chitosan interpolymeric pH-responsive hydrogels for oral drug delivery

Effect of chitosan coating on the swelling and controlled release of a poorly water-soluble drug from an amphiphilic and pH-sensitive hydrogel

“…Preparation of these media was described in a previous study [27]. Accurately weighed amounts of beads (ranging from 0.1 to 0.2 g) were immersed in 40 mL of desired solution and, at fixed time intervals, the beads were separated from the medium through filtration.…”

Radiation synthesis of poly[(dimethylaminoethyl methacrylate)-co-(ethyleneglycol dimethacrylate)] hydrogels and its application as a carrier for anticancer delivery

“…The drug concentration onto the hydrogels disk was measured and it is used as 0.5 mg/ml. All compositions present an initial release effect may be attributed to the diffusion of the drug caused by rapid gel swelling and also the release of drug adsorbed towards the surface of the gel matrix (Shanta and Harding, 2000). As DMAEMA content increase in the copolymer, the release rate and total released drug increases.…”

Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation

“…Further cationic polyelectrolyte nature of chitosan could provide a strong electrostatic interaction with mucosal surface. [5] The rank order of mucoadhesion for formulations was to be FC1 > FC2 > FC3 > FC4.…”

“…[5,6] A rat stomach mucosa was tied on the glass slide using a thread. About 50 hydrogel pieces were spread on to wet rinsed tissue specimen and prepared slide was hung on to one of the grooves of a USP tablet disintegration apparatus.…”