Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation

Kumar, Gupta Anish; Siddiqui, Abdul Wadood; Maurya, Sandip; Ramchand, Dhakar

doi:10.4103/0973-8398.76738

Cited by 14 publications

(6 citation statements)

References 11 publications

(13 reference statements)

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“…They observed that these covalently cross-linked hydrogels were pH sensitive and showed maximum swelling and drug release at low pH in the stomach environment owing to protonation of an amino group achieving the targeted sustained release. The purpose of introducing acrylic acid as graft is to control the swelling (to avoid burst release) and to achieve sustained release of the antibiotic [ 125 ].…”

Section: Applications Of Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

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Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pK a and pK b values on the ionization, consequent swelling, and targeted drug release are also highlighted.

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Section: Applications Of Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

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“…The mucoadhesive property of a material is generally carried out by two methods: wash-off method and tensile method [187] . The wash-off method involves adhesion of the samples over the excised mucosal lining (attached over a glass slide).…”

Section: Mucoadhesivitymentioning

confidence: 99%

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

Pal

Singh

Anis

et al. 2013

Polymer-Plastics Technology and Engineering

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Hydrogels have evolved over the last decade as materials of choice in varied biomedical applications. This is associated with the inherent biocompatible nature of the hydrogels. The modulation of the properties of the hydrogels is easily possible due to the availability of polymers of varied chemistry and physical properties. This review discusses the pharmaceutical aspects of the controlled release of bioactive agents from hydrogel-based formulations.

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“…Many examples of drug delivery applications using acrylic acid copolymerized with other monomers in natural polymers have been published recently. Gupta et al prepared pH-sensitive hydrogels for the stomach-targeted drug delivery of clarithromycin [ 26 ]. Acrylic acid was used to graft chitosan by free radical polymerization, blended with poly(vinyl pyrrolidone), and crosslinked with glutaraldehyde and N , N -methylenebisacrylamide.…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

et al. 2020

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The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications.

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Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: Preparation and evaluation

Cited by 14 publications

References 11 publications

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

Hydrogel-Based Controlled Release Formulations: Designing Considerations, Characterization Techniques and Applications

pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

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