Radiation synthesis of poly[(dimethylaminoethyl methacrylate)-co-(ethyleneglycol dimethacrylate)] hydrogels and its application as a carrier for anticancer delivery

Mazied, Nabila A.; Ismail, Sahar A.; Taleb, Manal F. Abou

doi:10.1016/j.radphyschem.2009.06.016

Cited by 19 publications

(8 citation statements)

References 21 publications

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“…The gamma-radiation-induced copolymerisation was also assessed by Taleb et al [76] and Mazied et al [77] in their research for applications of the controlled release of chlortetracycline HCl and flutamide, respectively. Mazied et al synthesised hydrogels based on DMAEMA and various ethylene glycol dimethacrylate ratios to demonstrate diffusioncontrolled flutamide administration.…”

Section: Applications In Drug Delivery Systemsmentioning

confidence: 99%

Glassy Polymers—Diffusion, Sorption, Ageing and Applications

et al. 2021

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For the past few decades, researchers have been intrigued by glassy polymers, which have applications ranging from gas separations to corrosion protection to drug delivery systems. The techniques employed to examine the sorption and diffusion of small molecules in glassy polymers are the subject of this review. Diffusion models in glassy polymers are regulated by Fickian and non-Fickian diffusion, with non-Fickian diffusion being more prevalent. The characteristics of glassy polymers are determined by sorption isotherms, and different models have been proposed in the literature to explain sorption in glassy polymers over the last few years. This review also includes the applications of glassy polymers. Despite having many applications, current researchers still have difficulty in implementing coating challenges due to issues such as physical ageing, brittleness, etc., which are briefly discussed in the review.

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Section: Applications In Drug Delivery Systemsmentioning

confidence: 99%

Glassy Polymers—Diffusion, Sorption, Ageing and Applications

et al. 2021

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“…Their potential to deliver the drug to a specific, targeted place has been recognized as one of the properties worth of worldwide research. [1,2] Materials that have shown great potential in this field are external stimuli hydrogels (pH-sensitive, temperature sensitive, sensitive to ionic strength changes, etc). Due to their ability to respond to the changes in the external medium by swelling/contracting and releasing their loadings in the process, they are also widely used in enzymes immobilization, cosmetics, tissue engineering, and so on.…”

Section: Introductionmentioning

confidence: 99%

Modification of hydrophilic polymer network to design a carrier for a poorly water‐soluble substance

Markovič

Panic

Šešlija

et al. 2020

Polymer Engineering & Sci

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pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly watersoluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.

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“…As a typical class of soft and smart materials, stimuli‐responsive hydrogels are able to change their volume in response to small alterations of external physicochemical factors such as pH, temperature, ionic strength, chemical matters, light, electric and magnetic fields . Tertiary amino groups carrying (meth)acrylates have received increasing attention because of their wide applications in biological and therapeutic demands, biosensors, membranes, drug delivery systems, isolation of biomolecules, and smart switch . In this respect, the hydrogels based on poly( N,N ‐dimethylaminoethyl methacrylate) (PDMAEMA) exhibit dual pH‐ and temperature sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Physicomechanical and Swelling Properties of Weakly Basic Copolymer Hydrogels Based on (Meth)acrylate Polycations as New Smart Materials

Celik

Orakdöğen

2015

Macro Chemistry & Physics

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Tayyibe Celik , Nermin Orakdogen* 2-Hydroxyethyl methacrylate (HEMA) is incorporated to N,N -dimethylaminoethyl methacrylate (DMAEMA) fabricating a series of stimuli-responsive copolymer hydrogels by free radical copolymerization. The increasing comonomer content via adding more HEMA results in a higher network density and, therefore, a lower equilibrium swelling ratio. The uniaxial compressive testing results showed that increasing HEMA in the feed improved the mechanical strength of P(DMAEMA-co-HEMA) hydrogels. As HEMA increased, the elastic modulus as well as the effective crosslinked chain density increased. The work strives to provide method to tune mechanical and physical properties for weakly basic copolymer hydrogels based on (meth)acrylate polycations, which is hopefully to guide the design of hydrogels with desirable properties.

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Radiation synthesis of poly[(dimethylaminoethyl methacrylate)-co-(ethyleneglycol dimethacrylate)] hydrogels and its application as a carrier for anticancer delivery

Cited by 19 publications

References 21 publications

Glassy Polymers—Diffusion, Sorption, Ageing and Applications

Glassy Polymers—Diffusion, Sorption, Ageing and Applications

Modification of hydrophilic polymer network to design a carrier for a poorly water‐soluble substance

Correlation Between Physicomechanical and Swelling Properties of Weakly Basic Copolymer Hydrogels Based on (Meth)acrylate Polycations as New Smart Materials

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