Effect of chitosan coating on the swelling and controlled release of a poorly water-soluble drug from an amphiphilic and pH-sensitive hydrogel

Colinet, Isabelle; Dulong, Virginie; Mocanu, Georgeta; Picton, Luc; Cerf, Didier Le

doi:10.1016/j.ijbiomac.2010.05.011

Cited by 37 publications

(25 citation statements)

References 29 publications

(39 reference statements)

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“…In this way, the reduced swelling at pH 4 could be explained by a reduced charge of the hydrogel by the formation of COOH groups. Also, the formation of hydrogen bonds among the NHCO and COOH groups of PU/PDEA gave a more compact network structure, which restricted the movement and relaxation of the chains within the hydrogel and reduced the swelling capacity. Also, the increasing ionic strength (from 0.116 to 0.172) when we moved from pH 5 to pH 4 resulted in a smaller swelling effect as a consequence of the screening of electrostatic repulsions between the protonated amino groups.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and swelling behavior of pH‐responsive polyurethane/poly[2‐(diethylamino)ethyl methacrylate] hybrid materials

Pardini

Amalvy

2013

J of Applied Polymer Sci

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Polyurethane (PU)/poly[2‐(diethylamino)ethyl methacrylate] hybrids, having a chemical bond between the PU and acrylic moieties and with different compositions, were prepared by the dispersion polymerization of 2‐(diethylamino)ethyl methacrylate (DEA) in the presence of preformed PU chains with polymerizable terminal vinyl groups. The PU dispersion was synthesized according to a prepolymer mixing process by the polyaddition of isophorone diisocyanate, poly(propylene glycol), 2‐hydroxyethyl methacrylate, and dimethylol propionic acid (DMPA). Then, it was dispersed in water by the prior neutralization of the carboxylic acid groups of DMPA with triethylamine, chain‐extended with ethylenediamine. The effect of the DEA content on the swelling properties (water uptake and dynamic swelling degree) at different pHs and at 37°C was determined. The samples were also characterized by Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. The experimental results indicate a higher water uptake when the DEA content was increased on the hybrid materials and a significant change in the kinetics of swelling at pH 4 compared to those at pH 7. The water content of the hydrogels depended on the DEA content, and it was inversely proportional to the pH value. The pure PU film did not show important changes over the pH range examined in this study. The synthesized hybrids were useful as drug‐delivery, pH‐sensitive matrices. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39799.

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Section: Resultsmentioning

confidence: 99%

Synthesis and swelling behavior of pH‐responsive polyurethane/poly[2‐(diethylamino)ethyl methacrylate] hybrid materials

Pardini

Amalvy

2013

J of Applied Polymer Sci

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“…In previous work, we have shown that these copolymers crosslinked by Ca 2+ are able to entrap a model drug such as theophylline and to release this drug via control of pH 21, 33. All these results bring important information for drug release with enzymatic control.…”

Section: Resultsmentioning

confidence: 85%

Alginate grafted with poly(ε‐caprolactone): effect of enzymatic degradation on physicochemical properties

Benykhlef

Dulong

Bengharez³

et al. 2012

Polymer International

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The paper discusses the enzymatic behaviour of a series of copolymers composed of alginate grafted with poly(ε-caprolactone) (PCL) of various lengths and degrees of substitution. The study is focused on viscosity measurements and pyrene probe fluorescence with or without two enzymes: alginate lyase, which breaks the alginate backbone; and esterase, which breaks PCL pendent groups. Alginate lyase is inactive at pH = 3.8 and degrades quickly all copolymers at pH = 6.3. The degradation is not complete and is slowed down by the presence of PCL. Esterase degrades only copolymers with long pendent PCL groups. It has no effect on copolymers when PCL has a length of 530 g mol −1 . These systems are good candidates for controlled release of drugs using an enzymatic method.

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“…DMSA chitosan beads showed to be good adsorbent because their swelling percentage is low. The pH of the solution, ionic strength and material of functionalization are swelling factors known to affect the efficiency of the adsorbents [80][81][82][83]. Figure 1 shows the SEM micrographs at 1500x dimensions of PCF (Fig.…”

Section: Adsorbent Characterization Solubility and Swelling Testmentioning

confidence: 99%

Adsorption of arsenic(V) oxyanion from aqueous solutions by using protonated chitosan flakes

Padilla-Rodríguez

Hernández-Viezcas

Peralta-Videa

et al. 2015

Separation Science and Technology

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Arsenate (As(V)) oxyanion removal was achieved utilizing diverse chitosancontaining adsorbents, such as chitosan beads, protonated chitosan flakes, chitosan powder and chitosan functionalized with meso-2,3-dimercapto succinic acid (DMSA), and glutaraldehyde (GLA). Protonated Chitosan Flakes (PCF) showed to be the more effective adsorbent for the removal of As(V) oxyanion from aqueous solutions, removing 97% at the initial concentration of 0.500 mg/L. As(V) adsorption was favored by Langmuir model, with a maximum adsorption capacity (Q 0 ) of 5.43 mg/g. The results showed that the PCF is an excellent non-toxic and inexpensive adsorbent for As(V) oxyanion removal in level traces from aqueous solution.

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Effect of chitosan coating on the swelling and controlled release of a poorly water-soluble drug from an amphiphilic and pH-sensitive hydrogel

Cited by 37 publications

References 29 publications

Synthesis and swelling behavior of pH‐responsive polyurethane/poly[2‐(diethylamino)ethyl methacrylate] hybrid materials

Synthesis and swelling behavior of pH‐responsive polyurethane/poly[2‐(diethylamino)ethyl methacrylate] hybrid materials

Alginate grafted with poly(ε‐caprolactone): effect of enzymatic degradation on physicochemical properties

Adsorption of arsenic(V) oxyanion from aqueous solutions by using protonated chitosan flakes

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