Preparation and in vitro evaluation of topical gel of 5-fluorouracil

Sadeq, Zainab Ahmed; Mohammed, Malek M.

doi:10.51847/ycpsbay4rg

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Spreadability Test1

Centrifugation1

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2022

2023

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Cited by 3 publications

(2 citation statements)

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“…Another glass plate of the same size was used above the glass plate containing the gel. 1 kg scale weight was put for five min on the plate upper side, the diameters of the spreading circle were calculated in cm and were considered as a comparative spreadability value (the spread circle diameter-the initial diameter) [13].…”

Section: Spreadability Testmentioning

confidence: 99%

Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol) ‎

Sadeq¹,

Sabri²,

Al-Kinani³

2022

J Adv Pharm Educ Res

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Section: Spreadability Testmentioning

confidence: 99%

Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol) ‎

Sadeq¹,

Sabri²,

Al-Kinani³

2022

J Adv Pharm Educ Res

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“…The objective of centrifugation was to assess NE's physical stability. For 60 minutes, centrifugation was performed at 3,000 rpm.NE was then tested for transparency, phase segregation, and turbidity [35].…”

Section: Centrifugationmentioning

confidence: 99%

Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV

Rodriques¹,

Prajapati²

2022

Pharmacophore

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The purpose of this research was to develop and evaluate the Nanoemulsion of Dolutegravir sodium. Nanoemulsion was made by the high-shear homogenization method. Materials and method: Oleic acid was used as the oil phase, Tween 80, and Acconon MC8-2 EP/NF (Smix; 1:1) were utilized as surfactant and co-surfactant respectively while distilled water was employed as an aqueous phase. The formulations were evaluated based on globule size, zeta potential, pH, viscosity, percentage transmittance, centrifugation, dye test, dilutability test, and Fourier transform spectroscopy. Furthermore, in vitro drug release studies and stability studies were also conducted. NE1 has shown the least particle size of 96.71 nm, viscosity of 86.4 cp, and maximum drug release of 97.55 % CDR in 45 hrs compared with pure drug (32.98% CDR in 45 hrs). The stability study confirmed no changes in formulations at 1 month at 40 0 ± 2 0 C and 75% ± 5%. The findings suggest that nanoemulsions might be an effective vehicle for the oral administration of Dolutegravir sodium for the treatment of HIV.

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Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability

Parihar,

Prajapati

2023

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Preparation and in vitro evaluation of topical gel of 5-fluorouracil

Cited by 3 publications

References 14 publications

Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol) ‎

Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol) ‎

Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV

Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability

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Preparation and in vitro evaluation of topical gel of 5-fluorouracil

Cited by 3 publications

References 14 publications

Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol) ‎

Natural polymer Effect on gelation and rheology of ketotifen-loaded pH-sensitive in situ ocular gel (Carbapol) ‎

Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV

Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor &amp; Its Optimisation for Solubility and Stability

Contact Info

Product

Resources

About

Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability