The purpose of this research was to develop and evaluate the Nanoemulsion of Dolutegravir sodium. Nanoemulsion was made by the high-shear homogenization method. Materials and method: Oleic acid was used as the oil phase, Tween 80, and Acconon MC8-2 EP/NF (Smix; 1:1) were utilized as surfactant and co-surfactant respectively while distilled water was employed as an aqueous phase. The formulations were evaluated based on globule size, zeta potential, pH, viscosity, percentage transmittance, centrifugation, dye test, dilutability test, and Fourier transform spectroscopy. Furthermore, in vitro drug release studies and stability studies were also conducted. NE1 has shown the least particle size of 96.71 nm, viscosity of 86.4 cp, and maximum drug release of 97.55 % CDR in 45 hrs compared with pure drug (32.98% CDR in 45 hrs). The stability study confirmed no changes in formulations at 1 month at 40 0 ± 2 0 C and 75% ± 5%. The findings suggest that nanoemulsions might be an effective vehicle for the oral administration of Dolutegravir sodium for the treatment of HIV.
Multi-Unit Particulates (MUPs) with matrix pellets are used to develop controlled release products of various active pharmaceutical ingredients. They may allow improvement in solubility and thereby bioavailability of poorly soluble drugs. Omeprazole magnesium is a derivative of benzimidazole which belongs to the group of proton pump inhibitors that exhibits degradation in gastric acid with short biological life and variability in bioavailability. The drug degradation problem was overcome by the coating of pellets with enteric coating agents which disperse in the gastrointestinal tract more homogenously than single units with a rapid transit time. Pellets were compressed to reduce the tampering risk and transportation difficulty through the esophagus. The coating was done with the bottom spray technique. A batch of 5% concentration of binder optimized for a tablet affects the disintegration of the tablet. A cushioning agent was employed to optimize the acid resistance with a concentration of 12% and the release profile was depicted in pH 6.8 phosphate buffer followed by 0.1N HCl for 2 hours. The optimized batch was evaluated for acid resistance, similarity factor, SEM, dissolution, and stability studies which exhibited maximum resistance in gastric pH with abrupt release in duodenal pH because of the multi-particulate approach.
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