Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application

Abstract

Preparation of novel antibacterial and cytocompatible polyurethane membranes as occlusive dressing, which can provide moist and sterile environment over mild exudative wounds is considered in this work. In this regard, an epoxy-terminated polyurethane (EPU) prepolymer based on castor oil and glycidyltriethylammonium chloride (GTEAC) as a reactive bactericidal agent were synthesized. Polyurethane membranes were prepared through cocuring of EPU and different content of GTEAC with 1,4-butane diamine. The physical and mechanical properties, as well as cytocompatibility and antibacterial performance of prepared membranes were studied. Depending on their chemical formulations, the equilibrium water absorption and water vapor transmission rate values of the membranes were in ranges of 3-85% and 53-154g m(-2) day(-1), respectively. Therefore, these transparent membranes can maintain for a long period the moist environment over the wounds with low exudates. Detailed cytotoxicity analysis of samples against mouse L929 fibroblast and MCA-3D keratinocyte cells showed good level of cytocompatibility of membranes after purification via extraction of residual unreacted GTEAC moieties. The antibacterial activity of the membranes against Escherichia coli and Staphylococcus aureus bacteria was also studied. The membrane containing 50% GTEAC exhibited an effective antibacterial activity, while showed acceptable cytocompatibility and therefore, can be applied as an antibacterial occlusive wound dressing.

Thermoresponsive antimicrobial wound dressings via simultaneous thiol-ene polymerization and in situ generation of silver nanoparticles

“…As well, maintaining flexibility and strength 25 during healing period is a crucial property for ideal dressing membranes. 4 To find insight regarding these important issues, tensile properties (tensile strength, modulus, and elongation at beak) of dressings were evaluated from their stress-strain curves recorded on both dry and fully hydrated samples (Fig.9a,b and 30 Table 3). Fig.…”

“…Meanwhile, non-adherence to wound bed and prevention from bacterial/fungal infection of 45 damaged tissues are two key features of versatile modern wound dressings. 4 To prepare wound dressings having the most of aforementioned features, selection of materials used for the preparation of dressings and mode of their fabrication have prime importance. 50 Polyurethane framework was selected in the present study as the basic ingredient of target dressings.…”

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

“…Castor oil polymer induces bone formation with high matrix metalloproteinase-2 expression (Saran et al 2014). It has antiinflammatory (Vieira et al 2000) wound healing (Yari et al 2014) and laxative (Apu et al 2013) efficacies.…”

Assessments of antibacterial and physico-mechanical properties for dental materials with chemically anchored quaternary ammonium moieties: Thiol–ene–methacrylate vs. conventional methacrylate system

“…It was reported that high concentration of positively charged groups in polymers resulted in cytotoxic effect [53][54][55]. However, it is also well recognized that low concentration of charged QAS incorporated in polymers can be helpful for improving the material biocompatibility and rendered them to be safer for clinical applications [56,57,34,58].…”