Assessments of antibacterial and physico-mechanical properties for dental materials with chemically anchored quaternary ammonium moieties: Thiol–ene–methacrylate vs. conventional methacrylate system

Burujeny, Saeed Beigi; Atai, Mohammad; Yeganeh, Hamid

doi:10.1016/j.dental.2014.12.014

Cited by 28 publications

(17 citation statements)

References 56 publications

(89 reference statements)

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“…These stresses and resulting strains may contribute to crack propagation in the filling material, leakage along the tooth-filling interface, bacterial invasion and secondary caries [321,322]. Burujeny and colleagues fabricated thiol-ene-methacrylate containing quaternary amine moieties with reduced polymerization shrinkage stress and strain and improved antibacterial effectiveness [247]. Reduction in polymerization shrinkage has been attributed to the nature of thiol-ene polymerization; delayed gelation produces more homogeneous structure with narrow glass transition temperature ranges and reduced brittleness in comparison with classic methacrylate resin systems [323,324].…”

Section: Dental Materialsmentioning

confidence: 99%

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Jiao

Niu

et al. 2017

Progress in Polymer Science

444

292

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a b s t r a c tMicrobial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.Published by Elsevier B.V.

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Section: Dental Materialsmentioning

confidence: 99%

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Jiao

Niu

et al. 2017

Progress in Polymer Science

444

292

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“…It is claimed that the great advantage of this approach is that the bioactive agent is not released from the matrix, which could contribute to the maintenance of the composites’ properties 8 . However, previous reports have shown that depending on the functionality and the concentration in which they are immobilized into the organic matrix, MQAMs can also reduce the mechanical properties 19 , and increase the water sorption of the composites 4 . Different bacteriostatic and bactericide chemicals, e.g., chlorhexidine, Ag salts and particles, oxides, and others, have also been tested to confer antibacterial activity to resin composites 7 , 25 .…”

Section: Introductionmentioning

confidence: 96%

Model resin composites incorporating ZnO-NP: activity against S. mutans and physicochemical properties characterization

et al. 2018

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Although resin composites are widely used in the clinical practice, the development of recurrent caries at composite-tooth interface still remains as one of the principal shortcomings to be overcome in this field.ObjectivesTo evaluate the activity against S. mutans biofilm of model resin composites incorporating different concentrations of ZnO-nanoparticles (ZnO-NP) and characterize their physicochemical properties.Materials and MethodsDifferent concentrations of ZnO-NP (wt.%): E1=0, E2=0.5, E3=1, E4=2, E5=5 and E6=10 were incorporated into a model resin composite consisting of Bis-GMA-TEGDMA and barium borosilicate particles. The activity against S. mutans biofilm was evaluated by metabolic activity and lactic acid production. The following physicochemical properties were characterized: degree of conversion (DC%), flexural strength (FS), elastic modulus (EM), hardness (KHN), water sorption (Wsp), water solubility (Wsl) and translucency (TP).ResultsE3, E4, E5 and E6 decreased the biofilm metabolic activity and E5 and E6 decreased the lactic acid production (p<0.05). E6 presented the lowest DC% (p<0.05). No significant difference in FS and EM was found for all resin composites (p>0.05). E5 and E6 presented the lowest values of KHN (p<0.05). E6 presented a higher Wsp than E1 (p<0.05) and the highest Wsl (p<0.05). The translucency significantly decreased as the ZnO- NP concentration increased (p<0.05).ConclusionsThe incorporation of 2 – 5 wt.% of ZnO-NP could endow antibacterial activity to resin composites, without jeopardizing their physicochemical properties.

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“…The adhesive exerted stable and long-lasting antibacterial effects because this monomer was immobilized in the resin with limited release of bacterial agent. Burujeny et al [ 83 ] evaluated the antibacterial activity of QAMs against S. aureus and E. coli to judge the release behavior of antibacterial agent in resin composite. It was indicated that no inhibition zone was detected around the samples, and the nonreleasing behavior of active ingredient was confirmed.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

“…They concluded that the inclusion of antimicrobial component quaternary ammonium species did not adversely affect the cytotoxicity of the dentine adhesive. Burujeny et al [ 83 ] found that the copolymerization of quaternary ammonium salt-containing monomers (QASM) incorporating thiolene-rich resin improved the biocompatibility of resin, which provided significant improvement in the biocompatibility of dental materials. Li et al [ 53 ] incorporated monomers of DMAEDM, DMADDM, and Bis-GMA into dental resin composites, and measured their cytotoxicity using a methyl thiazolyltetrazolium assay and live/dead viability assay.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Application of Antimicrobial Polymers in the Development of Dental Resin Composite

et al. 2020

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Dental resin composites have been widely used in a variety of direct and indirect dental restorations due to their aesthetic properties compared to amalgams and similar metals. Despite the fact that dental resin composites can contribute similar mechanical properties, they are more likely to have microbial accumulations leading to secondary caries. Therefore, the effective and long-lasting antimicrobial properties of dental resin composites are of great significance to their clinical applications. The approaches of ascribing antimicrobial properties to the resin composites may be divided into two types: The filler-type and the resin-type. In this review, the resin-type approaches were highlighted. Focusing on the antimicrobial polymers used in dental resin composites, their chemical structures, mechanical properties, antimicrobial effectiveness, releasing profile, and biocompatibility were included, and challenges, as well as future perspectives, were also discussed.

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Assessments of antibacterial and physico-mechanical properties for dental materials with chemically anchored quaternary ammonium moieties: Thiol–ene–methacrylate vs. conventional methacrylate system

Cited by 28 publications

References 56 publications

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Model resin composites incorporating ZnO-NP: activity against S. mutans and physicochemical properties characterization

Application of Antimicrobial Polymers in the Development of Dental Resin Composite

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