Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system

Meng, Zhaoxu; Xu, Xiaoxue; Zheng, Wei; Zhou, Huimin; Li, L.; Zheng, Yufeng; Lou, Xia

doi:10.1016/j.colsurfb.2010.12.022

Cited by 200 publications

(109 citation statements)

References 40 publications

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“…[130] Electrospinning is the most used process to produce PLGA nanofibers, where their physical-chemical properties can be controlled by changing several factors, such as the polymer and/or surfactant concentrations, voltage, viscosity and distance of the tip to the collector. [131] For instance, a composite nanofiber composed by PLGA and hydroxyapatite (HAp) was developed by electrospinning, for recombinant human bone morphogenetic protein-2 (rhBMP-2) delivery. [132] Authors demonstrated that rhBMP-2 was successfully loaded into the composite nanofibers, being released in a controlled manner (2-8 weeks) without loss of its integrity.…”

Section: Poly(lactic-co-glycolic) Acid Nanofibersmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

188

122

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Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

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Section: Poly(lactic-co-glycolic) Acid Nanofibersmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

188

122

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“…Samples were then weighed in the wet condition. 14 The swelling ratio for each sample was calculated according to the following equation:…”

Section: Swelling Indexmentioning

confidence: 99%

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

141

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Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%±1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%±2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%±2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

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“…For lidocaine, drug release rate lasted two weeks. Meng et al [74] worked on Fenbufen (drug) loaded PLGA/gelatin nanofibers, and found that an increase in the content of natural polymer gelatin caused an increase in the release rates of Fenbufen. Nanofibers used as a drug delivery carrier need to accomplish two steps; one is to load the drug cargo, and the other is the controlled release of the drugs.…”

Section: Polymer-based Nanofibers For Drug Deliverymentioning

confidence: 99%

“…It is difficult to get a uniform matrix and requires tedious and elaborate mixing. Meng et al [74] prepared PLGA/gelatin nanofibers integrated with Fenbufen (FBF) drug using a dissolution method. Prior to electrospinning, the composite polymer-drug solution was mixed for 12 h at room temperature.…”

Section: Dissolution/co-electrospinningmentioning

confidence: 99%

Multifunctional Nanofibers towards Active Biomedical Therapeutics

et al. 2015

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One-dimensional (1-D) nanostructures have attracted enormous research interest due to their unique physicochemical properties and wide application potential. These 1-D nanofibers are being increasingly applied to biomedical fields owing to their high surface area-to-volume ratio, high porosity, and the ease of tuning their structures, functionalities, and properties. Many biomedical nanofiber reviews have focused on tissue engineering and drug delivery applications but have very rarely discussed their use as wound dressings. However, nanofibers have enormous potential as wound dressings and other clinical applications that could have wide impacts on the treatment of wounds. Herein, the authors review the main fabrication methods of nanofibers as well as requirements, strategies, and recent applications of nanofibers, and provide perspectives of the challenges and opportunities that face multifunctional nanofibers for active therapeutic applications.

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Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system

Cited by 200 publications

References 40 publications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Multifunctional Nanofibers towards Active Biomedical Therapeutics

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