Multifunctional Nanofibers towards Active Biomedical Therapeutics

Abstract

One-dimensional (1-D) nanostructures have attracted enormous research interest due to their unique physicochemical properties and wide application potential. These 1-D nanofibers are being increasingly applied to biomedical fields owing to their high surface area-to-volume ratio, high porosity, and the ease of tuning their structures, functionalities, and properties. Many biomedical nanofiber reviews have focused on tissue engineering and drug delivery applications but have very rarely discussed their use as wound dressings. However, nanofibers have enormous potential as wound dressings and other clinical applications that could have wide impacts on the treatment of wounds. Herein, the authors review the main fabrication methods of nanofibers as well as requirements, strategies, and recent applications of nanofibers, and provide perspectives of the challenges and opportunities that face multifunctional nanofibers for active therapeutic applications.

Carbon nanotubes, graphene, and their derivatives for heavy metal removal

“…Besides them, there are many other carbon nanomaterials that are used as nanoadsorbents, such as carbon nanofabrics, nanofibers, nanocables, and nanofloral clusters. These carbon nanoadsorbents often exhibit some distinctive characteristics due to their different architectures, which may bring about outstanding adsorption performance, economical costs, and easy recovery [89][90][91][92].…”

A chitin nanofibril-based non-woven tissue as medical dressing: the role of bionanotechnology

“…These polysaccharide polymers play major roles in maintaining body contours by providing mechanical cushion and protection in recovering epithelium and soft tissue for their regeneration [31,32], making them safe for the human body and the environment.…”

Tolnaftate-Loaded PolyacrylateElectrospun Nanofibers for an Impressive Regimen on Dermatophytosis

“…Recently, much research has been focused on fabricating three-dimensional nano fibers for applications in tissue engineering, catalysis, biosensors, skin regeneration, and wound healing by virtue of their extensive surface-to-volume ratio, peculiar morphology, sufficient mechanical strength, and plentiful porosity [8,9]. It is emphasized that the high surface area of nanofibers expedite proper gaseous exchange, charter fluid accumulation, or retention, of wound fluid, maintain moisture balance, and preserve aseptic conditions [10], which are eminently fascinating properties in the mitigation of infectious wound healing. Inherent nano scaled interconnected voids/pores within these nano fibers also restrict further penetration of pathogen at the application site, and provide desirable cell interactions to make them competent for designing regenerative medicine [11,12].…”