Preparation and characterization of 45S5 bioactive glass‐based scaffolds loaded with PHBV microspheres with daidzein release function

Abstract

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microsphere loaded 45S5 bioactive glass (BG) based scaffolds with drug releasing capability have been developed. PHBV microspheres with a mean particle size 4 ± 2 μm loaded with daidzein were obtained by oil-in-water single emulsion solvent evaporation method and applied to the surface of BG scaffolds by dip coating technique. The morphology, in vitro bioactivity in simulated body fluid (SBF), mechanical properties and drug release kinetics of microsphere loaded scaffolds were studied. The microspheres were shown to be homogeneously dispersed on the scaffold surfaces. It was confirmed that hydroxyapatite crystals homogeneously grew not only on the surface of the scaffold but also on the surface of the microspheres within 3 days of immersion in SBF. The daidzein release from the microsphere loaded scaffolds lasted almost 1 month and was determined to be diffusion controlled. The microsphere loaded BG scaffolds with daidzein releasing capability obtained in this study are a candidate for bone tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1765-1774, 2017.

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

“…No significant difference between composite microspheres and blank PHBV microspheres (not containing MBGN) was found. In addition, the size was found to be similar to previous reports on PHA based microspheres fabricated by using similar emulsion techniques [ 13 , 22 , 27 , 28 ]. On the other hand, the size of MBGN ( Figure 1 ) was 177 ± 13 nm, also similar to values previously reported in literature [ 6 , 29 , 30 ].…”

“…Then, a suitable approach to damping these possible effects is the combination of MBGN, and BGs, in general, with other biomaterials [ 7 , 8 , 9 , 10 ]. Specifically, composite structures such as films and coatings for 3D scaffolds have been developed in the last few years [ 10 , 13 , 14 , 15 ].…”

PHBV/bioglass composite scaffolds with co-cultures of endothelial cells and bone marrow stromal cells improve vascularization and osteogenesis for bone tissue engineering

“…3,6,30,31 Composite scaffolds fabricated from polymers and bioceramics can take advantages of polymer and bioceramics, such as biodegradability, biocompatibility and elasticity of polymer as well as bioactivity of bioceramics, which can make up the disadvantages of pure polymer or bioceramics, such as lack of bioactivity, acidic biodegradable products of polymer and brittleness of bioceramics. 3,27,32,33 In addition, the physicochemical and bioactivity properties of composite scaffolds are easily to be controlled through adjusting the component of the scaffolds. In this study, the bioactivity of the PHBV/BG composite scaffolds was adjusted by changing the amount of the BG in the scaffolds.…”

Preparation of CEL2 glass‐ceramic porous scaffolds coated with chitosan microspheres that have a drug delivery function

“…[26][27][28][29][30] Polymer coatings are also known to be drug carriers, providing a viable manner to avoid the risks of side effects associated with oral or parenteral therapies. [33][34][35][36] The aim of the present study was to fabricate CEL2 bioactive glass-ceramic scaffolds coated with chitosan microspheres that have a drug-releasing function for bone regenerative applications. [33][34][35][36] The aim of the present study was to fabricate CEL2 bioactive glass-ceramic scaffolds coated with chitosan microspheres that have a drug-releasing function for bone regenerative applications.…”

“…31,32 Studies have recently been carried out on threedimensional scaffolds with the capacity to release some type of drug through biodegradable microspheres. [33][34][35][36] The aim of the present study was to fabricate CEL2 bioactive glass-ceramic scaffolds coated with chitosan microspheres that have a drug-releasing function for bone regenerative applications.…”