Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Sarika, P.R.; James, Nirmala Rachel

doi:10.1016/j.ijbiomac.2015.02.038

Cited by 41 publications

(26 citation statements)

References 61 publications

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“…Infrared spectrum analysis of the oxidized gums revealed a slight increase in the intensity of the peak in the region of 1725–1735 that identifies aliphatic aldehydes, which were not identifiable in the normal or unoxidized gum arabic. In similar studies by Sarika and James ( 2015 ) and Ali et al ( 2018 ), the aldehyde peak appeared around 1738 and 1728. Apart from this, there was a slight shift in the peak intensity at 1594–1629 in the oxidized GA with increasing the oxidation levels (Fig.…”

Section: Resultssupporting

confidence: 68%

“…Normally, C-O stretching (ether) in the IR spectra appears between 1000 and 1300 cm −1 and the band at 1016 cm −1 is assigned to C-O stretching (C-O-C). The presence of 1594 cm −1 band indicates carboxylate symmetric stretch, whereas the 1412 cm −1 band indicates asymmetric stretch as seen in spectra of gum arabic by Sarika and James (2015) and Ibekwe et al (2017). Infrared spectrum analysis of the oxidized gums revealed a slight increase in the intensity of the peak in the region of 1725-1735 that identifies aliphatic aldehydes, which were not identifiable in the normal or unoxidized gum arabic.…”

Section: Ftir Of Scaffold Formationmentioning

confidence: 92%

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Tissue engineering of collagen scaffolds crosslinked with plant based polysaccharides

et al. 2021

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Ideally, a bioscaffold should mimic the characteristics of an extracellular matrix of a living organ of interest. The present study deals with the formation of composite scaffolds of collagen with gum arabic. Collagen was cross-linked with oxidized gum arabic having aldehyde groups to form a porous block. By changing the oxidation level of gum arabic, incorporation of the polysaccharides into the scaffold could be varied resulting in scaffolds with variable polysaccharide to protein content. A series of scaffolds were made by altering collagen concentration and oxidation level of gum arabic. The scaffolds were tested for their physical properties, stability, biocompatibility and ability to support the cell growth. Results implied that variable polysaccharide incorporation into the scaffolds was possible depending on the oxidation level of gum arabic which could influence the swelling behavior. The scaffolds showed non-toxic behavior towards the mesenchymal stem cells and nucleus pulposa cells using viability assay in culture conditions up to 30 days; the growth of cells was seen at all combinations of gels. Nucleus pulposa cells were able to maintain their phenotype in the GACO gels. The studies show that these scaffolds are potential candidates in applications, such as tissue engineering, and can be designed to match the requirement of different cell/tissues as per their ECM.

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Section: Resultssupporting

confidence: 68%

Section: Ftir Of Scaffold Formationmentioning

confidence: 92%

Tissue engineering of collagen scaffolds crosslinked with plant based polysaccharides

et al. 2021

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“…Two types of nanogels, NDP and NDPC, were synthesized via inverse miniemulsion polymerization in a water-in-oil system, as described previously. 40 NDPMA (80 mg), 10 mg PEGDA, and 10 mg APS were dissolved in 3 mL of deionized (DI) water. The monomer solution was mixed with 20 mL of hexane containing 1 g Span 80 and then sealed in a glass tube.…”

Section: Methodsmentioning

confidence: 99%

Fabrication of Chlorophyll-Incorporated Nanogels for Potential Applications in Photothermal Cancer Therapy

2018

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Nanogels have been widely used in biomedical applications, such as carriers for hyperthermia cancer treatment, drug delivery, and imaging. Owing to the enhanced permeability and retention effect, nanogels have shown a great potential in cancer therapy. In this study, sodium copper chlorophyllin (SCC), a low cytotoxicity and biodegradable photothermal agent, was copolymerized with a nanogel of N-[3-(dimethylamino)propyl]methacrylamide. The nanogels could produce heat under exposure to a green laser with a 532 nm wavelength. The positively charged nature of the nanogels enhanced the endocytosis of the nanogels. The cell mortality was greatly enhanced with the treatment of the SCC-containing nanogels and green light illumination. Our results suggest the potential of SCC-containing nanogels in photothermal cancer therapy.

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“…From the FTIR spectrum, it was terminated that the drug sample was in pure type [55][56][57] The polyose nanogel(CNGs){0.5% polyose solution}, Act loaded polyose nanogel (ActCNGs), AE loaded polyose nanogels (AECNGs) were ready and evaluated. After evaluating this we tend to determine that, FTIR spectra of polyose and CNGs have characteristic peaks at 3500-3400, 1640 (amide I region) and 1070 cm-1(-C-O-stretching.…”

Section: Fourier Transform Infrared Spectrometry (Ft-ir)-mentioning

confidence: 99%

An Updated Review on Nanoparticle Based Approach for Nanogel Drug Delivery System

Chouhan

Rajput

Sahu

et al. 2020

J. Drug Delivery Ther.

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Nanocomposite hydrogels or nanogels (a nanoparticles composed of a hydrogel) are nanomaterial filled, swollen nanosized networks of deliquescent or amphiphilic compound chains. It may be developed by drug - polymer interactions and to create 3D advanced networks. Nanogel may be ready by many strategies just like the particle gelation, Inverse mini emulsion, Dispersion, Chemical cross linking, fabrication of biopolymers and so on. It can be characterized by SEM, DSC, FTIR, Drug content, Particle size, Zeta potential and drug efficiency. Further, it can be evaluated by in vitro drug release and in vivo study in suitable animal modeling. In this review article, we have focused on basic methodology of nanogels, evaluation terms, their application in industry with future prospects for the researchers. Keywords: Nanogel; methods of nanogel preparation; evaluation parameters and their applications.

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Preparation and characterisation of gelatin–gum arabic aldehyde nanogels via inverse miniemulsion technique

Cited by 41 publications

References 61 publications

Tissue engineering of collagen scaffolds crosslinked with plant based polysaccharides

Tissue engineering of collagen scaffolds crosslinked with plant based polysaccharides

Fabrication of Chlorophyll-Incorporated Nanogels for Potential Applications in Photothermal Cancer Therapy

An Updated Review on Nanoparticle Based Approach for Nanogel Drug Delivery System

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