An Updated Review on Nanoparticle Based Approach for Nanogel Drug Delivery System

Chouhan, Chandrika; Rajput, Rudra Pratap Singh; Sahu, Rajani Kanta; Verma, Pratima; Sahu, Suman

doi:10.22270/jddt.v10i5-s.4465

Cited by 8 publications

(4 citation statements)

References 50 publications

(50 reference statements)

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“…After being agitated for six minutes at a rotational speed ranging from (10000-25000) rpm, the suspension is next subjected to sonication for five to ten minutes (Figure 1). 56,57 Application of Nanogel in Drug Delivery and Disease Control El-Sattar et al, developed nanogel delivery system using pH regulation. In this manuscript, monitoring pH has been recognized as a crucial diagnostic component throughout the therapeutic procedure.…”

Section: Modified Diffusion Emulsification Methodsmentioning

confidence: 99%

Nanogel: Types, Methods of Preparation, Limitation, Evaluation and Application – A Systematic Review

Srivastava,

Saha,

Jakhmola

2023

IJDDT

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Nanogels combine the characteristics of nanomaterials with hydrogels. To meet the expanding demands from various areas, a sizable number of nanogels have been designed and manufactured using the emulsion solvent diffusion nano precipitated method, emulsion evaporation of the solvent method, reverse micellar method and modified diffusion emulsification method. Thermosensitive nanogel, pH-sensitive nanogel, ultrasound-sensitive magnetic response, response to multiple stimuli, chain transfer polymerization, photo-induced crosslinking polymerization and modifications for active targeting are the types of nanogels based on response towards stimuli and polysaccharide, chitosan, pullulan, hyaluronic acid, alginate, cyclodextrin, gum acacia, protein are used to prepare nanogel. Nanogels have considerable potential and novelty within the biomedical sector due to their uniformity, adjustable dimensions, little toxicity, resilience in the presence of serum, and capacity for responsive behavior with a comparatively high drug encapsulation capacity. Nanogels have considerable potential in bioactive substance delivery, organ targeting, and chemotherapy. The article highlighted the preparation, types, evaluation and applicability of nanogel as a targeted delivery system.

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Section: Modified Diffusion Emulsification Methodsmentioning

confidence: 99%

Nanogel: Types, Methods of Preparation, Limitation, Evaluation and Application – A Systematic Review

Srivastava,

Saha,

Jakhmola

2023

IJDDT

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“…Chemically cross-linked nanogels consist of polymers formed through covalent chemical interactions ( Chouhan et al, 2020 ). The starting materials are low-molecular-weight monomers, polymer precursors or polymers with specific terminal or pendular reactive groups ( Mauri et al, 2021 ).…”

Section: Nanogels For Cancer Therapymentioning

confidence: 99%

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

et al. 2022

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Cancer is an important cause of morbidity and mortality worldwide, irrespective of the level of human development. Globally, it was estimated that there were 19.3 million new cases of cancer and almost 10 million deaths from cancer in 2020. The importance of prevention, early detection as well as effective cancer therapies cannot be over-emphasized. One of the important strategies in cancer therapy is targeted drug delivery to the specific tumor sites. Nanogels are among the several drug delivery systems (DDS) being explored as potential candidates for targeted drug delivery in cancer therapy. Nanogels, which are new generation, versatile DDS with the possession of dual characteristics of hydrogels and nanoparticles have shown great potential as targeted DDS in cancer therapy. Nanogels are hydrogels with a three-dimensional (3D) tunable porous structure and a particle size in the nanometre range, from 20 to 200 nm. They have been visualized as ideal DDS with enormous drug loading capacity, and high stability. Nanogels can be modified to achieve active targeting and enhance drug accumulation in disease sites. They can be designed to be stimulus-responsive, and react to internal or external stimuli such as pH, temperature, light, redox, thus resulting in the controlled release of loaded drug. This prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. Drugs with severe adverse effects, short circulation half-life, and easy degradability by enzymes, such as anti-cancer drugs, and proteins, are suitable for delivery by chemically cross-linked or physically assembled nanogel systems. This systematic review summarizes the evolution of nanogels for targeted drug delivery for cancer therapy over the last decade. On-going clinical trials and recent applications of nanogels as targeted DDS for cancer therapy will be discussed in detail. The review will be concluded with discussions on safety and regulatory considerations as well as future research prospects of nanogel-targeted drug delivery for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

“…These technologies exhibit considerable significant effect for enhancing drug delivery through the skin and represent attractive avenues for further exploration and development in the field of topical drug delivery. 5 Nano-based systems have the capability to deliver active compounds at minimal concentrations and target them to specific sites of action. This is achieved by utilizing suitable drug carriers, often composed of polymers and other excipients.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanohydrogel in Topical Drug Delivery System

Yuniarsih,

Chaerunisaa,

Elamin

et al. 2024

IJN

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Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on their pertinent contemporary treatments, this review aims to give a complete overview of recent advances in the creation and application of polymer NH in biomedicine. We will explore the key features that have driven advances in nanotechnology and discuss the significance of nanohydrogel-based formulations as vehicles for delivering therapeutic agents topically. The review will also cover the latest findings and references from the literature to support the advancements in nanotechnological technology related to the preparation and application of NH. In addition, we will also discuss the unique properties and potential applications of NH as drug delivery systems (DDS) for skin applications, underscoring their potential for effective topical therapeutic delivery. The challenge lies in efficiently delivering drugs through the skin’s barrier to specific areas with high control. Environmentally sensitive systems, like polymer-based NH, show promise in treating dermatological conditions. Polymers are pivotal in developing these drug delivery systems, with NH offering advantages such as versatile drug loading, controlled release, and enhanced skin penetration.

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An Updated Review on Nanoparticle Based Approach for Nanogel Drug Delivery System

Cited by 8 publications

References 50 publications

Nanogel: Types, Methods of Preparation, Limitation, Evaluation and Application – A Systematic Review

Nanogel: Types, Methods of Preparation, Limitation, Evaluation and Application – A Systematic Review

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

Polymeric Nanohydrogel in Topical Drug Delivery System

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