Prehypertension Is Associated With Insulin Resistance State and Not With an Initial Renal Function ImpairmentA Metabolic Syndrome in Active Subjects in Spain (MESYAS) Registry Substudy

Cordero, Alberto; Laclaustra, Martín; León, Montserrat; Grima, Alberto; Casasnovas, José A.; Luengo, Emilio; Río, Alfonso del; Ferreira, Ignacio; Alegría, Eduardo

doi:10.1016/j.amjhyper.2005.08.018

Cited by 83 publications

(62 citation statements)

References 37 publications

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“…Many papers found the association between insulin resistance and prehypertension 8,38,39 or hypertension 40 . Hyperinsulinemia directly increases sodium re-absorption in renal tubules and may lead to fluid retention 41,42 .…”

Section: Discussionmentioning

confidence: 99%

“…Many cross-sectional studies of different populations demonstrated that prehypertensive individuals had higher total cholesterol, LDL-C, TG and lower HDL-C than normotensive subjects [6][7][8][20][21][22][23][24][25][26][27][28][29][30] . Some prospective studies also showed that dyslipidemia could predict occurrence of incident hypertension by years [31][32][33] .…”

Section: Discussionmentioning

confidence: 99%

“…A study of 1999 to 2000 NHANES data has suggested that 64% of prehypertensive subjects have ≥1 other abnormal CVD risk factors, the percentage increased to 94% in those ≥60 years of age 6 . The risk ratios for obesity, dyslipidemia, metabolic syndrome, and diabetes are all greater in prehypertensive than normotensive subjects 7,8 . The dyslipidemias represent heterogenic metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

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Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Karásek

Vaverková²,

Halenka³

et al. 2013

BIOMED PAP

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Introduction. Like hypertension, prehypertension is associated with cardiovascular disease. Aims. The aim of this study was to evaluate: a) the prevalence of prehypertension/hypertension in individuals with various dyslipidemic phenotypes; b) the relation between blood pressure (BP) and other risk factors for atherosclerosis; c) atherogenic potential of prehypertension by the assessment of intima-media thickness of the arteria carotis communis (IMT). Methods. 667 clinically asymptomatic subjects were divided into four dyslipidemic phenotypes (DLP) according to apolipoprotein B (apoB) and triglycerides (TG): DLP1 (n=198, normo-apoB/normo-TG), DLP2 (n=179, normo-apoB/ hyper-TG), DLP3 (n=87, hyper-apoB/normo-TG), DLP4 (n=203, hyper-apoB/hyper-TG). DLP1 served as a control group. Results. There was significantly higher prevalence of prehypertension and hypertension in subjects with dyslipidemia (DLP2 43.0%, 41.3%; DLP3 42.5%, 29.9%; DLP4 42.4%, 47.8%) than in normolipidemic individuals (DLP1 32.8%, 20.2%). Systolic and diastolic blood pressure (SBP + DBP) correlated with age, total cholesterol, TG, non-HDL-cholesterol, body mass index and waist circumference; SBP additionally with C-peptide, fasting glycemia; DBP additionally with apoB, homeostasis model assessment (HOMA) and plasminogen activator inhibitor-1. The IMT of hypertensive and of prehypertensive subjects was higher than that of subjects with normal BP in all DLPs. Conclusions. The prevalence of prehypertension was higher in all dyslipidemic patients. The common prevalence of prehypertension/hypertension was highest in the hypertriglyceridemic subjects. Prehypertensive and hypertensive patients had higher IMT than normotensive individuals in all DLPs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Karásek

Vaverková²,

Halenka³

et al. 2013

BIOMED PAP

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“…This observation is in line with recent clinical studies in which prehypertension was associated with higher prevalence of metabolic syndrome compared with normotensive status. 25 Psychological stress is another factor potentially involved in the progression of carotid IMT, 26 and hyperactivity to stressful stimuli has been described in WCHs. 27 …”

Section: Discussionmentioning

confidence: 99%

Increase in Carotid Intima-Media Thickness in Grade I Hypertensive Subjects

et al. 2008

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Abstract-We studied 74 never-treated grade I hypertensive subjects aged 18 to 45 years and 20 normotensive control subjects to define the rate of increase in carotid intima-media thickness (IMT) and the potential role played by the various risk factors. IMT was assessed as mean IMT and as maximum IMT in the right and left common carotid artery, carotid bulb, and internal carotid artery at baseline and at the 5-year follow-up. In grade I hypertensive subjects, both mean IMT and mean of maximum IMT were significantly higher compared with baseline values. Compared with normotensive subjects, both mean IMT and maximum IMT increased significantly (at least PϽ0.01) in each carotid artery segment. The increase in cumulative IMT was 3.4-fold for mean IMT and 3.2-fold for mean of maximum IMT. Levels of mean arterial pressure at 24-hour monitoring and total serum cholesterol were factors potentially linked to the increment in mean IMT and mean of maximum IMT. Age was also relevant for the increment in mean of maximum IMT, whereas body mass index played some role in the increment of mean IMT. During the follow-up, mean IMT and mean of maximum IMT increased to a greater degree in white-coat hypertensive subjects (nϭ35) and sustained hypertensive subjects (nϭ39) than in normotensive control subjects. No differences were found between white-coat hypertensive subjects and sustained hypertensive subjects for both mean IMT and maximum IMT. Levels of mean arterial pressure at 24-hour monitoring affected the increment in IMT in both white-coat hypertensive subjects and sustained hypertensive subjects. In conclusion, our findings indicate that carotid IMT is greater and grows faster in white-coat hypertensive subjects than in normotensive subjects without significant differences with sustained hypertensive patients. Key Words: hypertension Ⅲ carotid artery disease Ⅲ ultrasound Ⅲ carotid atherosclerosis E pidemiological studies 1 and intervention trials 2 have established that carotid intima-media thickness (IMT), as measured by ultrasound, is a good marker of atherosclerotic disease. Moreover, ultrasound measurement of carotid IMT has repeatedly been shown to predict the occurrence of both stroke and myocardial infarction in the general population. 3 For these reasons, an increased carotid IMT has been considered by some authors as a marker of subclinical atherosclerosis, 4 although in hypertensive subjects, especially in young subjects, it seems more likely to represent target organ damage. 5 IMT has also been taken as a surrogate end point for clinical events in several intervention trials using antihypertensive medications. 6 Blood pressure (BP) plays a role in the increase in carotid IMT in many 7 but not all studies, 8 and prospective data on the time course of IMT growth and the relative impact of the various risk factors are not defined in untreated hypertensive subjects.In a previous cross-sectional study, we have evaluated a cohort of never-treated, young subjects with grade I hypertension, enrolled at the University of...

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“…Less attention has been paid to the determining factors of prehypertension. Body mass index (BMI or waist girth as determinants of prehypertension was found to be modulated by gender (3), insulin resistance was reported to be associated with prehypertension in a Spanish cohort (4), and ethnic differences among Americans were shown to play a role in the populationattributable risk of prehypertension (5). Adiposity and triglycerides were consistently higher from childhood through adulthood in prehypertensive subjects (6).…”

Section: Introductionmentioning

confidence: 99%

Increased apolipoprotein A-I levels mediate the development of prehypertension among Turks

Onat¹,

Can²,

Örnek³

et al. 2013

Anadolu Kardiyol Derg

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Objective: We aimed to assess whether apolipoprotein (apo) A-I levels that generated type-2 diabetes and coronary disease among Turks contribute to prehypertension and hypertension. Methods: A population-based sample of 2207 adults (mean age 53±11 years) was studied prospectively over a 6.5 years' follow-up. Individuals with hypertension and/or prehypertension were excluded at baseline. Results: At baseline, levels of apoA-I increased in each sex, from the normotensive to prehypertensive and hypertensive group (by mean 7.6 mg/dL, p<0.001) concomitantly with age, waist circumference, fasting triglycerides, apoB, C-reactive protein (CRP) and homeostasis model assessment. In logistic regression models, adjusted for confounders comprising waist circumference or triglycerides, prehypertension was predicted independently by apoA-I at RRs of 1.23 (95%CI 0.97; 1.52)] or 1.32 (95%CI 1.04; 1.74), respectively. Despite showing a positive association, apoA-I did not independently predict in similar models the development of hypertension; the determinants were rather waist circumference, or fasting triglycerides or CRP [RR 1.16 (95%CI 1.05; 1.28)] and, in women, diabetes. In a linear regression analysis for circulating apoA-I including 10 variables, apoB and in men systolic blood pressure were positively associated. Conclusion: In contributing to prehypertension, the pro-inflammatory apoA-I, mediated by apoB, is independent of triglyceridemia. Other inflammatory processes conjointly are likely mechanistically involved in the development of hypertension in a population with prevalent metabolic syndrome. (Anadolu Kardiyol Derg 2013; 13: 306-14) Key words: Apolipoproteins, C-reactive protein, diabetes type-2, obesity, prehypertension, systemic inflammation, regression analysis Original Investigation Özgün Araşt›rma 306ÖZET Amaç: Türk yetişkinlerinde, tip 2 diyabete ve koroner kalp hastalığına sürüklediği gösterilen apolipoprotein (apo) A-I düzeylerinin prehipertansiyon ve hipertansiyonla ilişkili olup olmadığı araştırılmaya değerdir. Yöntemler: Popülasyona dayalı bir örneklem (2207 kişi, ort. yaş 53±11) öne dönük biçimde 6.5 yıl boyunca izlendi. Başlangıçta hipertansiyon ve/ veya prehipertansiyonu olan bireyler dışlandı. Bulgular: Başlangıçtaki apoA-I düzeyleri her iki cinsiyette, yaş, bel çevresi, açlık trigliseridleri, apoB, C-reaktif protein (CRP) ve homeostaz model değerlendirmesi ile birlikte, normotansif gruptan, prehipertensif ve hipertansif gruplara doğru (ort. 7.6 mg/dL, p<0.001) yükseldi. Bel veya trigliseridin katıldığı kovaryatlar için ayarlanan lojistik regresyon modellerinde, prehipertansiyon apoA-I tarafından bağımsız olarak [1.23 (%95 GA 0.97; 1.52)] veya 1.32'lik (%95 GA 1.04; 1.74) nisbi risk oranlarıyla öngörüldü. Pozitif ilişkisine rağmen, apoA-I benzer modellerde hipertansiyon gelişmesini bağımsız olarak öngörmedi; belirleyiciler daha ziyade bel çevresi veya açlık trigliseridi veya CRP [RR 1.16 (%95 GA 1.05; 1.28)] ve kadında, diyabet idi. Serum apoA-I için 10 değişkenden oluşan bir lineer regresyon...

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Prehypertension Is Associated With Insulin Resistance State and Not With an Initial Renal Function ImpairmentA Metabolic Syndrome in Active Subjects in Spain (MESYAS) Registry Substudy

Abstract: Background:The aim of this study was to assess the prevalence of metabolic syndrome (MS) and other surrogate markers of insulin resistance, and whether these markers are better for defining the prehypertensive state than is renal dysfunction.

Cited by 83 publications

References 37 publications

Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Prehypertension in dyslipidemic individuals; relationship to metabolic parameters and intima-media thickness

Increase in Carotid Intima-Media Thickness in Grade I Hypertensive Subjects

Increased apolipoprotein A-I levels mediate the development of prehypertension among Turks

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