Increase in Carotid Intima-Media Thickness in Grade I Hypertensive Subjects

Puato, Massimo; Palatini, Paolo; Zanardo, M.; Dorigatti, Francesca; Tirrito, Carmen; Rattazzi, Marcello; Pauletto, Paolo

doi:10.1161/hypertensionaha.107.106773

Cited by 94 publications

(64 citation statements)

References 31 publications

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“…There was no significant difference between patients with WCHT and those with SHT (P = 0.27). This increase in IMT was associated with triglyceride levels, age and mean arterial pressure at ABPM, as determined by multivariate regression analysis [37] . In a cross-sectional survey that included 2915 Japanese patients aged ≥ 40 years, the carotid IMT was significantly thicker in WCHT patients than in NT patients (0.73 mm vs 0.67 mm, P = 0.001) [38] .…”

Section: Prognosis and Stroke Risk In Patients With White-coat Hypertmentioning

confidence: 82%

“…In contrast, the HARVEST study by Puato et al [37] compared the baseline and follow-up IMT values in 35 WCHT, 20 NT and 39 SHT patients over five years. The baseline (P = 0.004) and follow-up (P < 0.01) IMT values were significantly higher and increased faster in WCHT patients than in NT controls.…”

Section: Prognosis and Stroke Risk In Patients With White-coat Hypertmentioning

confidence: 99%

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Closer look at white-coat hypertension

Sipahioğlu

2014

WJM

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This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension (WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. Studies were included if the WCHT patients were defined according to the 2013 European Society of Hypertension guidelines, i.e., an office blood pressure (BP) of ≥ 140/90 mmHg, a home BP of ≤ 135/85 mmHg, and a mean 24-h ambulatory BP of ≤ 130/80 mmHg. WCHT studies published since 2000 were selected, although a few studies performed before 2000 were used for comparative purposes. True WCHT was defined as normal ABPM and home BP readings, and partial WCHT was defined as an abnormality in one of these two readings. The reported prevalence of WCHT was 15%-45%. The incidence of WCHT tended to be higher in females and in non-smokers. Compared with normotensive (NT) patients, WCHT was associated with a higher left ventricular mass index, higher lipid levels, impaired fasting glucose, and decreased arterial compliance. The circadian rhythm in WCHT patients was more variable than in NT patient's, with a higher pulse pressure and non-dipping characteristics. Compared with sustained hypertension patients, WCHT patients have a better 10-year prognosis; compared with NT patients, WCHT patients have a similar stroke risk, but receive more frequent drug treatment. There are conflicting results regarding WCHT and markers of endothelial damage, oxidative stress and inflammation, and the data imply that WCHT patients may have a worse prognosis. Nitric oxide levels are lower, and oxidative stress parameters are higher in WCHT patients than in NT patients, whereas the antioxidant capacity is lower in WCHT patients than in NT patients. Clinicians should be aware of the risk factors associated with WCHT and patients should be closely monitored especially to identify target organ damage and metabolic syndrome. Key words: White-coat hypertension; Ambulatory blood pressure; Target organ damage; Glucose dysregulation Core tip: There is contradictory information regarding the clinical presentations and prognosis of white-coat hypertension (WCHT). This review aims to summarize recent research and compare it to existing knowledge about WCHT. Published studies on the prevalence of WCHT, the associated target organ damage and cardiovascular markers, and WCHT patient prognosis were reviewed. WCHT may be a marker of future obesity and metabolic syndrome, is related to glucose dysregulation and left ventricular hypertrophy and may progress to sustained hypertension. Clinicians should be aware of the risk factors associated with WCHT, and patients should be closely monitored, especially to identify target organ damage and metabolic syndrome.Sipahioglu NT, Sipahioglu F. Closer look at white-coat hypertension. World

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Section: Prognosis and Stroke Risk In Patients With White-coat Hypertmentioning

confidence: 82%

Section: Prognosis and Stroke Risk In Patients With White-coat Hypertmentioning

confidence: 99%

Closer look at white-coat hypertension

Sipahioğlu

2014

WJM

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“…The hypertensive state is related to progression to more advanced atherosclerosis [30]- [32], calcification of atherosclerosis [32]- [34]. Previous studies using carotid ultrasonography have reported conflicting results with regard to significant differences in IMT of the right and left side: some studies reported a significant difference [16] This study demonstrated the ORs of |ΔSBP| ≥10 mm Hg for the separate and combined effects of obesity and abnormal ABI, regardless of sex and age ( Table 2).…”

Section: Association Of |δSbp| ≥10 MM Hg With Development Of Abnormalmentioning

confidence: 65%

Association between Systolic Blood Pressure Difference ≥10 mm Hg and Ankle-Brachial Index

Maeda¹,

Okumura²,

Hara³

2016

IJCM

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Background: In new outpatients, blood pressure should be measured in both arms. A previous study reported that an inter-arm systolic blood pressure difference (ΔSBP) of ≥10 mm Hg is associated with an increased risk of mortality. Aim: The aim was to identify the associations with absolute values of ΔSBP (|ΔSBP|) ≥10 mm Hg. Subjects and Methods: This study included 2481 patients. Patients with a body mass index ≥25 kg/m 2 were defined as obese. The group of A was defined as following: ankle-brachial index (ABI) was <0.9 or ≥1.3. ΔSBP was expressed as right arm BP minus left arm BP. |ΔSBP| ≥10 mm Hg were analyzed using multivariate logistic analysis. Results: |ΔSBP| ≥10 mm Hg was found in 6.0% of patients and |ΔSBP| < 5 mm Hg in 80.4%. In multivariate analysis, the odds ratios (ORs) of the associations with |ΔSBP| ≥10 mm Hg were significantly associated with abnormal ABI and obesity regardless of sex and age. Moreover, the OR of the combined effects of abnormal ABI and obesity was higher than that of abnormal ABI and obesity alone. Conclusion: |ΔSBP| ≥10 mm Hg was associated with abnormal ABI and obesity. In a primary care setting, blood pressure should be actively measured in both arms. This study suggests that the associations with |ΔSBP| ≥10 mm Hg may be a useful part of screening for abnormal ABI.

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“…Fakat BÖH ile hipertansif hastaların karotis intima media kalınlıkları başlangıçta ve beş yılın sonunda karşılaş-tırıldığında bir fark olmadığı görülmüştür. 14 …”

Section: Beyaz öNlük Hi̇pertansi̇yonu Ve Uç Organ Hasariunclassified

White-Coat Hypertension: Review

Cengiz¹,

Yavuzer²

2016

Turkiye Klinikleri J Intern Med

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13Beyaz Önlük Hipertansiyonu Ö ÖZ ZE ET T Bu çalışmada, beyaz önlük hipertansiyonu (BÖH)'nun klinik ve laboratuvar yönlerini gün-cel bilgilerle açıklamak amaçlanmıştır. BÖH üzerine yapılan son klinik çalışmalar mevcut bilgilerimizle beraber irdelenmiştir. Avrupa Hipertansiyon Derneği tarafından 2013 yılında yayımlanan kılavuza göre; ofis tansiyon ölçümlerinin ≥140/90 mmHg, ev tansiyon ölçümlerinin ≤135/85 mmHg ve 24 saatlik ambulatuar kan basıncı ölçümlerinin ≤130/80 mmHg olması BÖH olarak tanımlan-maktadır. BÖH prevalansının %15-45 oranında olduğu, insidansının kadınlarda ve sigara içmeyen bireylerde daha yüksek olduğu bilinmektedir. BÖH hastalarında dislipidemi, bozulmuş açlık glukozu ve artmış sol ventrikül kitle indeksi normotansiflere göre daha fazla görülmektedir. Tüm klinisyenler, BÖH hastalarını özellikle uç organ hasarı ve metabolik sendrom gelişimleri açısından izlemeli ve BÖH'deki risk faktörleri açısından dikkatli olmalıdır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Beyaz önlük hipertansiyon; hipertansiyon A AB BS S T TR RA AC CT T This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension (WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. WCHT patients were defined according to the 2013 European Society of Hypertension guidelines; an office blood pressure of ≥ 140/90 mmHg, a home blood pressure of ≤ 135/85 mmHg, and a mean 24-h ambulatory blood pressure of ≤130/80 mmHg. The reported prevalence of WCHT was 15%-45% and the incidence of WCHT tended to be higher in females and in non-smokers. Compared with normotensive patients, WCHT was associated with a higher left ventricular mass index, higher lipid levels, impaired fasting glucose, and decreased arterial compliance. Clinicians should be aware of the risk factors associated with WCHT and patients should be closely monitored especially to identify target organ damage and metabolic syndrome.K Ke ey y W Wo or rd ds s: : White-coat hypertension; hypertension T Tu ur r k ki i y ye e K Kl li i n ni ik k l le e r ri i J J I In nt te er rn n M Me ed d 2 20 01 16 6; ;1 1( (1 1) ): :1 13 3--6 6

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Increase in Carotid Intima-Media Thickness in Grade I Hypertensive Subjects

Cited by 94 publications

References 31 publications

Closer look at white-coat hypertension

Closer look at white-coat hypertension

Association between Systolic Blood Pressure Difference ≥10 mm Hg and Ankle-Brachial Index

White-Coat Hypertension: Review

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