Pregnancy and Birth Complications in Psychiatric Patients: A Comparison of Schizophrenic and Personality Disorder Patients With Their Siblings

Woerner, Margaret G.; Pollack, Max; Klein, Donald F.

doi:10.1111/j.1600-0447.1973.tb04460.x

Cited by 54 publications

(16 citation statements)

References 6 publications

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“…In 1967 Stabenau and Pollin (10) published an analysis of birth histories of 100 pairs of monozygotic twins discordant for schizophrenia and reported that significantly more of the schizophrenic (index) twins had been the lighter of the two at birth and had experienced birth complications, particularly asphyxia. However, other investigators subsequently failed to find significant differences in birth weight between schizophrenic subjects and siblings or comparison subjects (11)(12)(13). It is likely that these studies were underpowered to find an effect, as the mean difference in birth weights between groups was actually very similar to that originally reported by Lane and Albee (9).…”

Section: Research On Low Birth Weight (1966-1970)mentioning

confidence: 68%

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Cannon

Jones²,

Murray

2002

AJP

964

664

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Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness. Lack of statistical power to measure small and interactive effects and lack of detailed information about the prenatal period are major problems with current approaches. A combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations.

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Section: Research On Low Birth Weight (1966-1970)mentioning

confidence: 68%

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Cannon

Jones²,

Murray

2002

AJP

964

664

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“…Frequency, but not severity, of complications was raised in adopted schizophrenics (p<O 10) 31 Noni-adopted schizophrenics v normals Severity increased only in non-adopted schizophrenics (p<0O05) Parnas 9 March 1958 (and thus every member of the study cohort) who had been admitted to psychiatric care between 1974 and 1986 could be identified.…”

Section: Midwife Recordsmentioning

confidence: 95%

Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British perinatal mortality survey sample.

Done¹,

Johnstone²,

Frith³

et al. 1991

BMJ

213

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“…There have been reports linking schizophrenia to obstetrical complications (Woerner et al 1973;DeLisi et al 1988;McNiel 1988;Hultman et al 1997;Dalman et al 1999), in utero exposure to alcohol (Lohr and Bracha 1989) and severe malnutrition (Susser and Lin 1992). Although many of these data are controversial (for review, see Weinberger 1995), a number of animal models have been designed to test the plausibility that specific gestational factors play a role in the origin of this disorder.…”

Section: Testing Etiologic Theoriesmentioning

confidence: 99%

To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test

Lipska

Weinberger

2000

Neuropsychopharmacology

585

386

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Animal modeling has been instrumental in dissectingAnimal models are important developments in investigations of the mechanisms underlying a human disease and the design of new treatments. This is true for many diseases, but generally not for mental disorders, whose modeling in experimental animals has often been regarded as a highly controversial or outright heretic idea. An example of a particularly formidable challenge for animal modeling is schizophrenia, a complex disorder of unknown origin, characterized by abnormalities of uniquely human behaviors in the realms of perception, thinking and the experience of emotions, and whose onset is virtually restricted to young adulthood. Schizophrenia is such an inherently human disease that reproducing its most prominent symptoms-hallucinations, delusions and thought disorder-in a rodent or even in a non-human primate seems doomed. However, recent new evidence about the neurobiology of the condition has generated new avenues of animal research. In this perspective article, we highlight recent achievements in the efforts to model the neurobiology of schizophrenia in animals, consider limitations inherent in any heuristic animal model of this and probably other psychiatric disorders, and discuss the usefulness of a new generation of animal models for testing particular hypotheses about etiology and pathophysiology of schizophrenia.

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Pregnancy and Birth Complications in Psychiatric Patients: A Comparison of Schizophrenic and Personality Disorder Patients With Their Siblings

Cited by 54 publications

References 6 publications

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British perinatal mortality survey sample.

To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test

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