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Childhood characteristics, rated “blind” from maternal retrospective reports, were compared for 44 young adult psychiatric inpatients and their “normal” siblings. Patients differed significantly from siblings on several childhood variables and had poorer overall childhood adjustments. Those with the most deviant childhood histories had significantly earlier onsets of psychiatric illness.

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Evidence from a detailed investigation and review of the literature on monozygotic twins discordant for schizophrenia indicates that the schizophrenic index case was lighter in weight at birth than his co-twin (Stabenau and Pollin, 1967). Lane and Albee (1966) reported that schizophrenic singletons were significantly lighter in birth weight than their sibs.

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