Predictors of Bone Mass by Peripheral Quantitative Computed Tomography in Early Adolescent Girls

Moyer‐Mileur, Laurie J.; Xie, Bin; Ball, Shauna D.; Bainbridge, Cynthia N.; Stadler, Diane D.; Jee, Webster S. S.

doi:10.1385/jcd:4:4:313

Cited by 39 publications

(28 citation statements)

References 26 publications

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“…Height is strongly correlated with cortical bone parameters [40] and is a powerful determinant of cortical bone geometry and strength [31,41]. However, height has little or no correlation with radius or tibia BMD [4,6] as these measurements are independent of bone and body size.…”

Section: Discussionmentioning

confidence: 99%

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A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years

et al. 2008

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Section: Discussionmentioning

confidence: 99%

“…study of healthy skeletal development [1][2][3][4][5][6][7][8][9][10] and for the assessment of paediatric disorders associated with skeletal fragility [11][12][13][14][15][16][17][18][19][20][21]. pQCT is designed to measure peripheral skeletal sites such as the radius, tibia and femur.…”

mentioning

confidence: 99%

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years

et al. 2008

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“…Muscle cross-sectional area was used to examine the bone-muscle relationship (25), and the pSSI, a modification of the bone strength index (27), was used to assess bone strength. The pSSI is calculated as follows: (cross-sectional moment of inertia, or bone resistance to bending ϫ bone stiffness calculated by cortical vBMD)/maximum BMD.…”

Section: Methodsmentioning

confidence: 99%

Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritis

Felin¹,

Prahalad²,

Askew³

et al. 2007

Arthritis & Rheumatism

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Objective. To characterize local bone geometry, density, and strength, using peripheral quantitative computed tomography (pQCT), compared with general bone characteristics as measured using dual x-ray absorptiometry (DXA), and to assess their relationship to disease-related factors in children with juvenile rheumatoid arthritis (JRA).Methods. Forty-eight children ages 4-18 years with JRA (17 pauciarticular, 23 polyarticular, 8 systemic) were compared with age-matched healthy controls (n ‫؍‬ 266). Measurements included cortical and trabecular bone geometry, density, and strength at the distal and midshaft tibia determined by pQCT, and whole-body, lumbar spine, and femoral neck measurements by DXA.Results. Methotrexate (MTX) was prescribed to 23 of 48 patients (47.9%) and glucocorticoids and MTX were prescribed to 15 of 48 patients (31.3%), with the greatest use in children with systemic JRA. All JRA patients had decreased tibia trabecular bone density, cortical bone size and strength, and muscle mass. Children with systemic JRA had lower femoral neck densities. Systemic JRA was associated with a shorter, less mineralized skeleton, while a narrower, less mineralized skeleton was observed in polyarticular JRA. The tibia diaphysis was narrower with decreased muscle mass, but normal, size-adjusted bone mineral in all subtypes indicated a localized effect of JRA on bone. Patients exposed to glucocorticoids and MTX or to glucocorticoids or MTX alone had greatly reduced trabecular density, cortical bone geometry properties, and bone mineral content, muscle mass, and bone strength.Conclusion. Children with JRA have decreased skeletal size, muscle mass, trabecular bone density, cortical bone geometry, and strength. Not surprisingly, these bone abnormalities are more pronounced in children with greater disease severity.

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“…An alternative method, peripheral quantitative computed tomography (pQCT), measures appendicular sites such as the radius or tibia, utilizes low local radiation dosage, and is relatively fast and inexpensive. 15 The purpose of this cross-sectional study, therefore, was to assess the relationship of bone characteristics measured by pQCT and DEXA, disease duration, glycemic control, and insulin regime and dosage in adolescents with type 1 DM. We hypothesized that bone characteristics would be significantly different in adolescents with type 1 DM compared with a healthy reference.…”

mentioning

confidence: 99%

Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus

Heap

Murray

Miller

et al. 2004

The Journal of Pediatrics

151

112

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Predictors of Bone Mass by Peripheral Quantitative Computed Tomography in Early Adolescent Girls

Cited by 39 publications

References 26 publications

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years

Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritis

Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus

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