Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus

Heap, Jenny; Murray, Mary; Miller, Scott C.; Jalili, Thunder; Moyer‐Mileur, Laurie J.

doi:10.1016/j.jpeds.2003.10.066

Cited by 149 publications

(140 citation statements)

References 37 publications

(36 reference statements)

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…A negative influence of type 1 diabetes on bone has been observed in a number of case-control studies conducted in adults [2,22] as well as in children and adolescents [1,4,6,[23][24][25], where peripheral and axial DXA and QCT were employed. It has been suggested that observed differences in adults may result from mineralisation disorders, which operate during rapid skeletal development in puberty.…”

Section: Discussionmentioning

confidence: 99%

“…The influence of diabetes on bone status in young people has been described relatively recently [1]. In adults with type 1 diabetes, studies based on measurements at different skeletal sites have shown decreased bone mineral density (BMD) [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…In adults with type 1 diabetes, studies based on measurements at different skeletal sites have shown decreased bone mineral density (BMD) [1,2]. The results and causative factors related to the hypothesised bone mineralisation diminution and bone disturbance in children and adolescents are more equivocal [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…The results and causative factors related to the hypothesised bone mineralisation diminution and bone disturbance in children and adolescents are more equivocal [3][4][5][6][7][8][9]. In adolescents with type 1 diabetes the influence of unsatisfactory metabolic control [1,7,8], disease duration [6][7][8] and high insulin requirement [9] have been postulated. Dual x-ray absorptiometry (DXA) remains a gold standard in bone densitometry.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bone status in adolescents with type 1 diabetes

Chobot¹,

Haffke

Polańska

et al. 2010

Diabetologia

View full text Add to dashboard Cite

Aims The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other diseaserelated and growth variables was analysed. Methods Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA 1c T was higher than 7.0% when compared with those whose HbA 1c T was lower. Conclusions Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bone status in adolescents with type 1 diabetes

Chobot¹,

Haffke

Polańska

et al. 2010

Diabetologia

View full text Add to dashboard Cite

show abstract

“…A history of diabetes, diabetes duration and chronic complications are associated with an increased risk of osteoporotic fracture [1,2], while the fracture site may also be influenced by whether or not the patient has diabetes [3]. The association between low bone mineral density (BMD) and diabetes has most consistently been observed in type 1 patients [4,5], with increased bone mineral loss attributed to early age at diagnosis, long duration, prolonged poor glycaemic control and high insulin doses [6][7][8][9]. In type 2 diabetes, the relationship is less clear, with reports of increased [10], decreased [11] or unchanged [12] bone mass and BMD, probably reflecting the heterogeneity of the disease and/or the different study methodologies used.…”

Section: Introductionmentioning

confidence: 99%

Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis: We assessed the effects of type 1 and type 2 diabetes on bone density and metabolism.Materials and methods: We analysed bone mineral density (BMD) measured at the hip, spine and forearm using dual energy X-ray absorptiometry in 34 patients with type 1 and 194 patients with type 2 diabetes. Patients were from the community-based Fremantle Diabetes Study, and findings for them were compared with those from normal age-and sex-matched control subjects from the local community. Biochemical and hormonal markers of bone metabolism were measured in a subset of 70 patients. Results: After adjusting for age and BMI, there was a lower BMD at total hip (p<0.001) and femoral neck (p=0.012) in type 1 men vs control subjects, but type 1 women and matched controls had similar BMD at each site. There was a higher BMD at total hip (p=0.006), femoral neck (p=0.026) and forearm (p<0.001) in type 2 women vs control subjects, but diabetes status was not associated with BMD in type 2 men after adjustment for age and BMI. Serum oestradiol, BMI, C-terminal telopeptide of collagen type 1 and male sex were consistently and independently associated with BMD at forearm, hip and femoral neck and explained 61, 55 and 50% of the total variance in BMD, respectively, at these sites. Spine BMD was independently associated with BMI and ln(oestradiol). Conclusions/interpretation: Men with type 1 diabetes may be at increased risk of osteoporosis, while type 2 women appear to be protected even after adjusting for BMI. Low serum oestradiol concentrations may predispose to diabetes-associated osteoporosis regardless of sex.

show abstract

The postpartum effect of maternal diabetes on the circulating levels of sirtuins and superoxide dismutase

2018

View full text Add to dashboard Cite

Gestational diabetes mellitus ( GDM ) is a glucose intolerance disorder which occurs during pregnancy as a result of insulin insensitivity; it usually disappears after delivery. However, some women with GDM can develop type 2 diabetes (T2D) after delivery, and the mechanisms by which this occurs remain unknown. This study compared the levels of sirtuins ( NAD ‐dependent deacetylases) and antioxidative enzymes in postpartum women with previous GDM ( pGDM ) or T2D and in postpartum women with a previous healthy pregnancy (controls). Women with pGDM showed upregulated levels of sirtuin 1 ( SIRT 1) mRNA and protein, with reduced expression levels of sirtuin 3 ( SIRT 3 ) and superoxide dismutase 2 ( SOD 2 ), relative to the controls. Women with T2D similarly showed a lower level of SIRT 3 mRNA than the controls. Lipid peroxidation (malondialdehyde) was higher in women with pGDM than in the controls. These data show that in women with pGDM , the reduced level of SIRT 3 may play a role in the reduced SOD 2 level, possibly leading to oxidative stress, which, in turn, upregulates the level of SIRT 1 . These results might confer the risk of future diabetes development in women with pGDM , as a similar reduction in SIRT 3 was found in women with T2D.

show abstract

Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus

Cited by 149 publications

References 37 publications

Bone status in adolescents with type 1 diabetes

Bone status in adolescents with type 1 diabetes

Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

The postpartum effect of maternal diabetes on the circulating levels of sirtuins and superoxide dismutase

Contact Info

Product

Resources

About