Bone status in adolescents with type 1 diabetes

Chobot, Agata; Haffke, Anna; Polańska, Joanna; Halaba, Zenon; Deja, Grażyna; Jarosz-Chobot, Przemysława; Pluskiewicz, Wojciech

doi:10.1007/s00125-010-1782-0

Cited by 15 publications

(23 citation statements)

References 28 publications

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“…Low values for these parameters were reported in T1DM, which appeared to correlate with the duration of diabetes (59,60,61) and the degree of metabolic control (61,62,63).…”

Section: Quantitative and Structural Bases Of Bone Fragilitymentioning

confidence: 91%

“…Quantitative ultrasound (QUS) parameters, including speed of sound (SOS), broadband ultrasound attenuation (BUA) and derived variables like ultrasound BMD or stiffness index of the radius, tibia, calcaneus or phalanges, have been reported in patients with T1DM in a limited number of studies (42,59,60,61,62,63). Low values for these parameters were reported in T1DM, which appeared to correlate with the duration of diabetes (59,60,61) and the degree of metabolic control (61,62,63).…”

Section: Quantitative and Structural Bases Of Bone Fragilitymentioning

confidence: 99%

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MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Hough

Pierroz²,

Cooper

et al. 2016

European Journal of Endocrinology

129

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Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased bone resorption. Insulin/IGF1 deficiency appears to be a major pathogenetic mechanism involved, along with glucose toxicity, marrow adiposity, inflammation, adipokine and other metabolic alterations that may all play a role on altering bone turnover. In turn, increasing physical activity in children with diabetes as well as good glycaemic control appears to provide some improvement of bone parameters, although robust clinical studies are still lacking. In this context, the role of osteoporosis drugs remains unknown.

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“…Low values for these parameters were reported in T1DM, which appeared to correlate with the duration of diabetes (59,60,61) and the degree of metabolic control (61,62,63).…”

Section: Quantitative and Structural Bases Of Bone Fragilitymentioning

confidence: 91%

Section: Quantitative and Structural Bases Of Bone Fragilitymentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Hough

Pierroz²,

Cooper

et al. 2016

European Journal of Endocrinology

129

View full text Add to dashboard Cite

show abstract

“…Moreover, the school in Chocianów participated in European programs on healthy nutrition, which could be another important factor [19]. It is well known that environmental factors, poor nutrition and diseases can worsen bone status [6][7][8]. There were no differences in Ad-SoS between the younger and older group, or scans of the dominant and non-dominant hands.…”

Section: Discussionmentioning

confidence: 99%

“…Various diseases can result in lower bone mass and size [3][4][5][6]. Worsened mechanical properties of bones were found, using ultrasound, in children and adolescents suffering from different diseases such as diabetes mellitus, chronic renal failure or leukemia survivors [7][8][9].The morphological development of the human body, especially the growing of the skeleton, depends on genetic and health factors, nutrition and environment. Most dynamic skeletal gain occurs within 13-16 years in girls, and 16-18 years in boys, respectively.…”

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confidence: 99%

Quantitative Ultrasound at the Hand Phalanges in Adolescent Girls is Related to Their Overall Physical Fitness

et al. 2016

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mal growth hormone and thyroid hormone secretion influence bone mass and mineralization. On the other hand, in the time of puberty, the physical activity of girls typically decreases, which can negatively influence bone mass. Various diseases can result in lower bone mass and size [3][4][5][6]. Worsened mechanical properties of bones were found, using ultrasound, in children and adolescents suffering from different diseases such as diabetes mellitus, chronic renal failure or leukemia survivors [7][8][9].The morphological development of the human body, especially the growing of the skeleton, depends on genetic and health factors, nutrition and environment. Most dynamic skeletal gain occurs within 13-16 years in girls, and 16-18 years in boys, respectively. Bone size and mass are correlated with body size, body mass index (BMI), waist and abdomen circumferences, and depend on physical activity, nutrition and muscle strength [1,2] AbstractBackground. Growing of the skeleton, depends on genetic, health, nutritional and environmental influences. Objectives. The aim of the study was to assess the ultrasound properties of bone measured at hand phalanges in adolescent girls regarding the influence of pubertal status and level of physical fitness. Material and Methods. The study group was 56 adolescent girls aged 12-14 yrs, the controls were 86 girls matched for age, recruited from 1256 subjects undergoing bone measurement for screening purposes. The skeletal status (amplitude-dependent speed of sound -Ad-SoS) was assessed by quantitative ultrasound (QUS) at proximal phalanges using DBM Sonic 1200. Physical fitness was assessed by the Zuchora index and pubertal development by the Tanner scale. Results. The adolescent girls from our study group had greater body weight, height, BMI and Ad-SoS values than the controls. Overall physical fitness was highest in girls with the lowest BMI and lowest in girls with the highest BMI values. The highest results of the Ad-SoS were reported in girls presenting highest level of physical fitness. They were statistically significantly higher than in girls with a minimal level of physical fitness. There was a statistically significant correlation between the overall physical fitness score and Ad-SoS results. No correlations between Ad-SoS and the Tanner scale, particular the elements of physical fitness (speed, jumping ability, flexibility, shoulder muscular strength, abdominal muscle strength) and BMI were shown. Conclusions. The bone properties assessed by QUS at the hand phalanges in adolescent girls aged 12-14 years depend on their overall physical fitness. Pubertal development, body size and particular elements of physical fitness, especially shoulder muscular strength, have limited influence (Adv Clin Exp Med 2016, 25, 2, 279-284).

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“…Delayed puberty, growth hormone deficiency, hypothyroidism and other diseases can result in lower bone mass and size. Decreased mechanical properties of bones assessed by ultrasound have been shown in children and adolescents suffering from different diseases, for example chronic renal failure or leukemia survivors [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Quantitative ultrasound at the hand phalanges in adolescent boys in relation to their pubertal development and physical efficiency

Chwałczyńska¹,

Pluskiewicz²,

Syrycka³

et al. 2013

Endokrynologia Polska

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Introduction: Our aim was to assess the ultrasound properties of bone measured at hand phalanges in 55 adolescent boys aged 13-15 years regarding the influence of pubertal status and level of physical efficiency including muscular strength. Material and methods: They were divided into two age groups: Group I (n = 37, boys aged 159-171 months) and Group II (n = 18, aged 172-184 months). The controls were 94 boys matched for age, recruited from 1,256 subjects undergoing bone measurement for screening purposes. The skeletal status (amplitude-dependent speed of sound -Ad-SoS) was assessed by quantitative ultrasound (QUS) at proximal phalanges with the use of DBM Sonic 1200. Physical efficiency was assessed using Zuchora's test, and pubertal development by Tanner's score. Results: There was no difference in mean Ad-SoS between the entire study group and controls. Ad-SoS values were greater in older than in younger boys, both in right and left hands. There were no differences between left and right hand measurements. There were positive correlations between Ad-SoS and shoulder muscle strength in boys. Negative correlations between Ad-SoS at phalanges of right and left hand and BMI were shown in younger adolescent boys only. Similarly, only in the younger group were positive correlations present between both hands Ad-SoS and overall physical efficiency and age. Ad-SoS correlated positively better with Tanner's scale scoring in the older group. Conclusions: QUS at hand phalanges in adolescent boys aged 13-15 years depends on pubertal development and shoulder muscle strength. The overall physical efficiency has limited influence on bone properties assessed by QUS.

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Bone status in adolescents with type 1 diabetes

Cited by 15 publications

References 28 publications

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus

Quantitative Ultrasound at the Hand Phalanges in Adolescent Girls is Related to Their Overall Physical Fitness

Quantitative ultrasound at the hand phalanges in adolescent boys in relation to their pubertal development and physical efficiency

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